P0ABC7

PR
Gene name
hflK (hflA, b4174, JW4132)
Protein name
Modulator of FtsH protease HflK
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b4174
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P0ABC7

Entry ID Method Resolution Chain Position Source
7VHP EM 327 A E/F/N/O/S/U/g/h/i/j/q/r 1-419 PDB
7VHQ EM 327 A E/F/U 79-345 PDB
7WI3 EM 400 A B/F/G/N/R/S/a/b/i/j/k/l 1-419 PDB
AF-P0ABC7-F1 Predicted AlphaFoldDB

No variants for P0ABC7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0ABC7

No associated diseases with P0ABC7

10 regional properties for P0ABC7

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 52 - 84 IPR003107-1
repeat HAT (Half-A-TPR) repeat 96 - 128 IPR003107-2
repeat HAT (Half-A-TPR) repeat 130 - 164 IPR003107-3
repeat HAT (Half-A-TPR) repeat 280 - 315 IPR003107-4
repeat HAT (Half-A-TPR) repeat 383 - 421 IPR003107-5
repeat HAT (Half-A-TPR) repeat 423 - 459 IPR003107-6
repeat HAT (Half-A-TPR) repeat 547 - 581 IPR003107-7
repeat HAT (Half-A-TPR) repeat 584 - 618 IPR003107-8
repeat HAT (Half-A-TPR) repeat 656 - 690 IPR003107-9
repeat HAT (Half-A-TPR) repeat 692 - 726 IPR003107-10

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of external side of plasma membrane The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasma membrane protein complex Any protein complex that is part of the plasma membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
negative regulation of peptidase activity Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UJZ1 STOML2 Stomatin-like protein 2, mitochondrial Homo sapiens (Human) PR
Q4FZT0 Stoml2 Stomatin-like protein 2, mitochondrial Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAWNQPGNNG QDRDPWGSSK PGGNSEGNGN KGGRDQGPPD LDDIFRKLSK KLGGLGGGKG
70 80 90 100 110 120
TGSGGGSSSQ GPRPQLGGRV VTIAAAAIVI IWAASGFYTI KEAERGVVTR FGKFSHLVEP
130 140 150 160 170 180
GLNWKPTFID EVKPVNVEAV RELAASGVML TSDENVVRVE MNVQYRVTNP EKYLYSVTSP
190 200 210 220 230 240
DDSLRQATDS ALRGVIGKYT MDRILTEGRT VIRSDTQREL EETIRPYDMG ITLLDVNFQA
250 260 270 280 290 300
ARPPEEVKAA FDDAIAAREN EQQYIREAEA YTNEVQPRAN GQAQRILEEA RAYKAQTILE
310 320 330 340 350 360
AQGEVARFAK LLPEYKAAPE ITRERLYIET MEKVLGNTRK VLVNDKGGNL MVLPLDQMLK
370 380 390 400 410
GGNAPAAKSD NGASNLLRLP PASSSTTSGA SNTSSTSQGD IMDQRRANAQ RNDYQRQGE