A4II96
Gene name |
cnot7 (caf1) |
Protein name |
CCR4-NOT transcription complex subunit 7 |
Names |
CCR4-associated factor 1, CAF-1 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:100124970 |
EC number |
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4II96
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4II96-F1 | Predicted | AlphaFoldDB |
No variants for A4II96
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A4II96 | |||||
No associated diseases with A4II96
No regional properties for A4II96
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A4II96 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.13.4 | Exoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| CCR4-NOT complex | The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. |
| CCR4-NOT core complex | The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. |
| metal ion binding | Binding to a metal ion. |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic catabolism of deadenylated mRNA | The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. |
| positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZC01 | CNOT7 | CCR4-NOT transcription complex subunit 7 | Bos taurus (Bovine) | PR |
| Q5ZJV9 | CNOT7 | CCR4-NOT transcription complex subunit 7 | Gallus gallus (Chicken) | PR |
| Q9UIV1 | CNOT7 | CCR4-NOT transcription complex subunit 7 | Homo sapiens (Human) | PR |
| Q60809 | Cnot7 | CCR4-NOT transcription complex subunit 7 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPAATVDLSQ | RICEVWACNL | DDQMKRIRQV | IRKYNYVAMD | TEFPGVVARP | IGEFRSNADY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QYQLLRCNVD | LLKIIQLGLT | FVNEQGEYPP | GTSTWQFNFK | FNLTEDMYAQ | DSIELLTSSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQFKKHEEEG | IETQYFAELF | MTSGVVLCEG | VKWLSFHSGY | DFGYLIKILT | NSNLPEVELD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FFEILRLFFP | VIYDVKYLMK | SCKNLKGGLQ | EVAEQLELKR | IGPQHQAGSD | SLLTGMAFFK |
| 250 | 260 | 270 | 280 | ||
| MREMFFEDHI | DDAKYCGHLY | GLGSGSSYVQ | NGTGNAYEEE | ANKQS |