Q9VKB4

PR
Gene name
CG6712
Protein name
Probable ribosome production factor 1
Names
Ribosome biogenesis protein RPF1
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6712
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-200 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VKB4

Entry ID Method Resolution Chain Position Source
AF-Q9VKB4-F1 Predicted AlphaFoldDB

No variants for Q9VKB4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VKB4

No associated diseases with Q9VKB4

1 regional properties for Q9VKB4

Type Name Position InterPro Accession
domain Brix domain 185 - 369 IPR007109

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA primary transcript binding Binding to an unprocessed ribosomal RNA transcript.

4 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.
maturation of LSU-rRNA Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38805 RPF1 Ribosome production factor 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P54073 F44G4.1 Brix domain-containing protein F44G4.1 Caenorhabditis elegans PR
Q6IQU6 rpf1 Ribosome production factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MIKIKRKTAP PPVEQDSDSD SSFDEEEPQD LEVQEGPVTD SSDEEAASSS KKTAKQGEAS
70 80 90 100 110 120
EDLKEEDDDD DEEENDDDDE EEDDDDDDDK KTRIPVLNPL SWMRNKEQRL ALYKKMKKEK
130 140 150 160 170 180
HKKKMQERRA RRKAGVPANP GHTIESLREK DQTEVANLND SDNEELQKEL QLDDFSSYFE
190 200 210 220 230 240
RSYEPKVLIT FADNPVTKTR KFGLELSRIF PNALVKIRNK SSVKKICKSA EREEFTDVVI
250 260 270 280 290 300
VNEDRRKPNG LLVIHLPNGP TAHFKLSNVK LTSDIKRDHK EITKHRPEVI LNNFTTRLGL
310 320 330 340 350 360
TVGRMLGALF HHDPEFRGRR AVTFHNQRDY IFFRHHRYEF TKEGKRVKLR ELGPRFTLKL
370 380 390
RSLQEGTFDS KTGDYAWIIS NKRHAMESRR RFFL