Q9W1J3

PR
Gene name
CG5543
Protein name
Gastrulation defective protein 1 homolog
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG5543
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

507-606 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W1J3

Entry ID Method Resolution Chain Position Source
AF-Q9W1J3-F1 Predicted AlphaFoldDB

No variants for Q9W1J3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W1J3

No associated diseases with Q9W1J3

7 regional properties for Q9W1J3

Type Name Position InterPro Accession
repeat WD40 repeat 171 - 210 IPR001680-1
repeat WD40 repeat 217 - 257 IPR001680-2
repeat WD40 repeat 269 - 312 IPR001680-3
repeat WD40 repeat 316 - 360 IPR001680-4
repeat WD40 repeat 368 - 409 IPR001680-5
repeat WD40 repeat 461 - 500 IPR001680-6
conserved_site WD40 repeat, conserved site 347 - 361 IPR019775

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
regulation of DNA double-strand break processing Any process that modulates the frequency, rate or extent of DNA double-strand break processing.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32LB0 WDR70 WD repeat-containing protein 70 Bos taurus (Bovine) PR
Q9NW82 WDR70 WD repeat-containing protein 70 Homo sapiens (Human) PR
Q3TWF6 Wdr70 WD repeat-containing protein 70 Mus musculus (Mouse) PR
Q5EB92 Wdr70 WD repeat-containing protein 70 Rattus norvegicus (Rat) PR
Q0VA16 wdr70 WD repeat-containing protein 70 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MQRGKISFGK IKLNVNVPPA EPRSNETEAE DAKESTEASG NGGGFKKMDK EQMIRQIEDV
70 80 90 100 110 120
AEDLESQHLK EVMGISGFGR KAAKVFDINE QIEKARVTRP GMDKKREESK PKEDDQKDEE
130 140 150 160 170 180
EEDVIGPLPP AVTTDKEKAT KESSKDEDSD DDDYSSDEDS DDEQSLAKRI PYTHEVQMQH
190 200 210 220 230 240
GSRAVLALAG DPSGARLVSG SIDYDMCFWD FAGMDSSMRS FRQLQPCENH PIRSLQYSVT
250 260 270 280 290 300
GDMILVISGN AQAKVLDRDG FEKLECCKGD QYISDMSRTK GHVAQLTSGC WHPFNREQFL
310 320 330 340 350 360
TAALDGTLRI WQGLKSKEQL QVIKTRAQGG LRTNAASCNF NRDATLIAAG CVDGSIQTWD
370 380 390 400 410 420
TRKMFVNTTH CVRDAHQKGS EITSIVFSYM GQQLATRSND ETMKLWDLRQ FKQPLHTWTN
430 440 450 460 470 480
LFSRYDTTDC CFSPDDRLLV TGESLPKGQA EANLYFYSTK SYEEVQRIPV SNAHVVKTLW
490 500 510 520 530 540
HPKLNQLFVS CGNGTIKCYY DEHRSIRGAK LCVVKTHRKR QPMEMVGVSQ IITPHALPLF
550 560 570 580 590 600
RQEKSRTSRK RMEKARMDPV KSQRPDLPIT SGQGGRVASS GGTLSSYVIR NLGLSKRVDD
610 620 630 640 650
DQDPREAILK YAKDAAENPY WIAPAYKQTQ PKAIFSEKLP ADEPATKKPK TEADK