Q68FT9

PR
Gene name
Scly
Protein name
Selenocysteine lyase
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:363285
EC number
4.4.1.16: Carbon-sulfur lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q68FT9

Entry ID Method Resolution Chain Position Source
3A9X X-ray 200 A A/B 1-432 PDB
3A9Y X-ray 185 A A/B 1-432 PDB
3A9Z X-ray 155 A A/B 1-432 PDB
AF-Q68FT9-F1 Predicted AlphaFoldDB

No variants for Q68FT9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q68FT9

No associated diseases with Q68FT9

1 regional properties for Q68FT9

Type Name Position InterPro Accession
domain Aminotransferase class V domain 20 - 416 IPR000192

Functions

Description
EC Number 4.4.1.16 Carbon-sulfur lyases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
catalytic complex A protein complex which is capable of catalytic activity.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

5 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
protein homodimerization activity Binding to an identical protein to form a homodimer.
selenocysteine lyase activity Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
vitamin B6 binding Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate.

5 GO annotations of biological process

Name Definition
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
negative regulation of cellular response to oxidative stress Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
selenium compound metabolic process The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.
selenocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDS1 SCLY Selenocysteine lyase Bos taurus (Bovine) PR
Q9VKD3 Nfs1 Cysteine desulfurase, mitochondrial Drosophila melanogaster (Fruit fly) PR
Q9Y697 NFS1 Cysteine desulfurase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MDVARNGARG SVESPPNRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS SSYVAGRKAK
70 80 90 100 110 120
DIINTARASL AKMIGGKPQD IIFTSGGTES NNLVIHSTVR CFHEQQTLQG RTVDQISPEE
130 140 150 160 170 180
GTRPHFITCT VEHDSIRLPL EHLVEDQVAE VTFVPVSKVN GQVEVEDILA AVRPTTCLVT
190 200 210 220 230 240
IMLANNETGV IMPISEISRR IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF
250 260 270 280 290 300
LTIVGHKFYG PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV
310 320 330 340 350 360
SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI QGSQLRGYMV
370 380 390 400 410 420
LAQCQTLLAS VGASCHSDHE DRPSPVLLSC GIPVDVARNA VRLSVGRSTT RAEVDLIVQD
430
LKQAVNQLEG PV