Q9JLI8
PR
Gene name |
Sart3 |
Protein name |
Squamous cell carcinoma antigen recognized by T-cells 3 |
Names |
SART-3, mSART-3, Tumor-rejection antigen SART3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:53890 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JLI8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JLI8-F1 | Predicted | AlphaFoldDB |
54 variants for Q9JLI8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs214822724 | 61 | G>D | No | EVA | |
| rs3388773454 | 212 | E>K | No | EVA | |
| rs3388781616 | 238 | A>V | No | EVA | |
| rs3388752585 | 295 | K>N | No | EVA | |
| rs3388782485 | 321 | E>* | No | EVA | |
| rs214397367 | 324 | I>T | No | EVA | |
| rs3388785834 | 339 | V>M | No | EVA | |
| rs3388776933 | 354 | Y>* | No | EVA | |
| rs3388752558 | 392 | R>* | No | EVA | |
| rs3412115788 | 412 | F>V | No | EVA | |
| rs3388773852 | 425 | Y>* | No | EVA | |
| rs3388776919 | 426 | L>F | No | EVA | |
| rs3388762939 | 440 | S>C | No | EVA | |
| rs3388770686 | 449 | M>L | No | EVA | |
| rs3388762949 | 459 | Q>* | No | EVA | |
| rs3388779787 | 478 | S>T | No | EVA | |
| rs3388773449 | 480 | A>V | No | EVA | |
| rs3388782450 | 482 | V>L | No | EVA | |
| rs3388766516 | 501 | M>K | No | EVA | |
| rs3388779756 | 523 | G>C | No | EVA | |
| rs3388781551 | 534 | R>Q | No | EVA | |
| rs3388787102 | 536 | V>L | No | EVA | |
| rs3388777457 | 571 | E>* | No | EVA | |
| rs3412087316 | 571 | E>V | No | EVA | |
| rs3388762978 | 572 | T>DG* | No | EVA | |
| rs3388785869 | 572 | T>R | No | EVA | |
| rs3388773878 | 573 | R>C | No | EVA | |
| rs3388782455 | 585 | A>T | No | EVA | |
| rs3388785826 | 614 | K>R | No | EVA | |
| rs3388780998 | 624 | R>H | No | EVA | |
| rs253357586 | 626 | E>A | No | EVA | |
| rs223063373 | 656 | E>A | No | EVA | |
| rs3388773486 | 659 | A>V | No | EVA | |
| rs3388785835 | 660 | M>L | No | EVA | |
| rs3388787078 | 668 | G>W | No | EVA | |
| rs3388752541 | 670 | C>Y | No | EVA | |
| rs3396039114 | 712 | P>HRPQRAA* | No | EVA | |
| rs3395675163 | 713 | Y>* | No | EVA | |
| rs3388766491 | 735 | I>N | No | EVA | |
| rs13470008 | 755 | E>A | No | EVA | |
| rs3388782127 | 786 | N>I | No | EVA | |
| rs3388781536 | 793 | R>S | No | EVA | |
| rs3388782439 | 839 | K>N | No | EVA | |
| rs3388773472 | 852 | S>P | No | EVA | |
| rs3388766529 | 860 | K>E | No | EVA | |
| rs3388776942 | 893 | P>L | No | EVA | |
| rs239841693 | 898 | L>V | No | EVA | |
| rs3388781628 | 920 | L>Q | No | EVA | |
| rs3388773828 | 922 | R>H | No | EVA | |
| rs3388777469 | 923 | Q>H | No | EVA | |
| rs3388752508 | 923 | Q>P | No | EVA | |
| rs3388762989 | 925 | A>V | No | EVA | |
| rs3388785859 | 932 | G>S | No | EVA | |
| rs3388781019 | 955 | F>Y | No | EVA |
No associated diseases with Q9JLI8
12 regional properties for Q9JLI8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 704 - 782 | IPR000504-1 |
| domain | RNA recognition motif domain | 801 - 878 | IPR000504-2 |
| repeat | HAT (Half-A-TPR) repeat | 127 - 159 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 165 - 196 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 202 - 238 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 325 - 357 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 360 - 392 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 395 - 431 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 488 - 521 | IPR003107-7 |
| domain | LSM-interacting domain | 944 - 961 | IPR008669 |
| domain | SART3, RNA recognition motif 1 | 705 - 778 | IPR034217 |
| domain | SART3, RNA recognition motif 2 | 799 - 879 | IPR034218 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| ASAP complex | A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1. |
| Cajal body | A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U4/U6 snRNP | A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes. |
| U6atac snRNP | A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| U4 snRNA binding | Binding to a U4 small nuclear RNA (U4 snRNA). |
| U6 snRNA binding | Binding to a U6 small nuclear RNA (U6 snRNA). |
| U6atac snRNA binding | Binding to a U6atac small nuclear RNA (U6atac snRNA). |
| ubiquitin-specific protease binding | Binding to a ubiquitin-specific protease. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| hematopoietic stem cell proliferation | The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. |
| homeostasis of number of cells | Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| positive regulation of histone deubiquitination | Any process that activates or increases the frequency, rate or extent of histone deubiquitination. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| spliceosomal snRNP assembly | The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9W4D2 | Rnp4F | RNA-binding protein 4F | Drosophila melanogaster (Fruit fly) | PR |
| Q15020 | SART3 | Squamous cell carcinoma antigen recognized by T-cells 3 | Homo sapiens (Human) | PR |
| B3DJT0 | sart3 | Squamous cell carcinoma antigen recognized by T-cells 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATTAASSAS | EPEVEPQAGP | EAEGEEDEAK | PAGVQRKVLS | GAVAAEAAEA | KGPGWDLQRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GASGSDGDEE | DAMASSAESS | AGEDEWEYDE | EEEKNQLEIE | RLEEQLSING | YDYNCHVELI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLLRLEGELS | RVRAARQKMS | ELFPLTEELW | LEWLHDEISM | AMDGLDREHV | YELFERAVKD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YICPNIWLEY | GQYSVGGIGQ | KGGLEKVRSV | FERALSSVGL | HMTKGLAIWE | AYREFESAIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EAARLEKVHS | LFRRQLAIPL | YEMEATFAEY | EEWSEEPMPE | SVLQSYQKAL | GQLEKYKPYE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EALLQAEAPR | LAEYQAYIDF | EMKIGDPARI | QLIFERALVE | NCLVPDLWIR | YSQYLDRQLK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VKDLVLSVHS | RAVRNCPWTV | ALWSRYLLAM | ERHGLDHQTI | SATFENALSA | GFIQATDYVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IWQVYLDYLR | RRVDFRQDSS | KELEELRSMF | TRALEYLQQE | VEERFSESGD | PSCLIMQSWA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RVEARLCNNM | QKARELWDSI | MTRGNAKYAN | MWLEYYNLER | AHGDTQHCRK | ALHRAVQCTS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DYPEHVCEVL | LTMERTEGTL | EDWDLAIQKT | ETRLARVNEQ | RMKAAEKEAA | LVQQEEEKAE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QRKKVRAEKK | ALKKKKKTRG | ADKRREDEDE | ENEWGEEEEE | QPSKRRRTEN | SLASGEASAM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KEETELSGKC | LTIDVGPPSK | QKEKAASLKR | DMPKVAHDSS | KDSVTVFVSN | LPYSIEEPEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KLRPLFEVCG | EVVQIRPIFS | NRGDFRGYCY | VEFGEEKSAQ | QALELDRKIV | EGRPMFVSPC |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VDKSKNPDFK | VFRYSTTLEK | HKLFISGLPF | SCTKEELEDI | CKAHGTVKDL | RLVTNRAGKP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KGLAYVEYEN | ESQASQAVMK | MDGMTIRENV | IKVAISNPPQ | RKVPEKPEVR | TAPGAPMLPR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QMYGARGKGR | TQLSLLPRAL | QRQGAAPQAE | NGPAPGPAVA | PSVATEAPKM | SNADFAKLLL |
| RK |