Q9VKD3
Gene name |
Nfs1 |
Protein name |
Cysteine desulfurase, mitochondrial |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG12264 |
EC number |
2.8.1.7: Sulfurtransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VKD3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VKD3-F1 | Predicted | AlphaFoldDB |
No variants for Q9VKD3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VKD3 | |||||
No associated diseases with Q9VKD3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.8.1.7 | Sulfurtransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| L-cysteine desulfurase complex | A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine desulfurase activity | Catalysis of the reaction: L-cysteine |
| iron-sulfur cluster binding | +Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. |
| metal ion binding | Binding to a metal ion. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| [2Fe-2S] cluster assembly | The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. |
| iron-sulfur cluster assembly | The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. |
| mitochondrial tRNA thio-modification | The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQKVLGRIQA | QVLRSRATNA | LANVVRHEAT | SSRTAAKPAA | TSKEFRERQV | RFNIKNEQTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRPLYLDAQA | TTPMDPRVLD | AMLPYLTNFY | GNPHSRTHAY | GWETESAVEK | AREQVATLIG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADPKEIIFTS | GATESNNIAV | KGVARFYGTK | KRHVITTQTE | HKCVLDSCRA | LENEGFKVTY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPVLANGLID | LQQLEETITS | ETSLVSIMTV | NNEIGVRQPV | DEIGKLCRSR | RVFFHTDAAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVGKVPLDVN | AMNIDLMSIS | GHKIYGPKGV | GALYVRRRPR | VRLEPIQSGG | GQERGLRSGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VPAPLAVGLG | AAAELSLREM | DYDKKWVDFL | SNRLLDRISS | ALPHVIRNGD | AKATYNGCLN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSFAYVEGES | LLMALKDVAL | SSGSACTSAS | LEPSYVLRAI | GTDEDLAHSS | IRFGIGRFTT |
| 430 | 440 | 450 | 460 | ||
| VEEVDYTADK | CIKHVERLRE | MSPLWEMVQE | GIDLKTIQWS | QH |