Q6AYD3

PR
Gene name
Pa2g4
Protein name
Proliferation-associated protein 2G4
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:288778
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

320-394 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AYD3

Entry ID Method Resolution Chain Position Source
AF-Q6AYD3-F1 Predicted AlphaFoldDB

No variants for Q6AYD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AYD3

No associated diseases with Q6AYD3

2 regional properties for Q6AYD3

Type Name Position InterPro Accession
domain Peptidase M24 21 - 228 IPR000994
binding_site Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site 104 - 120 IPR018349

Functions

Description
EC Number
Subcellular Localization
  • [Isoform 1]: Cytoplasm
  • Nucleus, nucleolus
  • Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name Definition
nucleic acid binding Binding to a nucleic acid.
RNA binding Binding to an RNA molecule or a portion thereof.
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

5 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UQ80 PA2G4 Proliferation-associated protein 2G4 Homo sapiens (Human) PR
P50580 Pa2g4 Proliferation-associated protein 2G4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET
70 80 90 100 110 120
GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN
130 140 150 160 170 180
VAHTFVIGVA QGSQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT
190 200 210 220 230 240
PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA
250 260 270 280 290 300
GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE
310 320 330 340 350 360
LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS
370 380 390
SASRKTQKKK KKKASKTAEN ATSGETLEEN GAGD