Q9SMV6

PR
Gene name
XPO1
Protein name
Protein EXPORTIN 1A
Names
AtCRM1, AtXPO1, Protein HEAT-INTOLERANT 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G17020
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

352-430 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SMV6

Entry ID Method Resolution Chain Position Source
AF-Q9SMV6-F1 Predicted AlphaFoldDB

23 variants for Q9SMV6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03065935 32 E>D No 1000Genomes
ENSVATH10796348 109 A>S No 1000Genomes
tmp_5_5595940_T_A 111 F>Y No 1000Genomes
ENSVATH06979492 286 R>Q No 1000Genomes
tmp_5_5597175_A_C 294 K>T No 1000Genomes
ENSVATH14057395 303 S>N No 1000Genomes
ENSVATH10796378 317 F>C No 1000Genomes
ENSVATH10796415 330 S>T No 1000Genomes
tmp_5_5597781_C_T 374 A>V No 1000Genomes
ENSVATH00626419 397 M>I No 1000Genomes
tmp_5_5598028_C_G 410 Q>E No 1000Genomes
ENSVATH06979505 412 Y>F No 1000Genomes
tmp_5_5598042_C_G 414 H>Q No 1000Genomes
ENSVATH06979526 708 Y>F No 1000Genomes
ENSVATH10796538 723 V>A No 1000Genomes
tmp_5_5601098_A_G 824 H>R No 1000Genomes
tmp_5_5601307_A_T 858 I>F No 1000Genomes
ENSVATH10796569 918 R>Q No 1000Genomes
ENSVATH00626435 961 T>I No 1000Genomes
ENSVATH14057528 975 P>L No 1000Genomes
tmp_5_5602188_C_T 1015 P>L No 1000Genomes
ENSVATH14057529 1048 Q>H No 1000Genomes
tmp_5_5602390_A_G 1051 R>G No 1000Genomes

No associated diseases with Q9SMV6

6 regional properties for Q9SMV6

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 37 - 103 IPR001494
domain Exportin-1/Importin-beta-like 115 - 258 IPR013598
domain Exportin-1, C-terminal 712 - 1034 IPR014877
repeat Exportin-1, repeat 3 489 - 538 IPR040485
repeat Chromosome region maintenance repeat 337 - 372 IPR041123
repeat Exportin-1, repeat 2 408 - 475 IPR041235

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
  • Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

9 GO annotations of biological process

Name Definition
embryo sac development The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
pollen development The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
pollen germination The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture.
pollen tube growth Growth of pollen via tip extension of the intine wall.
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P30822 CRM1 Exportin-1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q96QU8 XPO6 Exportin-6 Homo sapiens (Human) PR
Q924Z6 Xpo6 Exportin-6 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAEKLRDLS QPIDVGVLDA TVAAFFVTGS KEERAAADQI LRDLQANPDM WLQVVHILQN
70 80 90 100 110 120
TNSLDTKFFA LQVLEGVIKY RWNALPVEQR DGMKNYISEV IVQLSSNEAS FRSERLYVNK
130 140 150 160 170 180
LNVILVQIVK HDWPAKWTSF IPDLVAAAKT SETICENCMA ILKLLSEEVF DFSRGEMTQQ
190 200 210 220 230 240
KIKELKQSLN SEFKLIHELC LYVLSASQRQ DLIRATLSAL HAYLSWIPLG YIFESTLLET
250 260 270 280 290 300
LLKFFPVPAY RNLTIQCLTE VAALNFGDFY NVQYVKMYTI FIGQLRIILP PSTKIPEAYS
310 320 330 340 350 360
SGSGEEQAFI QNLALFFTSF FKFHIRVLES TPEVVSLLLA GLEYLINISY VDDTEVFKVC
370 380 390 400 410 420
LDYWNSLVLE LFDAHHNSDN PAVSASLMGL QPFLPGMVDG LGSQVMQRRQ LYSHPMSKLR
430 440 450 460 470 480
GLMINRMAKP EEVLIVEDEN GNIVRETMKD NDVLVQYKIM RETLIYLSHL DHDDTEKQML
490 500 510 520 530 540
RKLNKQLSGE EWAWNNLNTL CWAIGSISGS MAEDQENRFL VMVIRDLLNL CEITKGKDNK
550 560 570 580 590 600
AVIASNIMYV VGQYPRFLRA HWKFLKTVVN KLFEFMHETH PGVQDMACDT FLKIVQKCKR
610 620 630 640 650 660
KFVIVQVGEN EPFVSELLTG LATTVQDLEP HQIHSFYESV GNMIQAESDP QKRDEYLQRL
670 680 690 700 710 720
MALPNQKWAE IIGQARHSVE FLKDQVVIRT VLNILQTNTS AATSLGTYFL SQISLIFLDM
730 740 750 760 770 780
LNVYRMYSEL VSTNITEGGP YASKTSFVKL LRSVKRETLK LIETFLDKAE DQPHIGKQFV
790 800 810 820 830 840
PPMMESVLGD YARNVPDARE SEVLSLFATI INKYKATMLD DVPHIFEAVF QCTLEMITKN
850 860 870 880 890 900
FEDYPEHRLK FFSLLRAIAT FCFPALIKLS SPQLKLVMDS IIWAFRHTER NIAETGLNLL
910 920 930 940 950 960
LEMLKNFQQS EFCNQFYRSY FMQIEQEIFA VLTDTFHKPG FKLHVLVLQQ LFCLPESGAL
970 980 990 1000 1010 1020
TEPLWDATTV PYPYPDNVAF VREYTIKLLS SSFPNMTAAE VTQFVNGLYE SRNDPSGFKN
1030 1040 1050 1060 1070
NIRDFLVQSK EFSAQDNKDL YAEEAAAQRE RERQRMLSIP GLIAPNEIQD EMVDS