Q5EB92

PR
Gene name
Wdr70
Protein name
WD repeat-containing protein 70
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:294783
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EB92

Entry ID Method Resolution Chain Position Source
AF-Q5EB92-F1 Predicted AlphaFoldDB

No variants for Q5EB92

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5EB92

No associated diseases with Q5EB92

9 regional properties for Q5EB92

Type Name Position InterPro Accession
repeat WD40 repeat 172 - 211 IPR001680-1
repeat WD40 repeat 218 - 258 IPR001680-2
repeat WD40 repeat 270 - 322 IPR001680-3
repeat WD40 repeat 322 - 361 IPR001680-4
repeat WD40 repeat 365 - 409 IPR001680-5
repeat WD40 repeat 461 - 500 IPR001680-6
repeat G-protein beta WD-40 repeat 198 - 212 IPR020472-1
repeat G-protein beta WD-40 repeat 300 - 314 IPR020472-2
repeat G-protein beta WD-40 repeat 394 - 408 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

1 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.

1 GO annotations of biological process

Name Definition
regulation of DNA double-strand break processing Any process that modulates the frequency, rate or extent of DNA double-strand break processing.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32LB0 WDR70 WD repeat-containing protein 70 Bos taurus (Bovine) PR
Q9W1J3 CG5543 Gastrulation defective protein 1 homolog Drosophila melanogaster (Fruit fly) PR
Q9NW82 WDR70 WD repeat-containing protein 70 Homo sapiens (Human) PR
Q3TWF6 Wdr70 WD repeat-containing protein 70 Mus musculus (Mouse) PR
Q0VA16 wdr70 WD repeat-containing protein 70 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MEHSGPSEVT GADTAGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA VERSRKTLEA
70 80 90 100 110 120
REKEEEMNRE KELRKQLEDI EPTPSSSSAV RERSKSSSRD TSSSDSDHSS GSSDDELIGP
130 140 150 160 170 180
PLPPEMVGGP VNTVDEDILG PLPPPLCEEG EDDDDDDLED EGEEDNPIHR IPDSHEITLK
190 200 210 220 230 240
HGTKTVSALG LDPSGARLVT GGYDYDVKFW DFAGMDASFK AFRSLQPCEC HQIKSLQYSN
250 260 270 280 290 300
TGDMILVVSG SSQAKVIDRD GFEVMECIKG DQYIVDMANT KGHTAMLHTG SWHPKIKGEF
310 320 330 340 350 360
MTCSNDATVR LWEVENPKKQ KSVFKPRTMQ GKKVIPTTCT YSRDGNLVAA ACQNGSIQIW
370 380 390 400 410 420
DRNLTVHPKF HYKQAHAPGT DTSCVAFSYD GNVLASRGGD DTLKLWDVRQ FNKPLFSASD
430 440 450 460 470 480
LPTLFPMTDC CFSPDDKLIV TGTSVQRGCG SGKLVFFERR TFQRVYEIHI TDASVVRCLW
490 500 510 520 530 540
HPKLNQIMVG TGNGLAKVYY DPNKSQRGAK LCVVKTQRKA KQAETLTQDY IITPHALPMF
550 560 570 580 590 600
REPRQRSTRK QLEKDRLDPL KSHKPEPPVA GPGRGGRVGT HGGTLSSYIV KNIALDKTDD
610 620 630 640 650
SNPREAILRH AKAAEDNPYW VSPAYSKTQP KTMFAQVESD DEESKNEPEW KKRKI