Q9VHY5

PR
Gene name
Taf7 (anon-84Ec, TAF55, CG2670)
Protein name
Transcription initiation factor TFIID subunit 7
Names
Transcription initiation factor TFIID 55 kDa subunit, TAFII-55, TAFII55
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG2670
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

207-474 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VHY5

Entry ID Method Resolution Chain Position Source
AF-Q9VHY5-F1 Predicted AlphaFoldDB

No variants for Q9VHY5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VHY5

No associated diseases with Q9VHY5

1 regional properties for Q9VHY5

Type Name Position InterPro Accession
domain TAFII55 protein, conserved region 55 - 220 IPR006751

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

1 GO annotations of molecular function

Name Definition
RNA polymerase II general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.

2 GO annotations of biological process

Name Definition
RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9D3R9 Taf7l Transcription initiation factor TFIID subunit 7-like Mus musculus (Mouse) PR
B9DG24 TAF7 Transcription initiation factor TFIID subunit 7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPSLAVPHLT PISNEHLVSS KEVVFFWKNR IEMFEKKSDK VKQAEHKARD DGVELESQFI
70 80 90 100 110 120
MRVPKELADT VHEAINAGTI KDRLTIQLDP DLRYGEVRID DQILYTKLVD LPTVVESYKT
130 140 150 160 170 180
IDNKSFYKSA DICQILICKE EREDETEKES PNKNKKKDPN KVDKKYLFPH GITPPCKNVR
190 200 210 220 230 240
KRRFRKTLKK KNVEAPEIEK EVKHLLRIDN EAVRVDYEII NEEDKPMDEL EQSDIKPYND
250 260 270 280 290 300
ADDDLQDEST MHASEKTIME MSSQRHLQVE SDDDEASNFP SHRAPNMGVA VHDIFGEEVS
310 320 330 340 350 360
STDDEDEPDR GNNTMQRRVM EESSRLSADD SRMSDFFGAS GSNTGAGVVK MEQNVFSKSM
370 380 390 400 410 420
FGHEASSPKL SAAGSSSNLA APSGFYDSQM LAKREEFENM EFIDEPQPQY TQQQVQQKIN
430 440 450 460 470
QLTRQIRELK AQQVQKSTEI ASIQNATLKQ RMQETLDNLY TQVIERELEL KDFENMLES