Q9D3R9
Gene name |
Taf7l (Taf2q) |
Protein name |
Transcription initiation factor TFIID subunit 7-like |
Names |
TATA box binding protein-associated factor RNA polymerase II subunit Q, TATA box-binding protein-associated factor 50 kDa, Transcription initiation factor TFIID 50 kDa subunit |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74469 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D3R9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D3R9-F1 | Predicted | AlphaFoldDB |
39 variants for Q9D3R9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389482017 | 16 | G>R | No | EVA | |
| rs586722977 | 19 | V>A | No | EVA | |
| rs3411615071 | 20 | E>Q | No | EVA | |
| rs241529740 | 20 | E>V | No | EVA | |
| rs583962966 | 21 | A>V | No | EVA | |
| rs3412280675 | 25 | V>F | No | EVA | |
| rs235812871 | 52 | R>G | No | EVA | |
| rs243668633 | 64 | G>V | No | EVA | |
| rs226643944 | 76 | S>F | No | EVA | |
| rs214264014 | 79 | T>P | No | EVA | |
| rs247220015 | 103 | C>S | No | EVA | |
| rs3411853418 | 120 | Y>* | No | EVA | |
| rs3412195542 | 128 | S>P | No | EVA | |
| rs3411953628 | 134 | K>E | No | EVA | |
| rs3410566028 | 141 | F>S | No | EVA | |
| rs236798890 | 160 | K>R | No | EVA | |
| rs218016129 | 174 | I>V | No | EVA | |
| rs3389524856 | 189 | L>I | No | EVA | |
| rs265810144 | 209 | G>S | No | EVA | |
| rs239548225 | 215 | I>T | No | EVA | |
| rs3411615084 | 233 | P>S | No | EVA | |
| rs3389541815 | 237 | N>K | No | EVA | |
| rs3389576149 | 241 | K>* | No | EVA | |
| rs3411175198 | 245 | K>E | No | EVA | |
| rs3389541811 | 246 | T>I | No | EVA | |
| rs222689534 | 306 | M>I | No | EVA | |
| rs223904887 | 322 | D>E | No | EVA | |
| rs1135090632 | 339 | D>Y | No | EVA | |
| rs1132223950 | 340 | V>E | No | EVA | |
| rs1132681131 | 340 | V>L | No | EVA | |
| rs3389584320 | 363 | E>G | No | EVA | |
| rs3389541824 | 391 | E>V | No | EVA | |
| rs29267404 | 400 | T>I | No | EVA | |
| rs3389584340 | 408 | F>L | No | EVA | |
| rs3389575455 | 409 | I>N | No | EVA | |
| rs3389553756 | 438 | R>G | No | EVA | |
| rs29267411 | 442 | N>S | No | EVA | |
| rs262177328 | 455 | C>R | No | EVA | |
| rs213822709 | 467 | C>G | No | EVA |
No associated diseases with Q9D3R9
3 regional properties for Q9D3R9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Transcription factor, T-box, conserved site | 100 - 119 | IPR018186-1 |
| conserved_site | Transcription factor, T-box, conserved site | 174 - 192 | IPR018186-2 |
| domain | T-box transcription factor, DNA-binding domain | 90 - 278 | IPR046360 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| male germ cell nucleus | The nucleus of a male germ cell, a reproductive cell in males. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| RNA polymerase II preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. |
| spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERGEEAPTE | GAPPEGALVE | AKAPVIPEAP | ATDVSTTEEA | GSKEPQVPSG | PRPEGAGDTC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTRGARGPPT | PGRAKSQKTP | RQGTARCQTL | ESAMRSMSVR | LECHDVEEQF | ILRLPPEQAY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVRKIIHSRN | AAWKDKLKID | FSPDGHHAVV | QVDNVSLPAK | LVNLPCVIGS | LKTIDRKTFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTADVSQMLV | CSPEGEPHSP | PEEPVVSTGP | TVIGISEGKA | ERKKYNWKHG | ITPPLKNVRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRFRKTTKKL | PDVKQVDEIN | FSEYTQSPSV | EKEVKRLLYS | DAEAVSVRWE | VVDDDDAKEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESQGSMPTTP | GISQMGGASL | SDYDVFREMM | GDSGSNSNDV | EEKSNEGDDD | DDEDEDDEDY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GNEKEEEETD | NSEEELEKEL | QAKFNEFSLH | EADQDYSSIT | MAIQKLIFIK | EKRLQMIYKK |
| 430 | 440 | 450 | 460 | 470 | |
| AQRQKELLRK | VENLTLKRHF | QNVLGKLNIM | EKEKCEQIYH | LQEQLKCFLK | E |