Q80WS1
Gene name |
Rimklb (Fam80b, Kiaa1238) |
Protein name |
Beta-citrylglutamate synthase B |
Names |
N-acetyl-aspartylglutamate synthetase B, NAAG synthetase B, NAAGS, Ribosomal protein S6 modification-like protein B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:108653 |
EC number |
6.3.1.17: Acid--ammonia (or amine) ligases (amide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80WS1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80WS1-F1 | Predicted | AlphaFoldDB |
20 variants for Q80WS1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs236747424 | 63 | S>G | No | EVA | |
| rs3388860730 | 74 | V>M | No | EVA | |
| rs3388858093 | 97 | K>N | No | EVA | |
| rs3396507519 | 112 | C>* | No | EVA | |
| rs3397321177 | 112 | C>S | No | EVA | |
| rs3397268385 | 112 | C>S | No | EVA | |
| rs3388851531 | 114 | N>I | No | EVA | |
| rs3388821558 | 116 | F>L | No | EVA | |
| rs3388852429 | 123 | A>S | No | EVA | |
| rs249422125 | 178 | A>S | No | EVA | |
| rs3388847316 | 209 | V>E | No | EVA | |
| rs3388858934 | 220 | C>Y | No | EVA | |
| rs3388858990 | 223 | D>Y | No | EVA | |
| rs264251152 | 238 | M>L | No | EVA | |
| rs3397457334 | 283 | G>D | No | EVA | |
| rs3397321149 | 284 | F>Y | No | EVA | |
| rs3397303320 | 285 | I>N | No | EVA | |
| rs228946578 | 339 | A>T | No | EVA | |
| rs261357872 | 340 | A>V | No | EVA | |
| rs3388836425 | 361 | R>* | No | EVA |
No associated diseases with Q80WS1
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.1.17 | Acid--ammonia (or amine) ligases (amide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| citrate-L-glutamate ligase activity | Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
| metal ion binding | Binding to a metal ion. |
| N-acetyl-L-aspartate-L-glutamate ligase activity | Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VCE9 | RIMKLB | Beta-citrylglutamate synthase B | Bos taurus (Bovine) | PR |
| Q8IXN7 | RIMKLA | N-acetylaspartylglutamate synthase A | Homo sapiens (Human) | PR |
| Q9ULI2 | RIMKLB | Beta-citrylglutamate synthase B | Homo sapiens (Human) | PR |
| Q6PFX8 | Rimkla | N-acetylaspartylglutamate synthase A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MCSSVTGKLW | FLTDRRIRED | YPQKEILRAL | KAKCCEEELD | FRAVVMDEMV | LTVEQGNLGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RISGELISAY | PQVVVVRVPT | PWVQSDSDIT | VLRHLEKMGC | RLMNRPQAIL | NCVNKFWTFQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ELAGHGVPLP | DTFSYGGHEN | FAKMIDEAEV | LEFPMVVKNT | RGHRGKAVFL | ARDKHHLADL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SHLIRHEAPY | LFQKYIKESH | GRDVRVIVVG | GRVVGTMLRC | STDGRMQSNC | SLGGVGMMCS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSEQGKQLAI | QVSNILGTDV | CGIDLLMKDD | GSFCVCEANA | NVGFIAFDKA | CNLDVAGIIA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYAASLLPAG | RLTRRMSLLS | VVSTASETSE | PELGPPASAA | VDNMSASSSS | VDSDPESTTE |
| 370 | 380 | ||||
| REMLTKLPGG | LFNMNQLLAN | EIKLLVE |