Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9SZX8

Entry ID Method Resolution Chain Position Source
AF-Q9SZX8-F1 Predicted AlphaFoldDB

66 variants for Q9SZX8

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00486414 6 S>T No 1000Genomes
ENSVATH06604220 10 H>N No 1000Genomes
ENSVATH06604219 11 Q>R No 1000Genomes
ENSVATH00486413 12 T>A No 1000Genomes
ENSVATH14122791 14 A>V No 1000Genomes
ENSVATH00486412 26 S>T No 1000Genomes
tmp_4_6461832_A_C 34 V>G No 1000Genomes
tmp_4_6461808_G_C 42 T>S No 1000Genomes
tmp_4_6461805_A_G 43 V>A No 1000Genomes
ENSVATH06604218 67 S>F No 1000Genomes
ENSVATH11442308 75 F>S No 1000Genomes
ENSVATH14122790 89 T>S No 1000Genomes
ENSVATH11442307 92 Y>H No 1000Genomes
ENSVATH00486406 97 E>D No 1000Genomes
tmp_4_6461544_T_C 130 K>R No 1000Genomes
tmp_4_6461520_A_G 138 I>T No 1000Genomes
tmp_4_6461485_A_T 150 W>R No 1000Genomes
tmp_4_6461385_C_T 183 R>H No 1000Genomes
tmp_4_6461379_C_T 185 R>K No 1000Genomes
tmp_4_6461353_G_A 194 P>S No 1000Genomes
tmp_4_6461320_C_A 205 A>S No 1000Genomes
tmp_4_6461289_A_T 215 I>N No 1000Genomes
tmp_4_6461136_C_G 240 V>L No 1000Genomes
tmp_4_6461132_G_A 241 S>F No 1000Genomes
tmp_4_6461115_T_C 247 T>A No 1000Genomes
ENSVATH06604209 249 E>V No 1000Genomes
tmp_4_6461057_A_G 266 I>T No 1000Genomes
ENSVATH02774881 271 R>* No 1000Genomes
tmp_4_6460903_C_T 296 G>S No 1000Genomes
ENSVATH11442305 310 G>S No 1000Genomes
ENSVATH06604204 334 D>N No 1000Genomes
tmp_4_6460756_C_G 345 V>L No 1000Genomes
ENSVATH06604202 346 A>G No 1000Genomes
tmp_4_6460753_C_A 346 A>S No 1000Genomes
ENSVATH14122787 357 K>N No 1000Genomes
tmp_4_6460712_G_C 359 D>E No 1000Genomes
ENSVATH11442222 370 I>V No 1000Genomes
ENSVATH02774880 379 N>K No 1000Genomes
tmp_4_6460633_T_A 386 S>C No 1000Genomes
ENSVATH00486396 392 S>F No 1000Genomes
ENSVATH14122786 397 D>E No 1000Genomes
ENSVATH06604197 403 T>I No 1000Genomes
ENSVATH00486394 409 N>H No 1000Genomes
ENSVATH06604195 409 N>K No 1000Genomes
ENSVATH02774876 411 P>L No 1000Genomes
tmp_4_6460456_G_A 418 A>V No 1000Genomes
ENSVATH11442220 420 E>V No 1000Genomes
tmp_4_6460409_T_G 434 I>L No 1000Genomes
ENSVATH00486392 440 E>D No 1000Genomes
ENSVATH14122785 447 R>G No 1000Genomes
ENSVATH14122774 454 K>Q No 1000Genomes
ENSVATH06604192 455 E>D No 1000Genomes
ENSVATH14122773 458 A>E No 1000Genomes
ENSVATH14122772 488 S>Y No 1000Genomes
ENSVATH06604186 551 C>Y No 1000Genomes
tmp_4_6459970_T_C 554 T>A No 1000Genomes
tmp_4_6459906_T_A 575 N>I No 1000Genomes
tmp_4_6459907_T_A 575 N>Y No 1000Genomes
tmp_4_6459904_C_G 576 V>L No 1000Genomes
ENSVATH02774873 579 L>V No 1000Genomes
tmp_4_6459861_T_G 590 K>T No 1000Genomes
ENSVATH02774871 603 F>S No 1000Genomes
tmp_4_6459796_C_T 612 V>I No 1000Genomes
tmp_4_6459774_T_C 619 Q>R No 1000Genomes
tmp_4_6459760_T_A 624 N>Y No 1000Genomes
ENSVATH02774870 625 N>K No 1000Genomes

No associated diseases with Q9SZX8

2 regional properties for Q9SZX8

Type Name Position InterPro Accession
domain F-box domain 10 - 51 IPR001810
domain Domain unknown function DUF295 287 - 331 IPR005174

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.

1 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C884 At1g33170 Probable methyltransferase PMT18 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIZ3 At2g40280 Probable methyltransferase PMT23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZW75 At2g43200 Probable methyltransferase PMT19 Arabidopsis thaliana (Mouse-ear cress) PR
Q84TJ0 At3g10200 Probable methyltransferase PMT6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZA4 At5g04060 Probable methyltransferase PMT7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKENSGHHH QTEARRKKLT LILGVSGLCI LFYVLGAWQA NTVPSSISKL GCETQSNPSS
70 80 90 100 110 120
SSSSSSSSES AELDFKSHNQ IELKETNQTI KYFEPCELSL SEYTPCEDRQ RGRRFDRNMM
130 140 150 160 170 180
KYRERHCPVK DELLYCLIPP PPNYKIPFKW PQSRDYAWYD NIPHKELSVE KAVQNWIQVE
190 200 210 220 230 240
GDRFRFPGGG TMFPRGADAY IDDIARLIPL TDGGIRTAID TGCGVASFGA YLLKRDIMAV
250 260 270 280 290 300
SFAPRDTHEA QVQFALERGV PAIIGIMGSR RLPYPARAFD LAHCSRCLIP WFKNDGLYLM
310 320 330 340 350 360
EVDRVLRPGG YWILSGPPIN WKQYWRGWER TEEDLKKEQD SIEDVAKSLC WKKVTEKGDL
370 380 390 400 410 420
SIWQKPLNHI ECKKLKQNNK SPPICSSDNA DSAWYKDLET CITPLPETNN PDDSAGGALE
430 440 450 460 470 480
DWPDRAFAVP PRIIRGTIPE MNAEKFREDN EVWKERIAHY KKIVPELSHG RFRNIMDMNA
490 500 510 520 530 540
FLGGFAASML KYPSWVMNVV PVDAEKQTLG VIYERGLIGT YQDWCEGFST YPRTYDMIHA
550 560 570 580 590 600
GGLFSLYEHR CDLTLILLEM DRILRPEGTV VLRDNVETLN KVEKIVKGMK WKSQIVDHEK
610 620 630
GPFNPEKILV AVKTYWTGQP SDKNNNNNNN NNN