A2VDS1

PR
Gene name
SCLY
Protein name
Selenocysteine lyase
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:790815
EC number
4.4.1.16: Carbon-sulfur lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-98 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2VDS1

Entry ID Method Resolution Chain Position Source
AF-A2VDS1-F1 Predicted AlphaFoldDB

231 variants for A2VDS1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs473342396 6 A>P No EVA
rs441942475 13 S>R No EVA
rs455581255 15 A>G No EVA
rs475624165 18 S>R No EVA
rs521484299 78 M>V No EVA
rs479828087 95 S>A No EVA
rs479828087 95 S>P No EVA
rs479828087 95 S>T No EVA
rs468887745 97 N>T No EVA
rs437400939 100 I>L No EVA
rs464549080 101 Q>P No EVA
rs452142013 103 V>G No EVA
rs454775544 106 H>N No EVA
rs474889290 106 H>P No EVA
rs443491487 108 H>Y No EVA
rs463552184 109 K>E No EVA
rs459825916 111 H>P No EVA
rs448461030 112 A>G No EVA
rs479897957 112 A>P No EVA
rs462332111 113 A>S No EVA
rs462332111 113 A>T No EVA
rs482330595 114 N>Y No EVA
rs464606354 118 G>A No EVA
rs445717794 119 G>R No EVA
rs465862175 120 H>P No EVA
rs454507721 122 N>H No EVA
rs474551241 122 N>S No EVA
rs474551241 122 N>T No EVA
rs437104174 123 P>R No EVA
rs457198947 124 V>A No EVA
rs457198947 124 V>G No EVA
rs439370204 125 D>E No EVA
rs470812223 125 D>G No EVA
rs473526915 127 A>P No EVA
rs473526915 127 A>S No EVA
rs473526915 127 A>T No EVA
rs442049665 128 L>P No EVA
rs481992169 130 H>N No EVA
rs451117431 130 H>P No EVA
rs458251486 131 I>F No EVA
rs458251486 131 I>L No EVA
rs478480915 131 I>S No EVA
rs478480915 131 I>T No EVA
rs447028416 132 I>L No EVA
rs465871013 132 I>S No EVA
rs465871013 132 I>T No EVA
rs447028416 132 I>V No EVA
rs434477780 133 T>P No EVA
rs448143508 134 C>G No EVA
rs448143508 134 C>R No EVA
rs468185617 134 C>S No EVA
rs436768249 135 T>A No EVA
rs436768249 135 T>P No EVA
rs436768249 135 T>S No EVA
rs433025425 136 V>A No EVA
rs433025425 136 V>E No EVA
rs433025425 136 V>G No EVA
rs470873871 136 V>M No EVA
rs473139827 137 E>* No EVA
rs442126087 137 E>A No EVA
rs455643361 137 E>D No EVA
rs442126087 137 E>G No EVA
rs473139827 137 E>K No EVA
rs473139827 137 E>Q No EVA
rs475635409 138 H>L No EVA
rs475635409 138 H>P No EVA
rs458314742 139 D>A No EVA
rs478548927 139 D>E No EVA
rs444381314 139 D>H No EVA
rs444381314 139 D>N No EVA
rs458314742 139 D>V No EVA
rs444381314 139 D>Y No EVA
rs440644513 140 S>A No EVA
rs440644513 140 S>P No EVA
rs480842473 141 I>F No EVA
rs480842473 141 I>L No EVA
rs468255233 141 I>M No EVA
rs133039007 141 I>T No EVA
rs133913645 142 R>L No EVA
rs133913645 142 R>P No EVA
rs450516373 143 L>V No EVA
rs453099367 147 H>P No EVA
rs466816033 149 R>G No EVA
rs435330602 149 R>K No EVA
rs455706750 153 V>G No EVA
rs385609107 153 V>M No EVA
rs475697501 154 A>P No EVA
rs452084857 156 V>G No EVA
rs1114936973 157 T>A No EVA
rs434688284 160 P>H No EVA
rs474829765 163 K>E No EVA
rs463857780 164 V>G No EVA
rs443430846 164 V>M No EVA
rs439647797 170 A>G No EVA
rs459763716 171 E>G No EVA
rs519866331 173 I>V No EVA
rs448724188 174 L>M No EVA
rs482263363 175 A>S No EVA
rs451070681 177 V>A No EVA
rs799951674 177 V>I No EVA
rs464675255 178 R>C No EVA
rs464675255 178 R>S No EVA
rs445660290 179 P>R No EVA
rs477150483 179 P>S No EVA
rs434345975 181 T>R No EVA
rs468461741 182 C>G No EVA
rs468461741 182 C>R No EVA
rs468461741 182 C>S No EVA
rs437038080 182 C>S No EVA
rs470737775 184 V>G No EVA
rs439703597 185 T>N No EVA
rs453315105 186 I>L No EVA
rs473237210 187 M>I No EVA
rs462326318 189 A>V No EVA
rs482324785 193 T>M No EVA
rs458365331 195 V>D No EVA
rs478423521 196 I>N No EVA
rs465849632 197 M>I No EVA
rs445752865 197 M>K No EVA
rs469449580 199 V>E No EVA
rs438035957 200 P>L No EVA
rs451603963 201 E>G No EVA
rs471770090 204 R>Q No EVA
rs454399764 206 V>D No EVA
rs454399764 206 V>G No EVA
rs445048189 207 R>L No EVA
rs474431534 208 A>D No EVA
rs461883717 210 N>T No EVA
rs475507926 212 Q>H No EVA
rs457677657 214 V>G No EVA
rs440293337 216 G>A No EVA
rs460263343 217 G>V No EVA
rs448993710 218 L>P No EVA
rs483198723 219 P>A No EVA
rs465349936 221 V>A No EVA
rs465349936 221 V>E No EVA
rs465349936 221 V>G No EVA
rs445294876 221 V>L No EVA
rs454463246 223 V>L No EVA
rs468065157 225 T>A No EVA
rs476803307 226 D>A No EVA
rs456683934 226 D>N No EVA
rs444112863 235 R>H No EVA
rs451363919 237 D>Y No EVA
rs465124051 238 V>M No EVA
rs439955887 239 R>G No EVA
rs460325933 243 V>L No EVA
rs480324720 244 D>G No EVA
rs442637318 246 L>M No EVA
rs462742354 246 L>P No EVA
rs482845994 247 T>P No EVA
rs445324549 248 I>L No EVA
rs466566144 292 T>P No EVA
rs458245515 303 E>G No EVA
rs446849735 305 V>G No EVA
rs466900812 311 A>D No EVA
rs435903536 312 Y>D No EVA
rs449589262 312 Y>S No EVA
rs469618521 313 E>K No EVA
rs438107887 314 A>D No EVA
rs470796481 315 H>Y No EVA
rs453158107 321 D>A No EVA
rs473126679 322 Y>S No EVA
rs441529362 326 R>G No EVA
rs461583709 327 L>R No EVA
rs475255556 328 A>G No EVA
rs458881427 329 A>S No EVA
rs479098405 330 E>D No EVA
rs461309841 333 E>G No EVA
rs480193647 334 R>S No EVA
rs134843767 338 N>T No EVA
rs449013806 339 S>R No EVA
rs1117896216 340 Q>E No EVA
rs469068190 343 G>C No EVA
rs437890890 350 T>S No EVA
rs466136155 354 S>Y No EVA
rs445174517 356 R>W No EVA
rs433602555 357 G>R No EVA
rs459248235 362 G>D No EVA
rs448544354 363 R>P No EVA
rs462176332 364 A>P No EVA
rs482519117 365 V>G No EVA
rs451160883 366 L>V No EVA
rs478216215 367 A>G No EVA
rs464849135 367 A>P No EVA
rs467023598 368 Q>P No EVA
rs455869092 369 C>R No EVA
rs437006799 371 T>A No EVA
rs439143781 375 S>G No EVA
rs452792156 376 V>G No EVA
rs472852593 379 A>P No EVA
rs461710198 382 S>P No EVA
rs482446693 383 D>V No EVA
rs1117305746 385 G>W No EVA
rs444609716 386 D>Y No EVA
rs459072222 391 V>G No EVA
rs477775052 392 L>M No EVA
rs446611835 395 C>W No EVA
rs435454793 399 V>G No EVA
rs466660636 399 V>L No EVA
rs449211106 400 D>E No EVA
rs468935956 401 V>G No EVA
rs451265488 405 A>T No EVA
rs471507092 406 I>L No EVA
rs454324359 411 G>D No EVA
rs443084119 412 R>H No EVA
rs463297043 414 S>R No EVA
rs476597785 415 T>N No EVA
rs458839239 418 E>* No EVA
rs478919748 418 E>G No EVA
rs460167213 419 V>A No EVA
rs460167213 419 V>E No EVA
rs460167213 419 V>G No EVA
rs441317356 419 V>L No EVA
rs441317356 419 V>M No EVA
rs480255103 420 D>V No EVA
rs469327364 421 L>H No EVA
rs449064682 421 L>I No EVA
rs482650183 422 V>G No EVA
rs444837107 424 Q>P No EVA
rs465015512 425 D>G No EVA
rs453864128 430 V>G No EVA
rs467954709 431 A>S No EVA
rs436616628 432 R>W No EVA
rs456747544 433 L>R No EVA
rs476950019 434 E>G No EVA
rs452389930 435 G>D No EVA
rs452389930 435 G>V No EVA
rs472447239 436 Q>P No EVA
rs461309538 438 A>E No EVA
rs461309538 438 A>Q No EVA

No associated diseases with A2VDS1

1 regional properties for A2VDS1

Type Name Position InterPro Accession
domain Aminotransferase class V domain 25 - 421 IPR000192

Functions

Description
EC Number 4.4.1.16 Carbon-sulfur lyases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

2 GO annotations of molecular function

Name Definition
selenocysteine lyase activity Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VKD3 Nfs1 Cysteine desulfurase, mitochondrial Drosophila melanogaster (Fruit fly) PR
Q9Y697 NFS1 Cysteine desulfurase, mitochondrial Homo sapiens (Human) PR
Q68FT9 Scly Selenocysteine lyase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEAAGARNRD ARSRAEKSPP ESRKVYMDYN ATTPLEPEVI EAMTEAMREA WGNPSSSYPA
70 80 90 100 110 120
GRKAKEIINT ARENLAKMIG GQPQDVIFTS GGTESNNLVI QSVVKHFHKV HAANGDTGGH
130 140 150 160 170 180
PNPVDGALPH IITCTVEHDS IRLPLEHLRE ERVAEVTFVP VSKVNGQVEA EDILAAVRPA
190 200 210 220 230 240
TCLVTIMLAN NETGVIMPVP EISRRVRALN QQRVAGGLPG VLVHTDAAQA LGKQRVDVRD
250 260 270 280 290 300
LGVDFLTIVG HKFYGPRIGA LYVRGLGEHT PLYPMLFGGG QERNFRPGTE NTPMIAGLGK
310 320 330 340 350 360
AAELVAENGE AYEAHMRGVR DYLEERLAAE FGERIHLNSQ FPGAERLPNT CNFSIRGPQL
370 380 390 400 410 420
QGRAVLAQCR TLLASVGAAC HSDLGDRPSP VLLSCGVPVD VARNAIRLSV GRSSTRAEVD
430
LVVQDLKQAV ARLEGQA