Q9JJV5
PR
Gene name |
Cacng3 |
Protein name |
Voltage-dependent calcium channel gamma-3 subunit |
Names |
Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3, TARP gamma-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54376 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JJV5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JJV5-F1 | Predicted | AlphaFoldDB |
16 variants for Q9JJV5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388947664 | 18 | F>L | No | EVA | |
| rs3388943937 | 30 | T>M | No | EVA | |
| rs3388947857 | 69 | L>V | No | EVA | |
| rs3388941825 | 81 | D>H | No | EVA | |
| rs3388924474 | 88 | D>E | No | EVA | |
| rs3388944113 | 93 | T>S | No | EVA | |
| rs3388944257 | 108 | P>H | No | EVA | |
| rs3388947837 | 137 | S>R | No | EVA | |
| rs3388902371 | 143 | V>D | No | EVA | |
| rs3388944320 | 158 | S>A | No | EVA | |
| rs3388934487 | 163 | D>V | No | EVA | |
| rs3388949613 | 164 | P>R | No | EVA | |
| rs3398359035 | 284 | R>Q | No | EVA | |
| rs3388948239 | 285 | D>Y | No | EVA | |
| rs3388928290 | 306 | N>K | No | EVA | |
| rs3388948203 | 309 | N>T | No | EVA |
No associated diseases with Q9JJV5
No regional properties for Q9JJV5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9JJV5 | |||
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| AMPA glutamate receptor complex | An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| excitatory synapse | A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
| somatodendritic compartment | The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| channel regulator activity | Bonds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. |
| ionotropic glutamate receptor binding | Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| voltage-gated calcium channel activity | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| neurotransmitter receptor internalization | A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor. |
| neurotransmitter receptor localization to postsynaptic specialization membrane | A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). |
| neurotransmitter receptor transport, postsynaptic endosome to lysosome | The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation. |
| positive regulation of AMPA receptor activity | Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity. |
| positive regulation of synaptic transmission, glutamatergic | Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| postsynaptic neurotransmitter receptor diffusion trapping | The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| protein targeting | The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. |
| regulation of AMPA receptor activity | Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity. |
| transmission of nerve impulse | The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRMCDRGIQM | LITTVGAFAA | FSLMTIAVGT | DYWLYSRGVC | RTKSTSDNET | SRKNEEVMTH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGLWRTCCLE | GAFRGVCKKI | DHFPEDADYE | QDTAEYLLRA | VRASSVFPIL | SVTLLFFGGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CVAASEFHRS | RHSVILSAGI | FFVSAGLSNI | IGIIVYISAN | AGDPGQRDSK | KSYSYGWSFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FGAFSFIIAE | IVGVVAVHIY | IEKHQQLRAR | SHSELLKKST | FARLPPYRYR | FRRRSSSRST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPRSRDLSPI | SKGFHTIPST | DISMFTLSRD | PSKLTMGTLL | NSDRDHAFLQ | FHNSTPKEFK |
| 310 | |||||
| ESLHNNPANR | RTTPV |