O82486
PR
Gene name |
MTA |
Protein name |
N6-adenosine-methyltransferase MT-A70-like |
Names |
Protein EMBRYO DEFECTIVE 1706, Protein METTL3 homolog |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G10760 |
EC number |
2.1.1.348: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O82486
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O82486-F1 | Predicted | AlphaFoldDB |
38 variants for O82486
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_6623306_T_C | 3 | T>A | No | 1000Genomes | |
| tmp_4_6623294_C_T | 7 | D>N | No | 1000Genomes | |
| tmp_4_6623290_G_T | 8 | A>D | No | 1000Genomes | |
| ENSVATH00487639 | 11 | T>N | No | 1000Genomes | |
| tmp_4_6623279_C_T | 12 | V>I | No | 1000Genomes | |
| ENSVATH14127063 | 14 | K>E | No | 1000Genomes | |
| ENSVATH06608464 | 18 | V>A | No | 1000Genomes | |
| ENSVATH02779893 | 41 | I>V | No | 1000Genomes | |
| tmp_4_6623090_C_A | 75 | V>F | No | 1000Genomes | |
| tmp_4_6623069_T_G | 82 | I>L | No | 1000Genomes | |
| tmp_4_6623051_G_T | 88 | Q>K | No | 1000Genomes | |
| tmp_4_6623030_G_T | 95 | H>N | No | 1000Genomes | |
| tmp_4_6623013_C_T | 100 | M>I | No | 1000Genomes | |
| ENSVATH06608462 | 157 | A>V | No | 1000Genomes | |
| ENSVATH06608457 | 187 | G>A | No | 1000Genomes | |
| ENSVATH06608455 | 220 | F>L | No | 1000Genomes | |
| ENSVATH02779885 | 226 | S>L | No | 1000Genomes | |
| ENSVATH00487638 | 228 | R>Q | No | 1000Genomes | |
| tmp_4_6622618_G_A | 232 | T>M | No | 1000Genomes | |
| tmp_4_6622606_A_T | 236 | I>N | No | 1000Genomes | |
| ENSVATH11466589 | 243 | G>C | No | 1000Genomes | |
| tmp_4_6622580_C_T | 245 | G>R | No | 1000Genomes | |
| tmp_4_6622565_C_T | 250 | G>R | No | 1000Genomes | |
| ENSVATH02779883 | 254 | F>C | No | 1000Genomes | |
| ENSVATH02779883 | 254 | F>Y | No | 1000Genomes | |
| ENSVATH06608451 | 255 | P>Q | No | 1000Genomes | |
| tmp_4_6622522_G_C | 264 | P>R | No | 1000Genomes | |
| ENSVATH06608450 | 266 | M>T | No | 1000Genomes | |
| tmp_4_6622468_C_T | 282 | G>E | No | 1000Genomes | |
| tmp_4_6622457_G_A | 286 | P>S | No | 1000Genomes | |
| ENSVATH06608448 | 304 | V>A | No | 1000Genomes | |
| tmp_4_6622403_C_T | 304 | V>I | No | 1000Genomes | |
| ENSVATH00487629 | 432 | D>E | No | 1000Genomes | |
| tmp_4_6620923_G_A | 441 | A>V | No | 1000Genomes | |
| ENSVATH11466338 | 640 | V>I | No | 1000Genomes | |
| tmp_4_6620039_G_A | 656 | P>S | No | 1000Genomes | |
| tmp_4_6620034_T_A | 657 | E>D | No | 1000Genomes | |
| tmp_4_6619963_T_G | 681 | D>A | No | 1000Genomes |
No associated diseases with O82486
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.348 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA N6-methyladenosine methyltransferase complex | A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| mRNA (N6-adenosine)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| mRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. |
| RNA methylation | Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VCE6 | Mettl3 | N6-adenosine-methyltransferase MT-A70-like protein | Drosophila melanogaster (Fruit fly) | PR |
| Q86U44 | METTL3 | N6-adenosine-methyltransferase catalytic subunit | Homo sapiens (Human) | PR |
| Q8C3P7 | Mettl3 | N6-adenosine-methyltransferase subunit METTL3 | Mus musculus (Mouse) | PR |
| F1R777 | mettl3 | N6-adenosine-methyltransferase subunit METTL3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METESDDATI | TVVKDMRVRL | ENRIRTQHDA | HLDLLSSLQS | IVPDIVPSLD | LSLKLISSFT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRPFVATPPL | PEPKVEKKHH | PIVKLGTQLQ | QLHGHDSKSM | LVDSNQRDAE | ADGSSGSPMA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVRAMVAECL | LQRVPFSPTD | SSTVLRKLEN | DQNARPAEKA | ALRDLGGECG | PILAVETALK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMAEENGSVE | LEEFEVSGKP | RIMVLAIDRT | RLLKELPESF | QGNNESNRVV | ETPNSIENAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VSGGGFGVSG | SGNFPRPEMW | GGDPNMGFRP | MMNAPRGMQM | MGMHHPMGIM | GRPPPFPLPL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLPVPSNQKL | RSEEEDLKDV | EALLSKKSFK | EKQQSRTGEE | LLDLIHRPTA | KEAATAAKFK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SKGGSQVKYY | CRYLTKEDCR | LQSGSHIACN | KRHFRRLIAS | HTDVSLGDCS | FLDTCRHMKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CKYVHYELDM | ADAMMAGPDK | ALKPLRADYC | SEAELGEAQW | INCDIRSFRM | DILGTFGVVM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ADPPWDIHME | LPYGTMADDE | MRTLNVPSLQ | TDGLIFLWVT | GRAMELGREC | LELWGYKRVE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EIIWVKTNQL | QRIIRTGRTG | HWLNHSKEHC | LVGIKGNPEV | NRNIDTDVIV | AEVRETSRKP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DEMYAMLERI | MPRARKLELF | ARMHNAHAGW | LSLGNQLNGV | RLINEGLRAR | FKASYPEIDV |
| 670 | 680 | ||||
| QPPSPPRASA | METDNEPMAI | DSITA |