Q0VCE9
Gene name |
RIMKLB (FAM80B) |
Protein name |
Beta-citrylglutamate synthase B |
Names |
N-acetyl-aspartylglutamate synthetase B, NAAG synthetase B, NAAGS, Ribosomal protein S6 modification-like protein B |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:538579 |
EC number |
6.3.1.17: Acid--ammonia (or amine) ligases (amide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0VCE9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0VCE9-F1 | Predicted | AlphaFoldDB |
43 variants for Q0VCE9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs445195022 | 78 | V>E | No | EVA | |
| rs479899949 | 82 | W>S | No | EVA | |
| rs470528934 | 86 | D>V | No | EVA | |
| rs435852526 | 86 | D>Y | No | EVA | |
| rs478220680 | 102 | L>M | No | EVA | |
| rs442715199 | 116 | F>I | No | EVA | |
| rs447299411 | 125 | H>P | No | EVA | |
| rs478539577 | 126 | G>C | No | EVA | |
| rs435201128 | 197 | K>* | No | EVA | |
| rs482487041 | 235 | V>G | No | EVA | |
| rs459244629 | 238 | M>R | No | EVA | |
| rs445416195 | 239 | C>F | No | EVA | |
| rs459995347 | 244 | Q>L | No | EVA | |
| rs442470510 | 246 | K>T | No | EVA | |
| rs463149091 | 262 | G>V | No | EVA | |
| rs443190545 | 264 | D>E | No | EVA | |
| rs471472078 | 289 | K>Q | No | EVA | |
| rs451487928 | 289 | K>T | No | EVA | |
| rs472359613 | 292 | N>K | No | EVA | |
| rs434727971 | 292 | N>S | No | EVA | |
| rs455556848 | 313 | T>P | No | EVA | |
| rs467914549 | 326 | S>G | No | EVA | |
| rs467914549 | 326 | S>R | No | EVA | |
| rs450872054 | 326 | S>R | No | EVA | |
| rs443851201 | 327 | E>Q | No | EVA | |
| rs465405667 | 335 | P>R | No | EVA | |
| rs109424039 | 336 | Q>P | No | EVA | |
| rs459878210 | 344 | M>I | No | EVA | |
| rs449481049 | 345 | S>T | No | EVA | |
| rs480329497 | 346 | A>G | No | EVA | |
| rs463296735 | 348 | S>A | No | EVA | |
| rs471209362 | 349 | S>R | No | EVA | |
| rs457606969 | 356 | E>* | No | EVA | |
| rs441077608 | 358 | T>P | No | EVA | |
| rs472552592 | 359 | E>D | No | EVA | |
| rs455422316 | 362 | L>M | No | EVA | |
| rs435377858 | 365 | K>T | No | EVA | |
| rs457419313 | 368 | G>W | No | EVA | |
| rs465340387 | 373 | M>I | No | EVA | |
| rs437339443 | 373 | M>R | No | EVA | |
| rs445260055 | 376 | L>R | No | EVA | |
| rs449355581 | 382 | K>N | No | EVA | |
| rs480843700 | 387 | E>G | No | EVA |
No associated diseases with Q0VCE9
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.1.17 | Acid--ammonia (or amine) ligases (amide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| citrate-L-glutamate ligase activity | Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| metal ion binding | Binding to a metal ion. |
| N-acetyl-L-aspartate-L-glutamate ligase activity | Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IXN7 | RIMKLA | N-acetylaspartylglutamate synthase A | Homo sapiens (Human) | PR |
| Q9ULI2 | RIMKLB | Beta-citrylglutamate synthase B | Homo sapiens (Human) | PR |
| Q6PFX8 | Rimkla | N-acetylaspartylglutamate synthase A | Mus musculus (Mouse) | PR |
| Q80WS1 | Rimklb | Beta-citrylglutamate synthase B | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCSSVAAKLW | FLTDRRIRED | YPQKEILRAL | KAKCCEEELD | FRAVVMDELV | LTVEQGNLGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RINGELITAY | PQVVVVRVPT | PWVQSDSDIT | VLRHLEKMGC | RLMNRPQAIL | NCVNKFWTFQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELAGHGVPLP | DTFSYGGHEN | FAKMIDEAEV | LEFPMVVKNT | RGHRGKAVFL | ARDKHHLADL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SHLIRHEAPY | LFQKYVKESH | GRDVRVIVVG | GRVVGTMLRC | STDGRMQSNC | SLGGVGMMCS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSEQGKQLAI | QVSNILGMDV | CGIDLLMKDD | GSFCVCEANA | NVGFIAFDKA | CNLDVAGIIA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYAASLLPSG | RLTRRMSLLS | VVSTASETSE | PELGPQANTA | VDNMSASSSS | VDSDPETTER |
| 370 | 380 | ||||
| ELLTKLPGGL | FNMNQLLANE | IKLLVE |