AiPD: Autoinhibited Protein Database

Q9UBN1

Gene name	CACNG4
Protein name	Voltage-dependent calcium channel gamma-4 subunit
Names	Neuronal voltage-gated calcium channel gamma-4 subunit, Transmembrane AMPAR regulatory protein gamma-4, TARP gamma-4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27092
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

195-286 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

195-286 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UBN1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UBN1-F1	Predicted				AlphaFoldDB

230 variants for Q9UBN1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1598096754 CA400687325	2	V>G		No	ClinGen Ensembl
CA400687326 rs1290442329	3	R>G		No	ClinGen TOPMed
rs1364390557 CA400687328	3	R>Q		No	ClinGen gnomAD
CA400687336 rs1410874768	4	C>Y		No	ClinGen TOPMed
rs780252263 CA8721587	6	R>P		No	ClinGen ExAC gnomAD
CA8721589 rs768937082	7	G>R		No	ClinGen ExAC gnomAD
CA400687378 rs1439174114	10	M>I		No	ClinGen TOPMed
rs1349965849 CA400687380	11	L>V		No	ClinGen TOPMed
CA8721590 rs781066654	14	T>M		No	ClinGen ExAC gnomAD
rs1289759239 CA400687404	15	A>G		No	ClinGen gnomAD
CA400687400 rs1230238086	15	A>T		No	ClinGen TOPMed gnomAD
rs866713299 CA293162840	20	A>D		No	ClinGen Ensembl
CA400687448 rs1331489369	22	S>*		No	ClinGen TOPMed
CA400687450 rs1331489369	22	S>L		No	ClinGen TOPMed
rs1254621340 CA400687446	22	S>P		No	ClinGen gnomAD
CA293162841 rs868475132	25	A>T		No	ClinGen Ensembl
rs1482347470 CA400687491	29	G>S		No	ClinGen gnomAD
rs1181588942 CA400687518	32	Y>*		No	ClinGen gnomAD
CA293162843 rs564332565	34	L>M		No	ClinGen ExAC gnomAD
rs759399090 CA8721594	34	L>R		No	ClinGen ExAC TOPMed gnomAD
rs775368039 CA8721596	37	S>R		No	ClinGen ExAC TOPMed gnomAD
rs760174920 CA8721597	39	H>L		No	ClinGen ExAC gnomAD
CA400687571 rs1309269637	40	I>M		No	ClinGen gnomAD
CA400687566 rs1357512435	40	I>V		No	ClinGen gnomAD
rs1334654661 CA400687589	43	G>R		No	ClinGen gnomAD
rs761432718 CA8721600	45	N>S		No	ClinGen ExAC
CA400687617 rs1445467751	47	T>I		No	ClinGen TOPMed gnomAD
CA400687618 rs1358950096 CA400687620	48	M>L		No	ClinGen TOPMed gnomAD
CA400687619 rs1358950096	48	M>V		No	ClinGen TOPMed gnomAD
rs1467171307 CA400687636	50	D>H		No	ClinGen TOPMed
rs1467171307 CA400687637	50	D>Y		No	ClinGen TOPMed
rs758752801 CA8721603	51	G>W		No	ClinGen ExAC gnomAD
CA8721605 rs751958946	52	P>L		No	ClinGen ExAC TOPMed gnomAD
rs780342055 CA8721604	52	P>S		No	ClinGen ExAC gnomAD
rs781501745 CA8721607	53	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8721608 rs748144448	53	P>Q		No	ClinGen ExAC gnomAD
CA400687656 rs1296665969	54	P>T		No	ClinGen Ensembl
rs866103390 CA293162936	55	R>H		No	ClinGen TOPMed
CA400687665 rs866103390	55	R>P		No	ClinGen TOPMed
rs1169983327 CA400687681	58	R>C		No	ClinGen TOPMed gnomAD
rs1169983327 CA400687680	58	R>G		No	ClinGen TOPMed gnomAD
CA400687683 rs1387782646	58	R>P		No	ClinGen gnomAD
rs1404180079 CA400687699	61	L>I		No	ClinGen gnomAD
CA400687708 rs1238373565	62	T>S		No	ClinGen gnomAD
rs1598096898 CA400687755	69	V>G		No	ClinGen Ensembl
rs778981141 CA8721610	70	C>F		No	ClinGen ExAC gnomAD
rs1354971794 CA400687773	72	I>V		No	ClinGen gnomAD
COSM1750241 rs1258618666 CA400690150	74	G>E	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs868611942 CA293162948	74	G>R		No	ClinGen Ensembl
CA400690154 rs1303889244	75	I>V		No	ClinGen TOPMed
rs1390279729 CA400690172	77	K>R		No	ClinGen TOPMed
CA293187374 rs866944756	81	F>I		No	ClinGen Ensembl
rs201531279 CA8721657	82	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1721629 CA8721656 rs758357413	82	R>W	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1412530029 CA400690269	84	N>S		No	ClinGen TOPMed gnomAD
rs1194651759 CA400690332	88	E>D		No	ClinGen TOPMed
CA293187412 rs768565187	89	D>H		No	ClinGen ExAC TOPMed gnomAD
CA8721659 rs768565187	89	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1219255342 CA400690349	90	N>H		No	ClinGen gnomAD
rs200886756 CA293187414	92	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1453288345 COSM294209 CA400690396	93	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs772670298 CA8721663	97	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA400690503 rs1284709622	99	Y>F		No	ClinGen TOPMed
rs964813318 CA293187467	101	L>F		No	ClinGen TOPMed
CA293193256 rs920965378	103	I>T		No	ClinGen TOPMed gnomAD
CA8721694 rs781015406	104	V>A		No	ClinGen ExAC gnomAD
rs111539823 CA8721692	104	V>L		No	ClinGen ExAC gnomAD
CA8721693 rs111539823	104	V>M		No	ClinGen ExAC gnomAD
CA8721695 COSM1385373 rs141844181	105	R>*	large_intestine Variant assessed as Somatic; 5.822e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA400691471 rs1466892036	105	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs35104874 CA8721698	109	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA400691587 rs1212232030	115	T>A		No	ClinGen gnomAD
CA400691585 rs1212232030	115	T>P		No	ClinGen gnomAD
TCGA novel	117	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400691661 rs1203286027	121	G>D		No	ClinGen gnomAD
CA293193311 rs896547023	125	I>V		No	ClinGen TOPMed gnomAD
rs1184803592 CA400691713 COSM1130193	126	G>S	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA8721705 rs761113164	130	I>M		No	ClinGen ExAC TOPMed gnomAD
CA8721706 rs79368381	131	Y>S		No	ClinGen ExAC gnomAD
CA293193346 rs905485925	133	R>C		No	ClinGen TOPMed gnomAD
CA8721709 rs576033468	133	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs576033468 CA8721708	133	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8721711 rs762993412	135	N>D		No	ClinGen ExAC gnomAD
rs368186078 CA8721712	137	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA400691856 rs535107281	138	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8721714 rs535107281	138	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753605926 CA8721716	140	S>G		No	ClinGen ExAC gnomAD
TCGA novel	141	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867745736 CA293193398	142	G>D		No	ClinGen Ensembl
rs778475274 CA8721718 COSM252406	142	G>S	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA293193402 rs892610491	143	I>M		No	ClinGen Ensembl
CA293193424 rs753058412	146	V>M		No	ClinGen TOPMed gnomAD
CA8721720 rs757910048	147	A>T		No	ClinGen ExAC gnomAD
CA400693962 rs1289644583	149	G>A		No	ClinGen gnomAD
rs1359441937 CA400693971	151	S>C		No	ClinGen gnomAD
rs759660487 CA8721754	153	I>V		No	ClinGen ExAC gnomAD
rs1275655031 CA400693993	154	I>V		No	ClinGen gnomAD
CA8721755 rs763983450	155	G>S		No	ClinGen ExAC TOPMed gnomAD
rs776495231 CA8721756	158	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8721758 rs764880228	163	N>D		No	ClinGen ExAC gnomAD
TCGA novel	163	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8721759 rs750240349	166	D>E		No	ClinGen ExAC
rs1429761313 CA400694080	167	P>L		No	ClinGen TOPMed gnomAD
CA8721761 rs766155308	169	D>G		No	ClinGen ExAC gnomAD
TCGA novel	169	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA293196630 rs910219206	170	K>E		No	ClinGen TOPMed
rs910219206 CA293196627	170	K>Q		No	ClinGen TOPMed
CA400694099 rs1409179857	170	K>T		No	ClinGen gnomAD
CA8721762 rs371128228	171	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1334540214 CA400694105	171	R>W		No	ClinGen TOPMed gnomAD
CA400694118 rs1313086207	173	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA400694128 rs1382146559	174	D>G		No	ClinGen gnomAD
rs781720730 CA8721766 CA8721764	176	K>N		No	ClinGen ExAC gnomAD
CA400694155 rs777957813	178	H>N		No	ClinGen ExAC gnomAD
rs777957813 CA8721767	178	H>Y		No	ClinGen ExAC gnomAD
rs200930655 CA8721770	184	S>A		No	ClinGen ExAC gnomAD
rs779141825 CA8721771	184	S>C		No	ClinGen ExAC gnomAD
CA8721772 rs779141825	184	S>F		No	ClinGen ExAC gnomAD
CA8721773 rs779141825 COSM1680018	184	S>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs769804633 CA8721777	186	Y>*		No	ClinGen ExAC gnomAD
rs775650159 CA8721775	186	Y>F		No	ClinGen ExAC gnomAD
CA8721776 rs775650159	186	Y>S		No	ClinGen ExAC gnomAD
CA8721778 rs772838264	187	F>L		No	ClinGen ExAC gnomAD
CA400694219 rs1435294988	187	F>S		No	ClinGen TOPMed
CA8721779 rs762893640	188	G>*		No	ClinGen ExAC gnomAD
CA400694227 rs1475025442	189	A>T		No	ClinGen gnomAD
rs1185672737 CA400694235	190	L>P		No	ClinGen gnomAD
CA8721781 rs147716893	197	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147716893 CA400694282	197	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766880996 CA8721783	198	V>M		No	ClinGen ExAC gnomAD
CA8721785 rs761954756	200	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8721786 rs778392195	202	A>T		No	ClinGen ExAC gnomAD
CA400694310 rs1227324723	203	V>I		No	ClinGen TOPMed gnomAD
rs1598129271 CA400694328	205	I>T		No	ClinGen Ensembl
CA8721787 rs754169853	207	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA400694340 rs1284421377	207	I>V		No	ClinGen TOPMed gnomAD
CA8721788 rs757682065	208	E>K		No	ClinGen ExAC gnomAD
CA8721790 rs199939691	212	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA8721791 rs772341192	213	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1598129303 CA400694391	214	R>K		No	ClinGen Ensembl
CA8721792 rs779960691	216	K>E		No	ClinGen ExAC TOPMed gnomAD
rs970783926 CA293196749	218	K>E		No	ClinGen TOPMed gnomAD
CA293196759 rs1002246421	219	R>Q		No	ClinGen TOPMed gnomAD
rs747138146 COSM243462 CA8721793	219	R>W	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1213632412 CA400694435	221	F>I		No	ClinGen TOPMed
TCGA novel	222	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1454495826 CA400694460	224	A>V		No	ClinGen TOPMed gnomAD
CA400694464 rs1382898107	225	S>P		No	ClinGen gnomAD
CA8721795 rs200489504	227	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA8721796 rs762838519	228	S>C		No	ClinGen ExAC gnomAD
CA8721797 rs770908900	233	M>R		No	ClinGen ExAC gnomAD
rs774303379 CA8721798	234	P>L		No	ClinGen ExAC gnomAD
TCGA novel	237	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752125531 CA8721801	239	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8721800 rs767219625	239	R>W		No	ClinGen ExAC TOPMed gnomAD
CA400694560 rs1271021237	240	R>*		No	ClinGen gnomAD
rs760271953 CA400694561	240	R>P		No	ClinGen ExAC gnomAD
rs760271953 CA8721802	240	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1250950895 CA400694567	241	R>Q		No	ClinGen TOPMed gnomAD
CA400694564 rs1198502508	241	R>W		No	ClinGen gnomAD
rs375347933 CA8721803	242	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs202135500 CA8721804	242	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs757772003 COSM983198 CA8721805	243	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1164270280 CA400694579	244	R>K		No	ClinGen gnomAD
CA400694582 rs780374055	244	R>S		No	ClinGen ExAC gnomAD
rs1417700053 CA400694585	245	S>P		No	ClinGen TOPMed
rs747028631 CA8721810	246	S>N		No	ClinGen ExAC gnomAD
rs989387905 CA293196824	246	S>R		No	ClinGen TOPMed gnomAD
rs200921531 CA293196830	247	S>P		No	ClinGen TOPMed
rs1567761455 CA400694611	249	S>Y		No	ClinGen Ensembl
rs755157652 CA8721811	250	T>A		No	ClinGen ExAC gnomAD
rs370622371 CA293196837	251	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA400694628 rs1334779642	252	A>S		No	ClinGen gnomAD
CA400694637 COSM380914 rs1230291904	253	S>L	lung Variant assessed as Somatic; impact. breast [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA293196855 rs376262241 CA8721816	258	V>L		No	ClinGen ExAC gnomAD
rs376262241 CA8721817	258	V>M		No	ClinGen ExAC gnomAD
CA400694672 rs1481510444	259	S>L		No	ClinGen gnomAD
CA293196868 rs932358745	261	M>I		No	ClinGen TOPMed gnomAD
rs1274702846 CA400694693	262	G>D		No	ClinGen TOPMed
CA400694696 rs1184362272	263	L>Q		No	ClinGen gnomAD
TCGA novel	264	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	264	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400694703 rs1279592730	264	K>R		No	ClinGen gnomAD
CA400694715 rs1387149745	266	T>A		No	ClinGen gnomAD
rs1233357194 CA400694726	268	A>T		No	ClinGen TOPMed
CA293196871 rs1049519654	269	I>L		No	ClinGen TOPMed
rs929227780 CA293196872	270	P>T		No	ClinGen TOPMed gnomAD
CA400694749 rs1296775828	271	M>I		No	ClinGen gnomAD
CA400694747 rs1567761503	271	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs866333708 CA293196875	273	E>K		No	ClinGen Ensembl
TCGA novel	275	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567761508 CA400694771	275	S>P		No	ClinGen Ensembl
CA293196881 rs762265124	276	M>R		No	ClinGen ExAC TOPMed gnomAD
CA8721823 rs762265124	276	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8721822 rs776121743	276	M>V		No	ClinGen ExAC gnomAD
rs1258502203 CA400694795	278	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8721824 rs149010646	279	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA8721825 rs371870032	282	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1378871517 CA400694826	284	L>I		No	ClinGen TOPMed gnomAD
rs1204567430 CA400694850	287	T>S		No	ClinGen gnomAD
CA8721830 rs781356523	289	A>E		No	ClinGen ExAC gnomAD
rs375114114 CA8721829	289	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA400694866 rs1409412572	290	A>G		No	ClinGen TOPMed
rs1430803175 CA400694862	290	A>T		No	ClinGen gnomAD
CA8721832 rs115238163	295	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8721833 rs569774258	296	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8721834 rs373248340	298	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs771955211 CA8721835	299	S>N		No	ClinGen ExAC gnomAD
CA400694940 rs1294697731	301	L>M		No	ClinGen gnomAD
CA8721836 rs775161356	301	L>R		No	ClinGen ExAC TOPMed gnomAD
CA8721837 rs746604287	302	Q>H		No	ClinGen ExAC gnomAD
CA293196987 rs1007043136	303	V>L		No	ClinGen gnomAD
TCGA novel	304	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8721838 rs768326835	304	H>R		No	ClinGen ExAC gnomAD
CA8721839 rs776072571	305	D>N		No	ClinGen ExAC gnomAD
TCGA novel	307	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317413380 CA400695012	311	L>V		No	ClinGen TOPMed
rs1486853842 CA400695021	312	K>T		No	ClinGen gnomAD
rs893913240 CA293196997	314	G>S		No	ClinGen TOPMed
rs765702561 CA8721841	315	F>L		No	ClinGen ExAC gnomAD
rs137899115 CA293197010	316	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs762818108 CA8721843	317	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1413552230 CA400695192	319	M>I		No	ClinGen gnomAD
rs561608193 CA293197017	319	M>K		No	ClinGen TOPMed
CA8721845 rs751878206	322	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA400695274 rs1427963530	323	R>G		No	ClinGen TOPMed gnomAD
CA8721846 rs140902954	323	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA400695277 rs1427963530	323	R>W		No	ClinGen TOPMed gnomAD
CA8721847 rs767898217	324	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1598129687 CA400695317	325	T>P		No	ClinGen Ensembl

No associated diseases with Q9UBN1

2 regional properties for Q9UBN1

Type	Name	Position	InterPro Accession
domain	C2 domain	1 - 111	IPR000008
domain	C2CD5, C2 domain	5 - 114	IPR037785

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
AMPA glutamate receptor complex	An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cell surface	The external part of the cell wall and/or plasma membrane.
endocytic vesicle membrane	The lipid bilayer surrounding an endocytic vesicle.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic density membrane	The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
L-type voltage-gated calcium channel complex	A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density membrane	The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
somatodendritic compartment	The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.

4 GO annotations of molecular function

Name	Definition
calcium channel regulator activity	Modulates the activity of a calcium channel.
channel regulator activity	Bonds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel.
ionotropic glutamate receptor binding	Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
voltage-gated calcium channel activity	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

9 GO annotations of biological process

Name	Definition
neurotransmitter receptor internalization	A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor.
neurotransmitter receptor transport, postsynaptic endosome to lysosome	The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation.
positive regulation of AMPA receptor activity	Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity.
positive regulation of synaptic transmission, glutamatergic	Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
postsynaptic neurotransmitter receptor diffusion trapping	The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization.
regulation of AMPA receptor activity	Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity.
regulation of postsynaptic neurotransmitter receptor activity	Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors.
response to cocaine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
transmission of nerve impulse	The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9JJV4	Cacng4	Voltage-dependent calcium channel gamma-4 subunit	Mus musculus (Mouse)	PR
Q9JJV5	Cacng3	Voltage-dependent calcium channel gamma-3 subunit	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MVRCDRGLQM	LLTTAGAFAA	FSLMAIAIGT	DYWLYSSAHI	CNGTNLTMDD	GPPPRRARGD
70	80	90	100	110	120
LTHSGLWRVC	CIEGIYKGHC	FRINHFPEDN	DYDHDSSEYL	LRIVRASSVF	PILSTILLLL
130	140	150	160	170	180
GGLCIGAGRI	YSRKNNIVLS	AGILFVAAGL	SNIIGIIVYI	SSNTGDPSDK	RDEDKKNHYN
190	200	210	220	230	240
YGWSFYFGAL	SFIVAETVGV	LAVNIYIEKN	KELRFKTKRE	FLKASSSSPY	ARMPSYRYRR
250	260	270	280	290	300
RRSRSSSRST	EASPSRDVSP	MGLKITGAIP	MGELSMYTLS	REPLKVTTAA	SYSPDQEASF
310	320
LQVHDFFQQD	LKEGFHVSML	NRRTTPV