Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for B9DG24

Entry ID Method Resolution Chain Position Source
AF-B9DG24-F1 Predicted AlphaFoldDB

20 variants for B9DG24

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13579295 28 S>C No 1000Genomes
ENSVATH14321644 32 P>L No 1000Genomes
ENSVATH01372838 34 D>N No 1000Genomes
ENSVATH04967906 36 F>C No 1000Genomes
ENSVATH04967904 38 S>* No 1000Genomes
ENSVATH04967905 38 S>P No 1000Genomes
tmp_1_20629000_C_A 39 E>D No 1000Genomes
ENSVATH13579271 45 T>K No 1000Genomes
ENSVATH04967900 47 M>I No 1000Genomes
ENSVATH01372836 148 F>L No 1000Genomes
ENSVATH13579269 162 L>I No 1000Genomes
ENSVATH01372835 166 N>K No 1000Genomes
tmp_1_20628371_A_C 168 I>S No 1000Genomes
ENSVATH04967892 173 F>L No 1000Genomes
tmp_1_20628310_C_A 188 M>I No 1000Genomes
ENSVATH00098482 221 N>S No 1000Genomes
ENSVATH04967891 232 I>N No 1000Genomes
ENSVATH04967890 233 Q>R No 1000Genomes
tmp_1_20628161_A_T 238 I>N No 1000Genomes
ENSVATH01372834 239 I>T No 1000Genomes

No associated diseases with B9DG24

1 regional properties for B9DG24

Type Name Position InterPro Accession
domain TAFII55 protein, conserved region 1 - 147 IPR006751

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VHY5 Taf7 Transcription initiation factor TFIID subunit 7 Drosophila melanogaster (Fruit fly) PR
Q9D3R9 Taf7l Transcription initiation factor TFIID subunit 7-like Mus musculus (Mouse) PR
10 20 30 40 50 60
MEEQFILRVP PSVSERIDRL LSEDASTSDE IPLDLFFSED GRNGTFMIGN DEFPASLLDL
70 80 90 100 110 120
PAVVESFKTY DDCALVKTAD IGQMIMVREP GDPAPNTVEY RHGLTPPMKD ARKRRFRREP
130 140 150 160 170 180
DLNPELVQRV ERDLLNILSG GTVENVSFSF YFRHMMCLYL LLGFSNFIYL NFFWCRYMSK
190 200 210 220 230
RNQLRTRMLV MQVRKYLLLH LHLLKSLKLL RQALVIQQEL NRREVNQKIL MIQCEFIII