P38805
Gene name |
RPF1 (YHR088W) |
Protein name |
Ribosome production factor 1 |
Names |
Ribosome biogenesis protein RPF1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR088W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
11 structures for P38805
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5Z3G | EM | 365 A | O | 1-295 | PDB |
| 6C0F | EM | 370 A | I | 1-295 | PDB |
| 6CB1 | EM | 460 A | I | 1-295 | PDB |
| 6EM1 | EM | 360 A | x | 1-295 | PDB |
| 6EM3 | EM | 320 A | x | 1-295 | PDB |
| 6EM4 | EM | 410 A | x | 1-295 | PDB |
| 6EM5 | EM | 430 A | x | 1-295 | PDB |
| 7OHS | EM | 438 A | x | 1-295 | PDB |
| 7OHW | EM | 350 A | x | 1-295 | PDB |
| 7OHX | EM | 330 A | x | 1-295 | PDB |
| AF-P38805-F1 | Predicted | AlphaFoldDB |
No variants for P38805
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P38805 | |||||
No associated diseases with P38805
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| rRNA primary transcript binding | Binding to an unprocessed ribosomal RNA transcript. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of 5.8S rRNA | Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. |
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| maturation of LSU-rRNA | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| ribosomal large subunit export from nucleus | The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VKB4 | CG6712 | Probable ribosome production factor 1 | Drosophila melanogaster (Fruit fly) | PR |
| P54073 | F44G4.1 | Brix domain-containing protein F44G4.1 | Caenorhabditis elegans | PR |
| Q6IQU6 | rpf1 | Ribosome production factor 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALGNEINIT | NKLKRQEIFA | DIKHEKNKER | HTMRRKRAKE | ERENPELREQ | RLKENVTQTI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENTRVYDETI | NKEVEGDEDD | LMRYFNSNSN | EPPKIFLTTN | VNAKKSAYEF | ANILIEILPN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTFVKRKFGY | KLKEISDICI | KRNFTDIVII | NEDKKKVTGL | TFIHLPEGPT | FYFKLSSFVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VKKIVGHGRP | TSHIPELILN | NFQTRLGQTV | GRLFQSILPQ | NPDIEGRQVI | TLHNQRDYIF |
| 250 | 260 | 270 | 280 | 290 | |
| FRRHRYVFKD | NERVGLQELG | PQFTLKLKRL | QRGIKEETEW | EHKPEMDKEK | KKFYL |