AiPD: Autoinhibited Protein Database

Q9UQ80

Gene name	PA2G4 (EBP1)
Protein name	Proliferation-associated protein 2G4
Names	Cell cycle protein p38-2G4 homolog, hG4-1, ErbB3-binding protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5036
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

218-293 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

218-293 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

15 structures for Q9UQ80

Entry ID	Method	Resolution	Chain	Position	Source
2Q8K	X-ray	160 A	A	2-394	PDB
3J2I	EM	1190 A	A	1-394	PDB
6CHT	X-ray	317 A	C/F/I/L	349-368	PDB
6LSR	EM	313 A	z	1-394	PDB
6SXO	EM	330 A	A	1-394	PDB
6WM8	X-ray	260 A	A/B/C	2-362	PDB
6Z6L	EM	300 A	CA	1-394	PDB
6Z6M	EM	310 A	CA	1-394	PDB
6Z6N	EM	290 A	CA	1-394	PDB
6ZM7	EM	270 A	CA	1-394	PDB
6ZME	EM	300 A	CA	1-394	PDB
6ZMI	EM	260 A	CA	1-394	PDB
6ZMO	EM	310 A	CA	1-394	PDB
7BHP	EM	330 A	A	1-394	PDB
AF-Q9UQ80-F1	Predicted				AlphaFoldDB

144 variants for Q9UQ80

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA385326684 rs1359795464	2	S>P		No	ClinGen TOPMed
CA385326699 rs747250149	3	G>D		No	ClinGen ExAC TOPMed gnomAD
rs747250149 CA6623148	3	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1300108107 CA385326716	4	E>D		No	ClinGen gnomAD
rs1226822777 CA385326731	5	D>E		No	ClinGen gnomAD
rs770956250 CA6623149	5	D>G		No	ClinGen ExAC gnomAD
CA385326790 rs1390301075	8	Q>*		No	ClinGen gnomAD
CA385326798 rs1455560035	8	Q>L		No	ClinGen TOPMed
rs1256611986 CA385326807	9	E>Q		No	ClinGen gnomAD
CA385326923 rs1384371556	14	E>D		No	ClinGen TOPMed gnomAD
rs1187712298 CA385326953	16	L>V		No	ClinGen TOPMed
rs1592234525 CA385326983	17	V>G		No	ClinGen Ensembl
rs1188903304 CA385327081	22	K>M		No	ClinGen gnomAD
CA6623153 rs144476801	23	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
rs1592234542 CA385327195	28	A>T		No	ClinGen Ensembl
CA385327206 rs1447247472	28	A>V		No	ClinGen gnomAD
CA385327764 rs772926383	33	R>P		No	ClinGen ExAC TOPMed gnomAD
CA6623180 rs772926383	33	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6623182 rs765932783	35	L>M		No	ClinGen ExAC gnomAD
CA237634406 rs71459343	42	G>S		No	ClinGen gnomAD
CA6623184 rs763489054	45	V>L		No	ClinGen ExAC gnomAD
CA385327926 rs1342340629	47	S>I		No	ClinGen gnomAD
CA385327943 rs1233375738	50	E>Q		No	ClinGen TOPMed
rs1231686003 CA385328006	54	A>G		No	ClinGen TOPMed gnomAD
rs1231686003 CA385328004	54	A>V		No	ClinGen TOPMed gnomAD
CA6623185 rs764417136	56	I>M		No	ClinGen ExAC TOPMed gnomAD
rs150178932 CA6623186	57	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757495162 CA6623187	60	T>I		No	ClinGen ExAC gnomAD
rs767567758 CA6623188	62	K>E		No	ClinGen ExAC gnomAD
rs1325438406 CA385328118	63	I>V		No	ClinGen TOPMed
rs1565864011 CA385328181	67	E>*		No	ClinGen Ensembl
rs1168359617 CA385328270	73	G>S		No	ClinGen gnomAD
rs148811324 CA6623214	74	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1026132241 CA237634752	79	S>N		No	ClinGen TOPMed
CA385328417 rs1278287867	80	I>V		No	ClinGen TOPMed
rs984984418 CA237634763	82	V>I		No	ClinGen Ensembl
rs908870365 CA237634769	86	V>I		No	ClinGen Ensembl
CA385328623 rs1219296678	92	L>F		No	ClinGen gnomAD
rs565003154 CA237634780	93	K>R		No	ClinGen Ensembl
rs948397871 CA237634785	95	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs778940396 CA6623218	99	I>V		No	ClinGen ExAC TOPMed gnomAD
CA237634792 rs980340247	100	L>F		No	ClinGen Ensembl
CA6623219 rs114268672	106	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6623234 rs772303778	109	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6623235 rs773685227	110	L>I		No	ClinGen ExAC gnomAD
CA385329256 rs1322503711	118	I>V		No	ClinGen gnomAD
rs1266911478 CA385329275	119	A>G		No	ClinGen gnomAD
COSM166719 CA385329268 rs1592235275	119	A>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
CA385329381 rs754128407	125	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	128	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1565864140 CA385330049	129	V>A		No	ClinGen Ensembl
rs1168616877 CA385330137	132	G>E		No	ClinGen gnomAD
CA6623251 rs772704689	133	T>P		No	ClinGen ExAC gnomAD
CA385330152 rs1185101770	133	T>S		No	ClinGen TOPMed
CA237635003 rs773987525	138	R>K		No	ClinGen Ensembl
CA237635010 rs941114737	139	K>R		No	ClinGen TOPMed
CA237635014 rs368713215	140	A>T		No	ClinGen ESP TOPMed
rs773599039 CA6623252	142	V>I		No	ClinGen ExAC gnomAD
TCGA novel	143	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs969725312 CA237635022	153	A>V		No	ClinGen Ensembl
CA385330490 rs1313191144	155	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	161	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	162	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385330695 rs1297982162	164	T>A		No	ClinGen TOPMed gnomAD
rs1041473162 CA237635857	164	T>I		No	ClinGen Ensembl
TCGA novel	167	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6623266 rs551324670	171	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6623267 rs377104846	172	K>E		No	ClinGen ESP ExAC gnomAD
rs1333861475 CA385330836	174	A>G		No	ClinGen TOPMed
rs754462853 CA6623268	175	H>N		No	ClinGen ExAC TOPMed gnomAD
CA385330876 rs1408490772	180	T>A		No	ClinGen TOPMed
CA6623270 rs200413925	180	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6623272 rs367753477	182	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA385330915 rs1263402549	183	E>*		No	ClinGen gnomAD
rs768750897 CA6623295	186	L>P		No	ClinGen ExAC gnomAD
rs761734734 CA6623297	188	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA385331815 rs1367589959	196	D>N		No	ClinGen TOPMed gnomAD
CA6623298 rs767374029	198	E>Q		No	ClinGen ExAC gnomAD
rs778183934 CA237636230	204	N>S		No	ClinGen Ensembl
rs760410535 CA237636235	210	K>M		No	ClinGen ExAC TOPMed gnomAD
rs760410535 CA6623300	210	K>R		No	ClinGen ExAC TOPMed gnomAD
CA385332076 rs1354720893	212	D>E		No	ClinGen TOPMed
rs34197050	216	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	218	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385332190 rs1220341111	221	H>Y		No	ClinGen gnomAD
CA385332274 rs1307543120	228	V>I		No	ClinGen gnomAD
rs1207313100 CA385332288	229	L>F		No	ClinGen gnomAD
rs11549086 CA6623326	230	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6623328 rs760567113	234	E>D		No	ClinGen ExAC gnomAD
CA385332398 rs1223334854	237	A>S		No	ClinGen TOPMed
CA385332450 rs1308430550	240	A>S		No	ClinGen Ensembl
TCGA novel	242	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	245	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs367700438 COSM3704274 CA6623348	246	I>V	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs1171359272 CA385332620	250	D>A		No	ClinGen gnomAD
rs775245696 CA6623351	261	T>A		No	ClinGen ExAC gnomAD
rs1468032069 CA385332843	263	R>H		No	ClinGen gnomAD
CA385332911 rs1440304969	267	S>T		No	ClinGen gnomAD
TCGA novel	275	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385333101 rs1174918188	277	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	282	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM673813 rs959607996 CA237636789	297	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA237636798 rs138795633	307	V>I		No	ClinGen ESP TOPMed gnomAD
rs757246439 CA6623381	308	L>F		No	ClinGen ExAC gnomAD
rs781375175 CA6623382	309	Y>C		No	ClinGen ExAC gnomAD
rs1330130462 CA385333733	312	E>A		No	ClinGen gnomAD
CA385333741 rs1187413163	313	G>S		No	ClinGen TOPMed gnomAD
rs1219974885 CA385333923	327	P>L		No	ClinGen TOPMed
rs751702019 CA6623402	328	N>H		No	ClinGen ExAC gnomAD
rs762145974 CA6623403	328	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1471018063 CA385333943	330	P>L		No	ClinGen TOPMed gnomAD
CA385333953 rs1205252856	331	M>I		No	ClinGen gnomAD
COSM3398886 CA385333960 rs1253561691	332	R>W	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
rs371016159 CA6623405	335	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs756275049 CA385334025	337	P>A		No	ClinGen ExAC TOPMed gnomAD
rs756275049 CA6623406	337	P>S		No	ClinGen ExAC TOPMed gnomAD
CA237636959 rs968513268	339	E>K		No	ClinGen TOPMed gnomAD
rs138090957 CA385334068	340	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138090957 CA6623408	340	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs531365781 CA6623409	344	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6623410 rs778814972	345	S>C		No	ClinGen ExAC gnomAD
rs747740989 CA6623411	348	E>D		No	ClinGen ExAC gnomAD
rs777291456 CA6623413	352	A>P		No	ClinGen ExAC gnomAD
CA237637182 rs1018968003	356	A>V		No	ClinGen TOPMed gnomAD
CA385334849 rs1208555777	357	L>F		No	ClinGen gnomAD
rs1267175494 CA385334905	363	S>C		No	ClinGen gnomAD
rs1184260509 CA385334916	364	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	366	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385334950 rs1439191167	367	Q>K		No	ClinGen gnomAD
TCGA novel	369	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385335040 rs1426522769 COSM941504	372	K>N	endometrium Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs746871475	372	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1174297940	373	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	373	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6623446 rs114006569	373	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385335224 rs1255423528	377	T>I		No	ClinGen gnomAD
CA237638139 rs969183779	385	E>D		No	ClinGen Ensembl
CA385335290 rs1592236948	385	E>G		No	ClinGen Ensembl
rs576915957 CA6623477	385	E>K		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	388	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464848883 CA385335319	389	E>V		No	ClinGen gnomAD
CA237638145 rs759262787	391	E>Q		No	ClinGen Ensembl
TCGA novel	394	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	395	D>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q9UQ80

2 regional properties for Q9UQ80

Type	Name	Position	InterPro Accession
domain	Peptidase M24	21 - 228	IPR000994
binding_site	Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site	104 - 120	IPR018349

Functions

		Description
EC Number
Subcellular Localization	[Isoform 1]: Cytoplasm Nucleus, nucleolus	Translocates to the nucleus upon treatment with HRG Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
azurophil granule lumen	The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name	Definition
nucleic acid binding	Binding to a nucleic acid.
RNA binding	Binding to an RNA molecule or a portion thereof.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

5 GO annotations of biological process

Name	Definition
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of cell differentiation	Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of translation	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P50580	Pa2g4	Proliferation-associated protein 2G4	Mus musculus (Mouse)	PR
Q6AYD3	Pa2g4	Proliferation-associated protein 2G4	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSGEDEQQEQ	TIAEDLVVTK	YKMGGDIANR	VLRSLVEASS	SGVSVLSLCE	KGDAMIMEET
70	80	90	100	110	120
GKIFKKEKEM	KKGIAFPTSI	SVNNCVCHFS	PLKSDQDYIL	KEGDLVKIDL	GVHVDGFIAN
130	140	150	160	170	180
VAHTFVVDVA	QGTQVTGRKA	DVIKAAHLCA	EAALRLVKPG	NQNTQVTEAW	NKVAHSFNCT
190	200	210	220	230	240
PIEGMLSHQL	KQHVIDGEKT	IIQNPTDQQK	KDHEKAEFEV	HEVYAVDVLV	SSGEGKAKDA
250	260	270	280	290	300
GQRTTIYKRD	PSKQYGLKMK	TSRAFFSEVE	RRFDAMPFTL	RAFEDEKKAR	MGVVECAKHE
310	320	330	340	350	360
LLQPFNVLYE	KEGEFVAQFK	FTVLLMPNGP	MRITSGPFEP	DLYKSEMEVQ	DAELKALLQS
370	380	390
SASRKTQKKK	KKKASKTAEN	ATSGETLEEN	EAGD