AiPD: Autoinhibited Protein Database

Q9ULI2

Gene name	RIMKLB (FAM80B, KIAA1238)
Protein name	Beta-citrylglutamate synthase B
Names	N-acetyl-aspartylglutamate synthetase B, NAAG synthetase B, NAAGS, Ribosomal protein S6 modification-like protein B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57494
EC number	6.3.1.17: Acid--ammonia (or amine) ligases (amide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

285-386 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

285-386 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9ULI2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9ULI2-F1	Predicted				AlphaFoldDB

223 variants for Q9ULI2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA6434862 rs758374737	2	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	3	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	6	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384042145 rs1396900755	7	A>G		No	ClinGen gnomAD
rs779819698 CA6434863	8	K>N		No	ClinGen ExAC TOPMed gnomAD
rs892913162 CA232329477	10	W>*		No	ClinGen Ensembl
CA384042200 rs1288334283	15	R>C		No	ClinGen TOPMed gnomAD
CA384042201 rs746850279	15	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6434864 rs746850279	15	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1288334283 CA384042198	15	R>S		No	ClinGen TOPMed gnomAD
rs768420758 CA6434865	16	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1233617997 CA384042215	18	R>G		No	ClinGen gnomAD
CA232329500 rs372596598	21	Y>C		No	ClinGen ESP TOPMed gnomAD
rs1274691538 CA384042239	21	Y>H		No	ClinGen gnomAD
rs377131188 CA232329501	25	E>Q		No	ClinGen TOPMed gnomAD
rs1214512443 CA384042292	28	R>Q		No	ClinGen gnomAD
rs747795942 CA6434867	29	A>T		No	ClinGen ExAC gnomAD
CA384042323 rs1255953972	33	K>I		No	ClinGen gnomAD
CA384042380 rs1420343502	41	F>I		No	ClinGen gnomAD
rs200383619 CA6434872	41	F>L		No	ClinGen ExAC TOPMed gnomAD
rs761178360 CA6434873	42	R>S		No	ClinGen ExAC gnomAD
CA384042399 rs1345857540	44	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	45	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1455351989 CA384042415	46	M>T		No	ClinGen TOPMed gnomAD
CA232329575 rs775159268	49	V>M		No	ClinGen TOPMed gnomAD
CA384042459 rs1354690634	53	I>V		No	ClinGen TOPMed gnomAD
CA6434875 rs754185655	54	E>K		No	ClinGen ExAC gnomAD
rs1442367283 CA384042479	55	Q>H		No	ClinGen gnomAD
rs762104772 CA6434876	56	G>A		No	ClinGen ExAC TOPMed gnomAD
CA383811356 rs1281260727 COSM263341	60	L>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA383811362 rs1424474258	61	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs61999314 CA6434894	63	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773288313 CA6434896	68	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs369858388 CA383811409	68	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6434897 rs369858388	68	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6434898 rs766445449	72	Q>E		No	ClinGen ExAC gnomAD
CA383811447 rs1454711969	74	V>A		No	ClinGen gnomAD
rs373818718 CA232629062	75	V>I		No	ClinGen ESP
CA383811460 rs1175450736	77	R>G		No	ClinGen gnomAD
rs1409187820 CA383811498	82	W>C		No	ClinGen gnomAD
rs1329260523 CA383811517	85	S>N		No	ClinGen TOPMed gnomAD
TCGA novel	87	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	93	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755841859 CA6434903	98	M>V		No	ClinGen ExAC TOPMed gnomAD
CA383811616 rs1442394564	99	G>R		No	ClinGen gnomAD
CA6434904 rs777538451	99	G>V		No	ClinGen ExAC gnomAD
CA6434905 rs746816555	101	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1591883342 CA383811653	104	N>T		No	ClinGen Ensembl
CA232629086 rs375693846	105	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs778576626 CA6434907	107	Q>R		No	ClinGen ExAC
CA6434910 rs777249185	113	V>I		No	ClinGen ExAC TOPMed gnomAD
CA383811740 rs1240324872	117	W>R		No	ClinGen gnomAD
rs1421387017 CA383811757	119	F>C		No	ClinGen gnomAD
CA6434912 rs770046248	119	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	122	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383811785 rs1163779323	123	A>S		No	ClinGen gnomAD
TCGA novel	123	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA232629116 rs1047404419	125	H>R		No	ClinGen TOPMed gnomAD
rs377544500 CA6434914	125	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	126	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383811829 rs1565613517 COSM1364734	130	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
TCGA novel	132	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774439334 CA6434916	135	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	140	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	145	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6434935 rs772132023	146	D>G		No	ClinGen ExAC gnomAD
TCGA novel	146	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA232630009 rs374438568	147	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	150	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753604050 CA6434939	152	E>A		No	ClinGen ExAC TOPMed gnomAD
rs200372425 CA6434940	155	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM431951 CA383812052 rs1591895998	160	T>M	lung large_intestine breast [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1470222763 CA383812055	161	R>Q		No	ClinGen gnomAD
CA383812054 rs1362804825	161	R>W		No	ClinGen gnomAD
TCGA novel	162	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	166	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375314643 CA232631229	171	A>V		No	ClinGen ESP
CA383812137 rs778474066 COSM1364736	172	R>*	large_intestine Variant assessed as Somatic; 4.639e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs778474066 CA6434957	172	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs369058701 CA6434958	172	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6434959 rs765122719	173	D>G		No	ClinGen ExAC TOPMed gnomAD
rs183093573 CA6434960	174	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA232631233 rs1014860280	175	H>R		No	ClinGen Ensembl
rs61740936 CA6434961	178	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs148505080 CA6434962	178	A>V		No	ClinGen 1000Genomes ExAC TOPMed
rs1250535928 CA383812188	180	L>V		No	ClinGen gnomAD
CA383812196 rs1339739591	181	S>N		No	ClinGen gnomAD
rs1250690951 CA383812204 COSM469022	182	H>R	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6434964 rs754482681	184	I>F		No	ClinGen ExAC gnomAD
COSM944265 rs1591908407 CA383812223	185	R>C	lung large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA6434965 rs764559762	185	R>H		No	ClinGen ExAC gnomAD
rs1328171553 CA383812226	186	H>N		No	ClinGen TOPMed
CA383812230 rs1268715870	186	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA232631259 rs1005405168	187	E>K		No	ClinGen TOPMed gnomAD
COSM944266 rs754337339 CA6434966	188	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1565618766 CA383812275	193	Q>*		No	ClinGen Ensembl
rs1461022472 CA383812317	198	E>D		No	ClinGen TOPMed gnomAD
CA383812311 rs1392500127	198	E>K		No	ClinGen gnomAD
CA6434969 rs746179407	201	G>E		No	ClinGen ExAC gnomAD
CA6434970 rs758576248	202	R>L		No	ClinGen ExAC gnomAD
rs1294685963 CA383812356	205	R>C		No	ClinGen gnomAD
CA6434972 rs780288602	208	V>A		No	ClinGen ExAC gnomAD
COSM944267 CA383812380 rs1270918303	209	V>M	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs768771331 CA6434974	210	G>A		No	ClinGen ExAC gnomAD
CA383812394 rs1266687362	211	G>D		No	ClinGen gnomAD
rs373258265 CA6434976	212	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA6434977 rs748105863	212	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1243261523 CA383812411	214	V>A		No	ClinGen TOPMed
rs1416018731 CA383812422	216	T>N		No	ClinGen TOPMed gnomAD
rs760713274 CA6434978	218	L>*		No	ClinGen ExAC gnomAD
rs1474994941 CA383812435	218	L>V		No	ClinGen gnomAD
rs377695054 CA6434979	222	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA232631296 rs976068380	222	T>K		No	ClinGen Ensembl
CA383812469 rs1565402191	223	D>G		No	ClinGen Ensembl
TCGA novel	223	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762796823 CA6434981	228	S>G		No	ClinGen ExAC gnomAD
rs765989645 CA6434982	231	S>*		No	ClinGen ExAC gnomAD
CA383812533 rs1212640580	232	L>*		No	ClinGen TOPMed
rs1239471931 CA383814298	237	M>L		No	ClinGen gnomAD
rs1180579466 CA383814322	238	M>I		No	ClinGen gnomAD
rs1479768934 CA383814315	238	M>V		No	ClinGen gnomAD
rs1238864324 CA383814338	239	C>W		No	ClinGen gnomAD
CA383814331 rs1176748201	239	C>Y		No	ClinGen gnomAD
rs763297463 CA383814340	240	S>A		No	ClinGen ExAC TOPMed gnomAD
rs763297463 CA6435013	240	S>P		No	ClinGen ExAC TOPMed gnomAD
rs1411603144 CA383814374	242	S>N		No	ClinGen TOPMed
TCGA novel	246	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779467477 CA6435017	254	N>D		No	ClinGen 1000Genomes ExAC gnomAD
rs752865143 CA6435018	256	L>P		No	ClinGen ExAC gnomAD
rs1180684899 CA383814602	259	D>G		No	ClinGen TOPMed
rs2969089 CA383814675 CA383814672	264	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383814690 rs2302488	266	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383814738 rs1450146679	269	D>E		No	ClinGen TOPMed
CA6435024 rs745610268	269	D>G		No	ClinGen ExAC gnomAD
CA6435026 rs775097310	271	G>S	Variant assessed as Somatic; 4.638e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1335274924 CA383814753	271	G>V		No	ClinGen TOPMed
rs1306053301 CA603490302	272	S>N		No	ClinGen gnomAD
CA6435028 rs768147219	275	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6435029 rs768147219	275	V>I		No	ClinGen ExAC TOPMed gnomAD
rs763533051 CA6435030	279	N>S		No	ClinGen ExAC
rs766750882 CA6435031	284	F>C		No	ClinGen ExAC gnomAD
rs751989687 CA6435032	285	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1252347652 CA383814899	285	I>V		No	ClinGen gnomAD
CA6435034 rs767902044	286	A>T		No	ClinGen ExAC gnomAD
rs1279691882 CA383814930	287	F>C		No	ClinGen TOPMed
rs1417129841 CA383814937	288	D>H		No	ClinGen gnomAD
rs752955177 CA6435035	289	K>E		No	ClinGen ExAC gnomAD
CA6435036 rs756330321	290	A>S		No	ClinGen ExAC
CA383814986 rs1435105194	291	C>S		No	ClinGen TOPMed
rs778010986 CA6435037	294	D>N		No	ClinGen ExAC gnomAD
CA383815006 rs1565429989	294	D>V		No	ClinGen Ensembl
CA383815024 rs1328787634	297	G>D		No	ClinGen TOPMed
rs753810070 CA6435038	298	I>M		No	ClinGen ExAC gnomAD
TCGA novel	299	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs982747575 CA232644085 CA383815052	301	D>E		No	ClinGen TOPMed gnomAD
CA383815054 rs1157365838	302	Y>H		No	ClinGen TOPMed
rs181443607 CA6435042	304	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779746622 CA6435043	305	S>T		No	ClinGen ExAC gnomAD
TCGA novel	306	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1258986746 CA383815083	307	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	307	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	308	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	309	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776230676 CA383815120	310	G>A		No	ClinGen ExAC gnomAD
rs776230676 CA6435046	310	G>D		No	ClinGen ExAC gnomAD
rs746088886 CA232644127	311	R>Q		No	ClinGen 1000Genomes TOPMed gnomAD
CA6435047 rs761192471	311	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6435048 rs760873000	313	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383815145 rs1592028544	313	T>P		No	ClinGen Ensembl
CA6435049 rs760873000	313	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383815157 rs1565430225	314	R>Q		No	ClinGen Ensembl
rs201378504 CA6435050 COSM297710	314	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA383815162 rs1425389132 COSM1364739	315	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs767992050 CA6435051	315	R>H		No	ClinGen ExAC TOPMed gnomAD
rs775937341 CA6435052	316	M>I		No	ClinGen ExAC gnomAD
CA383815182 rs1258835058	316	M>K		No	ClinGen gnomAD
TCGA novel	318	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6435054 rs55776242	321	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6435055 rs55776242	321	V>M		No	ClinGen ExAC TOPMed gnomAD
CA383815278 rs1399830216	324	T>A		No	ClinGen gnomAD
rs1399830216 CA383815276	324	T>P		No	ClinGen gnomAD
CA6435059 rs185884970	328	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA6435060 COSM4148988 rs749377963	331	P>L	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6435063 rs780682229	335	P>A		No	ClinGen ExAC TOPMed gnomAD
CA6435064 rs780682229	335	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6435065 rs769174759	336	P>Q		No	ClinGen ExAC gnomAD
TCGA novel	337	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774991258 CA6435066	337	A>V		No	ClinGen ExAC gnomAD
TCGA novel	339	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383815475 rs1484530525	340	A>P		No	ClinGen gnomAD
CA383815483 rs1186421150	340	A>V		No	ClinGen TOPMed gnomAD
rs1481819439 CA383815518	343	N>S		No	ClinGen Ensembl
CA383815533 rs1346092837	344	M>T		No	ClinGen TOPMed
rs1258168251 CA383815571	347	S>G		No	ClinGen gnomAD
TCGA novel	347	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6435070 rs761088763	348	S>C		No	ClinGen ExAC gnomAD
rs1592029254 CA383815612	350	S>C		No	ClinGen Ensembl
CA232644215 rs764486376	351	V>A		No	ClinGen Ensembl
rs1156276862 CA383815616	351	V>F		No	ClinGen gnomAD
CA383815623 rs1565430569	352	D>G		No	ClinGen Ensembl
TCGA novel	355	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs188393703 CA6435074	358	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6435075 rs188393703	358	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6435081 rs754746293	360	R>*		No	ClinGen ExAC gnomAD
rs754746293 CA6435079	360	R>G		No	ClinGen ExAC gnomAD
rs1341261739 CA383815716	360	R>Q		No	ClinGen gnomAD
CA383815742 rs1449162438	362	L>P		No	ClinGen TOPMed
rs1247145087 CA383815753	363	L>R		No	ClinGen gnomAD
rs1388534303 CA383815747	363	L>V		No	ClinGen TOPMed
rs777168606 CA6435083	364	T>I		No	ClinGen ExAC gnomAD
CA6435082 rs755726796	364	T>S		No	ClinGen ExAC gnomAD
CA6435084 rs777168606	364	T>S		No	ClinGen ExAC gnomAD
rs772745031 CA6435085	365	K>R		No	ClinGen ExAC gnomAD
rs1592029728 CA383815782	366	L>P		No	ClinGen Ensembl
CA383815814 rs1565430782	369	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1592029826 CA383815878	374	N>T		No	ClinGen Ensembl
rs747431632 CA6435087	377	L>V		No	ClinGen ExAC gnomAD
CA383815929 rs1209362827	378	A>D		No	ClinGen TOPMed
rs1256475233 CA383815924	378	A>T		No	ClinGen gnomAD
CA6435089 rs371604377	379	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1210965408 CA383815953	380	E>*		No	ClinGen TOPMed
CA383815971 rs1179128070	381	I>T		No	ClinGen TOPMed gnomAD
rs1293002574 CA383816010	385	V>M		No	ClinGen TOPMed

No associated diseases with Q9ULI2

2 regional properties for Q9ULI2

Type	Name	Position	InterPro Accession
domain	ATP-grasp fold	119 - 304	IPR011761
domain	ATP-grasp fold, RimK-type	114 - 302	IPR013651

Functions

		Description
EC Number	6.3.1.17	Acid--ammonia (or amine) ligases (amide synthases)
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
citrate-L-glutamate ligase activity	Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate.
ligase activity, forming carbon-nitrogen bonds	Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
metal ion binding	Binding to a metal ion.
N-acetyl-L-aspartate-L-glutamate ligase activity	Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate.

2 GO annotations of biological process

Name	Definition
glutamine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VCE9	RIMKLB	Beta-citrylglutamate synthase B	Bos taurus (Bovine)	PR
Q8IXN7	RIMKLA	N-acetylaspartylglutamate synthase A	Homo sapiens (Human)	PR
Q6PFX8	Rimkla	N-acetylaspartylglutamate synthase A	Mus musculus (Mouse)	PR
Q80WS1	Rimklb	Beta-citrylglutamate synthase B	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MCSSVAAKLW	FLTDRRIRED	YPQKEILRAL	KAKCCEEELD	FRAVVMDEVV	LTIEQGNLGL
70	80	90	100	110	120
RINGELITAY	PQVVVVRVPT	PWVQSDSDIT	VLRHLEKMGC	RLMNRPQAIL	NCVNKFWTFQ
130	140	150	160	170	180
ELAGHGVPLP	DTFSYGGHEN	FAKMIDEAEV	LEFPMVVKNT	RGHRGKAVFL	ARDKHHLADL
190	200	210	220	230	240
SHLIRHEAPY	LFQKYVKESH	GRDVRVIVVG	GRVVGTMLRC	STDGRMQSNC	SLGGVGMMCS
250	260	270	280	290	300
LSEQGKQLAI	QVSNILGMDV	CGIDLLMKDD	GSFCVCEANA	NVGFIAFDKA	CNLDVAGIIA
310	320	330	340	350	360
DYAASLLPSG	RLTRRMSLLS	VVSTASETSE	PELGPPASTA	VDNMSASSSS	VDSDPESTER
370	380
ELLTKLPGGL	FNMNQLLANE	IKLLVD