Q9VCE6

PR
Gene name
Mettl3
Protein name
N6-adenosine-methyltransferase MT-A70-like protein
Names
Inducer of meiosis 4, Methyltransferase-like 3
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG5933
EC number
2.1.1.348: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VCE6

Entry ID Method Resolution Chain Position Source
AF-Q9VCE6-F1 Predicted AlphaFoldDB

No variants for Q9VCE6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VCE6

No associated diseases with Q9VCE6

No regional properties for Q9VCE6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9VCE6

Functions

Description
EC Number 2.1.1.348 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA N6-methyladenosine methyltransferase complex A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).

4 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am.
mRNA (N6-adenosine)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.
RNA binding Binding to an RNA molecule or a portion thereof.

10 GO annotations of biological process

Name Definition
dosage compensation Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
female sex determination The specification of female sex of an individual organism.
germarium-derived female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.
mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
ovarian follicle cell development The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
sex determination Any process that establishes and transmits the specification of sexual status of an individual organism.
sex differentiation The establishment of the sex of an organism by physical differentiation.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86U44 METTL3 N6-adenosine-methyltransferase catalytic subunit Homo sapiens (Human) PR
Q8C3P7 Mettl3 N6-adenosine-methyltransferase subunit METTL3 Mus musculus (Mouse) PR
O82486 MTA N6-adenosine-methyltransferase MT-A70-like Arabidopsis thaliana (Mouse-ear cress) PR
F1R777 mettl3 N6-adenosine-methyltransferase subunit METTL3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MADAWDIKSL KTKRNTLREK LEKRKKERIE ILSDIQEDLT NPKKELVEAD LEVQKEVLQA
70 80 90 100 110 120
LSSCSLALPI VSTQVVEKIA GSSLEMVNFI LGKLANQGAI VIRNVTIGTE AGCEIISVQP
130 140 150 160 170 180
KELKEILEDT NDTCQQKEEE AKRKLEVDDV DQPQEKTIKL ESTVARKEST SLDAPDDIMM
190 200 210 220 230 240
LLSMPSTREK QSKQVGEEIL ELLTKPTAKE RSVAEKFKSH GGAQVMEFCS HGTKVECLKA
250 260 270 280 290 300
QQATAEMAAK KKQERRDEKE LRPDVDAGEN VTGKVPKTES AAEDGEIIAE VINNCEAESQ
310 320 330 340 350 360
ESTDGSDTCS SETTDKCTKL HFKKIIQAHT DESLGDCSFL NTCFHMATCK YVHYEVDTLP
370 380 390 400 410 420
HINTNKPTDV KTKLSLKRSV DSSCTLYPPQ WIQCDLRFLD MTVLGKFAVV MADPPWDIHM
430 440 450 460 470 480
ELPYGTMSDD EMRALGVPAL QDDGLIFLWV TGRAMELGRD CLKLWGYERV DELIWVKTNQ
490 500 510 520 530 540
LQRIIRTGRT GHWLNHGKEH CLVGMKGNPT NLNRGLDCDV IVAEVRATSH KPDEIYGIIE
550 560 570 580 590 600
RLSPGTRKIE LFGRPHNIQP NWITLGNQLD GIRLVDPELI TQFQKRYPDG NCMSPASANA
ASINGIQK