Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6IQU6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6IQU6-F1 | Predicted | AlphaFoldDB |
No variants for Q6IQU6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6IQU6 | |||||
No associated diseases with Q6IQU6
1 regional properties for Q6IQU6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Brix domain | 123 - 306 | IPR007109 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| rRNA primary transcript binding | Binding to an unprocessed ribosomal RNA transcript. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of 5.8S rRNA | Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. |
| maturation of LSU-rRNA | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38805 | RPF1 | Ribosome production factor 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9VKB4 | CG6712 | Probable ribosome production factor 1 | Drosophila melanogaster (Fruit fly) | PR |
| P54073 | F44G4.1 | Brix domain-containing protein F44G4.1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAVKAPVEE | MDQAECEVKE | EKSASGPCFP | PTFSVSEIKN | KQRRHTMFLK | LKEEKRKKRM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELKKKKKKER | KALDDKAPPK | EVPKTIENQR | IYDETTVNPE | DEEVAFDEGT | DEFSAYFNRL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNPKVLITTS | DRPRGRTVRF | CDQLATVIPH | AYVYYRRGLA | LKKVIPQCIS | RGFTYLMVIN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDRKVPNGMV | LCHLPDGPTA | HFKVSSVRLR | KEMKRRGKNP | TEHSPEVILN | NFTTRLGHSI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRLFAALFPH | DPQFVGRQVA | TFHNQRDFIF | FRFHRYIFKN | EKKVGIQELG | PRFTLKLRSL |
| 310 | 320 | ||||
| QKGTFDSKFG | EYEWVHKRHE | MDSSRRKFHL |