Q0VA16

PR
Gene name
wdr70
Protein name
WD repeat-containing protein 70
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:780253
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VA16

Entry ID Method Resolution Chain Position Source
AF-Q0VA16-F1 Predicted AlphaFoldDB

No variants for Q0VA16

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0VA16

No associated diseases with Q0VA16

10 regional properties for Q0VA16

Type Name Position InterPro Accession
repeat WD40 repeat 139 - 178 IPR001680-1
repeat WD40 repeat 185 - 225 IPR001680-2
repeat WD40 repeat 237 - 289 IPR001680-3
repeat WD40 repeat 289 - 328 IPR001680-4
repeat WD40 repeat 333 - 374 IPR001680-5
repeat WD40 repeat 380 - 425 IPR001680-6
repeat WD40 repeat 428 - 467 IPR001680-7
repeat G-protein beta WD-40 repeat 165 - 179 IPR020472-1
repeat G-protein beta WD-40 repeat 267 - 281 IPR020472-2
repeat G-protein beta WD-40 repeat 315 - 329 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
regulation of DNA double-strand break processing Any process that modulates the frequency, rate or extent of DNA double-strand break processing.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32LB0 WDR70 WD repeat-containing protein 70 Bos taurus (Bovine) PR
Q9W1J3 CG5543 Gastrulation defective protein 1 homolog Drosophila melanogaster (Fruit fly) PR
Q9NW82 WDR70 WD repeat-containing protein 70 Homo sapiens (Human) PR
Q3TWF6 Wdr70 WD repeat-containing protein 70 Mus musculus (Mouse) PR
Q5EB92 Wdr70 WD repeat-containing protein 70 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDENEDSSIA ATMGFSGFGK KARTFDLEAM FEQTRRTAVE RSKKTLEARE KEEQISNKSP
70 80 90 100 110 120
VMKDVPSSSR QKNTDTSSSS SGSEDSSDDE LIGPPVPSNL TGDHGDELIG PPLPSGYKDS
130 140 150 160 170 180
DDEDEEQHED DDNPVKGIPD SHEITLQHGT KTVSALGLDP SGARLVTGGF DYDVRFWDFA
190 200 210 220 230 240
GMDASLQAFR SLQPCECHQI KSLQYSNTGD VILVVAGNSQ AKVLDRDGFP VMECVKGDQY
250 260 270 280 290 300
IVDMANTKGH TAMLNGGCWH PKIKEEFMTC SNDGTVRTWD VSNEKKHKGV FKPRSMQGKR
310 320 330 340 350 360
VIPTCCTYSR DGKFIAAGCQ DGSIQIWDRN MSVHTKFHCR QAHTPGTDTS CVTFSYAGNI
370 380 390 400 410 420
LATRGGDDTL KTWDIRKFKN PLNVASGLAN YFPMTDCCFS PDDKLLITGT SVKRGGGDGK
430 440 450 460 470 480
LMFFDVGTFQ KVYEIQVTEA SVVRCLWHPK LNQIMVGTGN GLAKVYYDPN RSQRGAKLCV
490 500 510 520 530 540
VKTQRKARQA ETLTQDYIIT PHALPMFREP RQRSTRKQLE KDRLDPVKSH KPEPPVAGPG
550 560 570 580 590 600
RGGRVGTHGG TLSSFIVKNI ALDKTDDSNP REAILRHAKD AEKNPYWVAP AYSKTQPNTV
610 620
FAEVESDEEE TDNEPEWKKR KI