AiPD: Autoinhibited Protein Database

Q9UIV1

Gene name	CNOT7 (CAF1)
Protein name	CCR4-NOT transcription complex subunit 7
Names	BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a
Species	Homo sapiens (Human)
KEGG Pathway	hsa:29883
EC number	3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

181-285 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

181-285 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q9UIV1

Entry ID	Method	Resolution	Chain	Position	Source
2D5R	X-ray	250 A	A	11-262	PDB
4GMJ	X-ray	270 A	B/D/F	1-285	PDB
7AX1	X-ray	330 A	B	2-285	PDB
7VOI	X-ray	438 A	B	1-285	PDB
AF-Q9UIV1-F1	Predicted				AlphaFoldDB

128 variants for Q9UIV1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA4643051 rs767567772	3	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4643049 rs751586478	5	T>A		No	ClinGen ExAC gnomAD
rs766330962 CA4643048	5	T>I		No	ClinGen ExAC TOPMed gnomAD
CA370403126 rs766330962	5	T>S		No	ClinGen ExAC TOPMed gnomAD
CA370403115 rs1334555593	7	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM1496863 CA4643047 rs762916263	9	S>R	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA370403096 rs1563214981	9	S>T		No	ClinGen Ensembl
rs1405230418 CA370403090	10	Q>E		No	ClinGen gnomAD
rs1358368834 CA370403067	11	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	11	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA172947177 rs970479963	13	C>R		No	ClinGen TOPMed
CA370402990 rs1418125981	17	A>G		No	ClinGen gnomAD
CA172947174 rs930242144	17	A>S		No	ClinGen gnomAD
CA4643044 rs142912321	19	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs142912321 CA370402965	19	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4643042 rs768140191	21	D>G		No	ClinGen ExAC gnomAD
CA4643043 rs776354768	21	D>H		No	ClinGen ExAC gnomAD
CA370402933 rs1198098277	22	E>K		No	ClinGen gnomAD
CA4643038 rs200983574	24	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4643040 rs369445114	24	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4643039 rs369445114	24	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA370402890 rs1487779225	25	K>E		No	ClinGen gnomAD
rs1219452358 CA370402880	25	K>N		No	ClinGen TOPMed
CA4643037 rs778137902	28	R>H		No	ClinGen ExAC TOPMed gnomAD
CA370402837 rs1201029345	29	Q>K		No	ClinGen TOPMed
rs375278542 COSM2873028 CA4643036	32	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs781083959 CA4643035	34	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	35	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148569654 CA4643034	37	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	40	D>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1188071244 CA370402430	48	A>V		No	ClinGen TOPMed
rs1178806345 CA370402409	51	I>T		No	ClinGen gnomAD
CA4642997 rs367872876	61	Q>R		No	ClinGen ESP ExAC
TCGA novel	76	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA172946180 rs370779310	79	L>V		No	ClinGen gnomAD
rs778900473 CA4642991	80	T>I		No	ClinGen ExAC gnomAD
CA4642990 rs757339677	82	M>V		No	ClinGen ExAC gnomAD
rs753778888 CA4642989	83	N>H		No	ClinGen ExAC gnomAD
CA370402179 rs1315840022	84	E>G		No	ClinGen gnomAD
CA4642988 rs777784414	85	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA4642987 rs755985486	86	G>A		No	ClinGen ExAC
CA4642986 rs188113569	87	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767309108 CA4642985	87	E>V		No	ClinGen ExAC
CA4642984 rs754622526	88	Y>H		No	ClinGen ExAC gnomAD
rs1446456914 CA370402144	89	P>L		No	ClinGen gnomAD
CA370402138 rs1406070868	90	P>L		No	ClinGen gnomAD
CA370402133 rs1267476160	91	G>A		No	ClinGen TOPMed gnomAD
rs762517857 CA370401967	104	T>K		No	ClinGen ExAC gnomAD
CA4642981 rs762517857	104	T>M		No	ClinGen ExAC gnomAD
rs201352145 CA172936521	105	E>K		No	ClinGen 1000Genomes
rs764621462 CA4642955	107	M>T		No	ClinGen ExAC gnomAD
CA370401045 rs1563198871	113	I>V		No	ClinGen Ensembl
TCGA novel	114	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370400984 rs759942846	122	Q>H		No	ClinGen ExAC
rs1294944378 CA370400963	125	K>T		No	ClinGen TOPMed gnomAD
rs774447300 CA4642950	126	H>L		No	ClinGen ExAC gnomAD
rs915272393 CA172936508	126	H>Q		No	ClinGen TOPMed gnomAD
TCGA novel	126	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4642948 rs749409263	128	E>D		No	ClinGen ExAC TOPMed gnomAD
rs773648799 CA172936499	129	E>G		No	ClinGen Ensembl
CA4642946 rs769967825	131	I>V		No	ClinGen ExAC gnomAD
rs781268765 CA370400913	132	E>D		No	ClinGen ExAC TOPMed gnomAD
rs748150992 CA4642945	132	E>K		No	ClinGen ExAC gnomAD
rs1198764115 CA370400904	134	Q>*		No	ClinGen TOPMed
CA370400899 rs1199498530	134	Q>H		No	ClinGen gnomAD
rs768542225 CA172936482	135	Y>C		No	ClinGen Ensembl
CA370400895 rs1400074762	135	Y>D		No	ClinGen gnomAD
CA172936476 rs17850178	142	T>I		No	ClinGen Ensembl
CA370400832 rs1473009991	144	G>A		No	ClinGen TOPMed
rs746944412 CA4642940	149	E>D		No	ClinGen ExAC TOPMed gnomAD
CA4642941 rs779598549	149	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1471513111 CA370400795	150	G>E		No	ClinGen TOPMed
rs1234630840 CA370400798	150	G>R		No	ClinGen gnomAD
rs1314283160 CA370400790	151	V>F		No	ClinGen gnomAD
rs548128564 CA4642939	152	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs766824900	158	S>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA4642909 rs562363899	159	G>S		No	ClinGen ExAC TOPMed gnomAD
rs79465220 CA172935046	163	G>C		No	ClinGen Ensembl
TCGA novel	164	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1257252552 CA370400505	166	I>V		No	ClinGen gnomAD
rs765495514 CA4642907	168	I>M		No	ClinGen ExAC gnomAD
CA4642906 rs759521873	169	L>V		No	ClinGen ExAC gnomAD
CA370400476 rs1476469058	170	T>I		No	ClinGen TOPMed
CA370400478 rs1476469058	170	T>N		No	ClinGen TOPMed
rs775280548 CA4642902	171	N>D		No	ClinGen ExAC gnomAD
CA370400464 rs1413135775	172	S>C		No	ClinGen TOPMed
rs1284844296 CA370400455	173	N>K		No	ClinGen gnomAD
TCGA novel	175	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771925219 CA4642901	175	P>S		No	ClinGen ExAC gnomAD
TCGA novel	178	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370400417 rs1422081084	179	L>V		No	ClinGen TOPMed
CA4642899 rs774008173	180	D>N		No	ClinGen ExAC
rs1314228146 CA370400404	181	F>L		No	ClinGen gnomAD
CA370400382 rs1199187510	183	E>D		No	ClinGen gnomAD
rs770529090 CA4642898	184	I>V		No	ClinGen ExAC gnomAD
rs1402157230 COSM1097454 CA370400365	186	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA370400336 rs1390932291	190	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA370400337 rs1390932291	190	P>R		No	ClinGen gnomAD
TCGA novel	192	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370400286 rs1554475435	197	Y>*		No	ClinGen Ensembl
CA4642895 rs755562076	200	K>R		No	ClinGen ExAC TOPMed gnomAD
rs780357311 CA4642893	206	K>R		No	ClinGen ExAC gnomAD
rs1346903614 CA370399886	207	G>D		No	ClinGen TOPMed
rs1214946785 CA370399816	213	A>S		No	ClinGen gnomAD
COSM750212 CA370399769 rs1453783166	217	E>Q	lung Variant assessed as Somatic; impact. central_nervous_system [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA370399721 rs1443002137	224	Q>R		No	ClinGen gnomAD
TCGA novel	226	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	228	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201539670 CA172933719	232	L>S		No	ClinGen 1000Genomes
CA172933713 rs181822276	239	F>I		No	ClinGen 1000Genomes
CA4642854 rs371008461	243	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1180209120 CA370399313	247	E>*		No	ClinGen gnomAD
CA370399276 rs1585772211	249	H>Q		No	ClinGen Ensembl
rs760199118 CA4642829	249	H>R		No	ClinGen ExAC gnomAD
CA4642828 rs775016646	252	D>G		No	ClinGen ExAC gnomAD
rs1382786685 CA370399204	257	G>A		No	ClinGen gnomAD
CA370399207 rs1339119719	257	G>R		No	ClinGen TOPMed gnomAD
CA370399206 rs1339119719	257	G>S		No	ClinGen TOPMed gnomAD
TCGA novel	258	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA370399199 rs1554473647	258	H>Y		No	ClinGen Ensembl
rs1334061263 CA370399183	260	Y>F		No	ClinGen TOPMed gnomAD
rs1393440071 CA370399185	260	Y>H		No	ClinGen gnomAD
rs1044327623 CA172932542	261	G>S		No	ClinGen Ensembl
TCGA novel	264	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4642824 rs770178762	266	S>L		No	ClinGen ExAC gnomAD
rs149444121 CA4642823	268	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA370399035 rs1161828066	282	N>S		No	ClinGen gnomAD
CA370399007 rs1419185662	286	S>G		No	ClinGen gnomAD

No associated diseases with Q9UIV1

No regional properties for Q9UIV1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9UIV1

Functions

		Description
EC Number	3.1.13.4	Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization	Nucleus Cytoplasm, P-body Cytoplasm, Cytoplasmic ribonucleoprotein granule	NANOS2 promotes its localization to P-body (By similarity) Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (PubMed:31439799)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
CCR4-NOT complex	The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.
CCR4-NOT core complex	The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

7 GO annotations of molecular function

Name	Definition
3'-5'-exoribonuclease activity	Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
exoribonuclease activity	Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
metal ion binding	Binding to a metal ion.
poly(A)-specific ribonuclease activity	Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
RNA binding	Binding to an RNA molecule or a portion thereof.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

18 GO annotations of biological process

Name	Definition
deadenylation-dependent decapping of nuclear-transcribed mRNA	Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
exonucleolytic catabolism of deadenylated mRNA	The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
gene silencing by RNA	A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
miRNA-mediated gene silencing	A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of type I interferon-mediated signaling pathway	Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway.
nuclear-transcribed mRNA poly(A) tail shortening	Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
P-body assembly	The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of mRNA catabolic process	Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of viral genome replication	Any process that activates or increases the frequency, rate or extent of viral genome replication.
regulation of tyrosine phosphorylation of STAT protein	Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3ZC01	CNOT7	CCR4-NOT transcription complex subunit 7	Bos taurus (Bovine)	PR
Q5ZJV9	CNOT7	CCR4-NOT transcription complex subunit 7	Gallus gallus (Chicken)	PR
Q60809	Cnot7	CCR4-NOT transcription complex subunit 7	Mus musculus (Mouse)	PR
A4II96	cnot7	CCR4-NOT transcription complex subunit 7	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MPAATVDHSQ	RICEVWACNL	DEEMKKIRQV	IRKYNYVAMD	TEFPGVVARP	IGEFRSNADY
70	80	90	100	110	120
QYQLLRCNVD	LLKIIQLGLT	FMNEQGEYPP	GTSTWQFNFK	FNLTEDMYAQ	DSIELLTTSG
130	140	150	160	170	180
IQFKKHEEEG	IETQYFAELL	MTSGVVLCEG	VKWLSFHSGY	DFGYLIKILT	NSNLPEEELD
190	200	210	220	230	240
FFEILRLFFP	VIYDVKYLMK	SCKNLKGGLQ	EVAEQLELER	IGPQHQAGSD	SLLTGMAFFK
250	260	270	280
MREMFFEDHI	DDAKYCGHLY	GLGSGSSYVQ	NGTGNAYEEE	ANKQS