AiPD: Autoinhibited Protein Database

Q9UJZ1

Gene name	STOML2 (SLP2, HSPC108)
Protein name	Stomatin-like protein 2, mitochondrial
Names	SLP-2, EPB72-like protein 2, Paraprotein target 7, Paratarg-7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:30968
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-356 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

270-356 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UJZ1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UJZ1-F1	Predicted				AlphaFoldDB

231 variants for Q9UJZ1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs369859096 CA373337598	2	L>M		No	ClinGen ESP TOPMed gnomAD
rs1370037540 CA373337594	2	L>P		No	ClinGen gnomAD
CA192725950 rs369859096	2	L>V		No	ClinGen ESP TOPMed gnomAD
rs752036887 CA5041376	3	A>E		No	ClinGen ExAC gnomAD
rs553229212 CA192725941	3	A>S		No	ClinGen ExAC gnomAD
CA5041377 rs553229212	3	A>T		No	ClinGen ExAC gnomAD
rs750689070 CA5041373	5	A>V		No	ClinGen ExAC TOPMed gnomAD
CA192725907 rs894735369	6	A>G		No	ClinGen TOPMed
rs1207768511 CA373337548	6	A>T		No	ClinGen gnomAD
CA5041372 rs765510581	7	R>Q		No	ClinGen ExAC gnomAD
rs1564009325 CA373337532	7	R>W		No	ClinGen Ensembl
rs1245944656 CA373337519	8	G>C		No	ClinGen gnomAD
CA5041371 rs761928176	8	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1245944656 CA373337522	8	G>S		No	ClinGen gnomAD
rs764054190 CA5041369	9	T>I		No	ClinGen ExAC gnomAD
rs1322962385 CA373337489	10	G>A		No	ClinGen gnomAD
rs1366111450 CA373337494	10	G>R		No	ClinGen gnomAD
rs1322962385 CA373337487	10	G>V		No	ClinGen gnomAD
CA5041367 rs775593796	11	A>S		No	ClinGen ExAC gnomAD
rs951174460 CA192725853	11	A>V		No	ClinGen gnomAD
CA373337444 rs1265525934	14	L>R		No	ClinGen gnomAD
rs772065647 CA5041366	15	R>K		No	ClinGen ExAC gnomAD
CA5041340 rs776107111	17	S>C		No	ClinGen ExAC TOPMed gnomAD
CA373337222 rs1393179255	20	A>S		No	ClinGen TOPMed
CA5041337 rs779388359	21	S>F		No	ClinGen ExAC gnomAD
CA5041336 rs757587298	22	G>C		No	ClinGen ExAC gnomAD
CA373337154 rs1332129334	23	R>C		No	ClinGen gnomAD
rs1416031553 CA373337144	23	R>P		No	ClinGen TOPMed gnomAD
CA5041333 rs778151483	24	A>G		No	ClinGen ExAC gnomAD
CA373337133 rs749627477	24	A>P		No	ClinGen ExAC gnomAD
CA5041334 rs749627477	24	A>T		No	ClinGen ExAC gnomAD
CA5041332 rs756389373	27	R>H		No	ClinGen ExAC TOPMed gnomAD
rs756389373 CA373336998	27	R>P		No	ClinGen ExAC TOPMed gnomAD
CA373336970 rs1294294803	28	A>V		No	ClinGen TOPMed
CA192725512 rs71521253	29	S>F		No	ClinGen Ensembl
TCGA novel	34	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145420701 CA5041331	34	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1237198318 CA373336743	36	T>S		No	ClinGen TOPMed gnomAD
CA373336715 rs1263884907	37	V>A		No	ClinGen gnomAD
CA373336728 rs1444623790	37	V>M		No	ClinGen gnomAD
rs762661515 CA5041326	40	F>L		No	ClinGen ExAC gnomAD
rs1478062823 CA373336580	41	V>L		No	ClinGen gnomAD
rs1282205878 CA373336530	42	P>R		No	ClinGen gnomAD
CA373336539 rs1564009051	42	P>S		No	ClinGen Ensembl
rs1450193620 CA373336496	43	Q>H		No	ClinGen gnomAD
rs1436015727 CA373336400	47	W>R		No	ClinGen TOPMed
rs747531882 CA192725467	49	V>A		No	ClinGen Ensembl
rs910094247 CA192725466	51	R>G		No	ClinGen Ensembl
CA373336270 rs983811316	51	R>P		No	ClinGen gnomAD
CA192725453 rs983811316	51	R>Q		No	ClinGen gnomAD
CA192725452 rs951118441	53	G>S		No	ClinGen Ensembl
rs1455212823 CA373336185	55	F>C		No	ClinGen gnomAD
CA5041322 rs761452134	57	R>G		No	ClinGen ExAC gnomAD
CA373336155 rs1159451078	57	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA192725433 rs1025427751	58	I>V		No	ClinGen Ensembl
CA373336092 rs1258028440	60	E>K		No	ClinGen TOPMed
CA192725040 rs1005042027	62	G>S		No	ClinGen TOPMed
CA5041302 rs763766258	65	I>L		No	ClinGen ExAC gnomAD
rs760111495 CA5041301	68	P>L		No	ClinGen ExAC gnomAD
rs1226169851 CA373335655	68	P>S		No	ClinGen gnomAD
CA373335581 rs1295721462	71	D>N		No	ClinGen gnomAD
rs763483882 CA5041298	72	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	73	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5041297 rs773757788	73	I>V		No	ClinGen ExAC gnomAD
rs1366649135 CA373335510	74	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA373335498 rs1168336946	75	Y>H		No	ClinGen gnomAD
CA192724956 rs368615584	78	S>N		No	ClinGen ESP TOPMed
rs1428434116 CA373335370	79	L>F		No	ClinGen gnomAD
rs1415149829 CA373335284	82	I>S		No	ClinGen TOPMed
CA373335300 rs1392606736	82	I>V		No	ClinGen gnomAD
CA373335243 rs1564008625	84	I>F		No	ClinGen Ensembl
CA5041294 rs781568932	86	V>M		No	ClinGen ExAC TOPMed gnomAD
CA373335130 rs1490571305	88	E>Q		No	ClinGen TOPMed gnomAD
rs768863648 CA5041293	89	Q>H		No	ClinGen ExAC gnomAD
rs374236012 CA373335006	90	S>*		No	ClinGen ESP ExAC gnomAD
rs374236012 CA5041292	90	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs374236012 CA373335001	90	S>W		No	ClinGen ESP ExAC gnomAD
rs371826848 CA192724918	94	L>P		No	ClinGen ESP TOPMed
rs1274513770 CA373334917	94	L>V		No	ClinGen TOPMed
rs750341682 CA5041289	95	D>N		No	ClinGen ExAC gnomAD
rs768827289 CA5041275	101	I>L		No	ClinGen ExAC TOPMed gnomAD
CA5041272 rs772218681	102	D>E		No	ClinGen ExAC gnomAD
CA5041273 rs775482860	102	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1396009855 CA373334516	106	Y>H		No	ClinGen gnomAD
CA373334485 rs1484990298	107	L>Q		No	ClinGen TOPMed
CA5041271 rs745910436	108	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5041270 COSM1674470 rs11548407	112	P>S	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA373334281 rs1157221791	114	K>E		No	ClinGen TOPMed gnomAD
rs749144448 CA5041268	114	K>R		No	ClinGen ExAC gnomAD
CA373333955 rs1323148887	118	G>D		No	ClinGen gnomAD
COSM170968 CA5041244 rs764083315	118	G>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1367283690 CA373333922	119	V>L		No	ClinGen gnomAD
CA373333860 rs1256115638	121	D>N		No	ClinGen TOPMed
CA373333832 rs1303515067	122	P>L		No	ClinGen gnomAD
CA192724545 rs780464977	122	P>S		No	ClinGen Ensembl
CA5041238 rs767788822	126	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
VAR_026830 CA192724517 rs17856326	129	L>P		No	ClinGen UniProt Ensembl dbSNP
rs769559265 CA5041232	139	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748033074 CA5041231	140	K>R		No	ClinGen ExAC TOPMed gnomAD
CA5041230 rs201404939	141	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs768464398 CA5041229	141	L>H		No	ClinGen ExAC gnomAD
rs201404939 CA373333516	141	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA5041228 rs775594555	142	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1202603054 CA373333506	142	S>P		No	ClinGen gnomAD
rs775594555 CA373333498	142	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1564008198	143	L>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA373333474 rs1471468153	144	D>G		No	ClinGen TOPMed
rs749838828 CA5041225	148	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5041226 rs200523791	148	R>W		No	ClinGen ExAC TOPMed gnomAD
CA373333312 rs1332061709	150	R>Q		No	ClinGen TOPMed gnomAD
CA5041213 rs761625496	150	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5041211 rs768596460	151	E>D		No	ClinGen ExAC gnomAD
CA5041212 rs776617508	151	E>G		No	ClinGen ExAC gnomAD
TCGA novel	151	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373333276 rs1451952562	152	S>C		No	ClinGen gnomAD
rs1406306765 CA373333227	155	A>V		No	ClinGen gnomAD
CA373333222 rs1587190983	156	S>G		No	ClinGen Ensembl
rs1470694254 CA373333217	156	S>N		No	ClinGen gnomAD
CA192724206 rs994783784 COSM1674469	157	I>T	ovary [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1182224075 CA373333187	158	V>G		No	ClinGen TOPMed gnomAD
CA373333193 rs1237435309	158	V>M		No	ClinGen gnomAD
CA373333162 rs1564008076	160	A>S		No	ClinGen Ensembl
rs1587190926 CA373333123	162	N>T		No	ClinGen Ensembl
rs1388887300 CA373333094	163	Q>H		No	ClinGen TOPMed
rs763851657 CA192724205	163	Q>K		No	ClinGen Ensembl
CA5041207 rs745445672	166	D>N		No	ClinGen ExAC gnomAD
CA5041205 rs756688976	169	G>V		No	ClinGen ExAC gnomAD
COSM273312 rs753222022 CA5041204	171	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs781632715 CA5041203	171	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5041201 rs751862270	173	L>H		No	ClinGen ExAC gnomAD
rs1313882943 CA373332846 COSM1108609	174	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA373332844 rs1377638110	174	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1382962039 CA373332773	177	I>N		No	ClinGen gnomAD
CA373332684 rs1333716602	181	H>Y		No	ClinGen TOPMed
CA373332589 rs1346632260	185	R>G		No	ClinGen TOPMed gnomAD
rs1057412414 CA192724117	185	R>Q		No	ClinGen Ensembl
rs1346632260 CA373332586	185	R>W		No	ClinGen TOPMed gnomAD
CA5041197 rs750556216	188	E>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	189	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1446958099 COSM1108608 CA373332418	192	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs937866355 CA192724090	192	M>T		No	ClinGen TOPMed gnomAD
CA373332234 rs1273850773	194	V>G		No	ClinGen gnomAD
rs1564007895 CA373332161	197	E>Q		No	ClinGen Ensembl
CA373332138 rs1462012633	198	R>Q		No	ClinGen TOPMed
rs985870303 CA192723812	198	R>W		No	ClinGen TOPMed gnomAD
rs138647485 CA5041175	199	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA192723811 rs138647485	199	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5041176 rs376565687	199	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA373332029 rs1407171605	201	R>Q		No	ClinGen gnomAD
CA5041174 rs144686869	201	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA5041173 rs753914419	202	A>D		No	ClinGen ExAC gnomAD
rs764188592 CA5041172	203	T>I		No	ClinGen ExAC
rs1356404935 CA373331788	209	G>E		No	ClinGen gnomAD
CA5041170 rs527475475	213	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA373331657 rs142495898	215	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1327985691 CA373331668	215	I>N		No	ClinGen TOPMed
CA373331670 rs1326028757	215	I>V		No	ClinGen gnomAD
rs770556916 CA5041167	216	N>I		No	ClinGen ExAC TOPMed gnomAD
rs770556916 CA5041166	216	N>S		No	ClinGen ExAC TOPMed gnomAD
CA373331564 rs1194065746 COSM1227907	220	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	224	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5041164 rs772703192	225	Q>K		No	ClinGen ExAC TOPMed
rs1035876812 CA192723783	225	Q>R		No	ClinGen Ensembl
CA5041163 rs370992440	228	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA373331356 COSM1108606 rs1320732098	230	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5041160 rs758721676	234	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5041161 rs758721676	234	A>T		No	ClinGen ExAC TOPMed gnomAD
CA373330384 rs1223674773	235	E>K		No	ClinGen gnomAD
CA373330356 rs1306717766	236	Q>K		No	ClinGen gnomAD
TCGA novel	238	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1475635497 CA373330247	241	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs769316607 CA5041145	247	V>I		No	ClinGen ExAC TOPMed
rs761273149 CA5041144	248	L>V		No	ClinGen ExAC TOPMed gnomAD
rs377443648 CA192723632	249	A>V		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs772575616 CA5041142	250	K>*		No	ClinGen ExAC gnomAD
rs1171167508 CA373329963	250	K>N		No	ClinGen TOPMed
rs1053304196 CA192723612	252	K>N		No	ClinGen TOPMed gnomAD
rs1390739688 CA373329927	252	K>R		No	ClinGen TOPMed
CA373329851 rs1455162008	255	A>V		No	ClinGen gnomAD
rs201944176 COSM277510 CA5041139	259	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA373329682 rs1376408227	264	A>S		No	ClinGen TOPMed
rs1564007621 CA373329636	266	T>I		No	ClinGen Ensembl
rs752761742 CA5041136	268	H>D		No	ClinGen ExAC gnomAD
rs781046341 CA5041134	268	H>P		No	ClinGen ExAC gnomAD
CA5041135 rs752761742	268	H>Y		No	ClinGen ExAC gnomAD
CA192723233 rs901606189	272	A>G		No	ClinGen gnomAD
CA373329330 rs1333943331	272	A>T		No	ClinGen TOPMed gnomAD
rs901606189 CA373329321	272	A>V		No	ClinGen gnomAD
CA373329201 rs1470743758	280	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs36064663 CA5041087	283	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1173491392 CA373329111	284	S>G		No	ClinGen gnomAD
rs1223657497 CA373329059	285	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs752235609 CA5041085	285	A>V		No	ClinGen ExAC gnomAD
TCGA novel	291	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373328865 rs1263950434	292	D>E		No	ClinGen gnomAD
rs930593352 CA192723179	292	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs930593352 CA373328877	292	D>Y		No	ClinGen gnomAD
CA5041080 rs762017957	294	N>S		No	ClinGen ExAC gnomAD
TCGA novel	296	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1442826006 CA373328778	296	I>V		No	ClinGen gnomAD
rs1479971283 CA373328711	299	P>S		No	ClinGen TOPMed
CA5041079 rs776942973	301	N>S		No	ClinGen ExAC gnomAD
rs531481768 CA5041078	302	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs919137231 CA192723143	303	G>A		No	ClinGen TOPMed
rs775514731 CA5041076	304	D>N		No	ClinGen ExAC TOPMed gnomAD
rs552229756 CA5041074	305	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1248932914 CA373328507	309	V>M		No	ClinGen gnomAD
CA373328497 rs185345893	310	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA5041073 rs185345893	310	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA373328490 rs1407636521	310	A>V		No	ClinGen TOPMed
CA5041058 rs772150100	315	V>I		No	ClinGen ExAC gnomAD
rs774372458 CA5041056	318	A>V		No	ClinGen ExAC
rs368708176 CA5041052	323	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5041053 rs368708176	323	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs747817459 CA5041051	325	P>A		No	ClinGen ExAC gnomAD
rs1276517125 CA373328140	329	D>Y		No	ClinGen gnomAD
CA5041050 rs756945705	330	S>L		No	ClinGen ExAC TOPMed gnomAD
CA5041049 rs754567463	331	L>F		No	ClinGen ExAC gnomAD
rs148822028 CA5041048	331	L>R		No	ClinGen ESP ExAC gnomAD
CA373328051 rs1375509536	333	S>G		No	ClinGen TOPMed gnomAD
rs779522338 CA5041047	333	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1350586867 CA373327931	338	D>V		No	ClinGen TOPMed gnomAD
CA5041045 rs754293010	339	V>I		No	ClinGen ExAC gnomAD
rs764351078 CA5041044	341	G>D		No	ClinGen ExAC gnomAD
rs1466885292 CA373327859	342	T>A		No	ClinGen gnomAD
CA192722562 rs552266845	347	D>N		No	ClinGen 1000Genomes TOPMed gnomAD
rs977632254 CA192722556	350	L>F		No	ClinGen Ensembl
CA373327639 rs1480026526	352	R>*		No	ClinGen TOPMed gnomAD
COSM170353 CA5041041 rs767682475	352	R>Q	large_intestine Variant assessed as Somatic; 9.241e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs759666265 CA5041040	354	K>R		No	ClinGen ExAC TOPMed gnomAD
CA5041039 rs192027986	355	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with Q9UJZ1

2 regional properties for Q9UJZ1

Type	Name	Position	InterPro Accession
domain	Band 7 domain	36 - 209	IPR001107
domain	STML2-like, C-terminal extension	260 - 320	IPR032435

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Peripheral membrane protein Mitochondrion Mitochondrion inner membrane ; Lipid-anchor Mitochondrion intermembrane space Membrane raft Cytoplasm, cytoskeleton	Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876) Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:10713127, PubMed:18641330) A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
extrinsic component of plasma membrane	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space	The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
cardiolipin binding	Binding to cardiolipin.
GTPase binding	Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

14 GO annotations of biological process

Name	Definition
CD4-positive, alpha-beta T cell activation	The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
lipid localization	Any process in which a lipid is transported to, or maintained in, a specific location.
mitochondrial calcium ion transmembrane transport	The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial protein processing	The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
mitochondrion organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
positive regulation of cardiolipin metabolic process	Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process.
positive regulation of interleukin-2 production	Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of mitochondrial DNA replication	Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.
positive regulation of mitochondrial membrane potential	Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
protein complex oligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
proton motive force-driven mitochondrial ATP synthesis	The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.
stress-induced mitochondrial fusion	Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis.
T cell receptor signaling pathway	The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q32LL2	STOML2	Stomatin-like protein 2, mitochondrial	Bos taurus (Bovine)	PR
P0ABC7	hflK	Modulator of FtsH protease HflK	Escherichia coli (strain K12)	PR
Q4FZT0	Stoml2	Stomatin-like protein 2, mitochondrial	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MLARAARGTG	ALLLRGSLLA	SGRAPRRASS	GLPRNTVVLF	VPQQEAWVVE	RMGRFHRILE
70	80	90	100	110	120
PGLNILIPVL	DRIRYVQSLK	EIVINVPEQS	AVTLDNVTLQ	IDGVLYLRIM	DPYKASYGVE
130	140	150	160	170	180
DPEYAVTQLA	QTTMRSELGK	LSLDKVFRER	ESLNASIVDA	INQAADCWGI	RCLRYEIKDI
190	200	210	220	230	240
HVPPRVKESM	QMQVEAERRK	RATVLESEGT	RESAINVAEG	KKQAQILASE	AEKAEQINQA
250	260	270	280	290	300
AGEASAVLAK	AKAKAEAIRI	LAAALTQHNG	DAAASLTVAE	QYVSAFSKLA	KDSNTILLPS
310	320	330	340	350
NPGDVTSMVA	QAMGVYGALT	KAPVPGTPDS	LSSGSSRDVQ	GTDASLDEEL	DRVKMS