Q924Z6

PR
Gene name
Xpo6 (Ranbp20)
Protein name
Exportin-6
Names
Exp6, Ran-binding protein 20
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74204
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-258 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q924Z6

Entry ID Method Resolution Chain Position Source
AF-Q924Z6-F1 Predicted AlphaFoldDB

51 variants for Q924Z6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388948737 61 M>L No EVA
rs251986139 88 R>C No EVA
rs3388940773 129 F>L No EVA
rs3388951237 174 K>M No EVA
rs3398601535 175 L>Q No EVA
rs3388948537 188 T>K No EVA
rs3388949687 204 T>N No EVA
rs234952345 229 K>E No EVA
rs213543209 230 L>R No EVA
rs250973599 232 H>Q No EVA
rs3388925810 232 H>Y No EVA
rs3388946596 234 P>L No EVA
rs231675319 244 Y>S No EVA
rs3388935932 400 L>I No EVA
rs3388903390 407 H>L No EVA
rs216963208 433 K>R No EVA
rs3388948533 493 S>* No EVA
rs3388935937 493 S>R No EVA
rs3388951202 494 L>* No EVA
rs3388945532 496 V>I No EVA
rs3388919581 507 H>R No EVA
rs3388940849 509 F>I No EVA
rs3388951267 537 H>Y No EVA
rs3388929724 554 L>M No EVA
rs3388951837 559 S>F No EVA
rs3388948553 604 N>D No EVA
rs3388919572 619 D>G No EVA
rs3388949714 629 Q>P No EVA
rs260398389 640 G>S No EVA
rs3388903381 642 A>T No EVA
rs3388919579 677 A>V No EVA
rs3388949719 692 F>V No EVA
rs3388948556 694 I>V No EVA
rs3388945325 757 A>T No EVA
rs3388951803 759 S>P No EVA
rs3388948729 767 P>A No EVA
rs3388925778 774 R>S No EVA
rs3411268580 785 I>M No EVA
rs3398615373 787 Q>K No EVA
rs3388951205 793 E>K No EVA
rs3388940826 800 S>Y No EVA
rs3398601538 846 F>L No EVA
rs3398118720 884 T>S No EVA
rs3388903364 890 E>G No EVA
rs3388945528 907 F>Y No EVA
rs3388945346 985 G>* No EVA
rs3388945523 992 D>G No EVA
rs3388919589 1016 K>R No EVA
rs3388945368 1043 Q>H No EVA
rs3388903388 1100 N>Y No EVA
rs3388925781 1105 V>I No EVA

No associated diseases with Q924Z6

2 regional properties for Q924Z6

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 31 - 97 IPR001494
domain Exportin-1/Importin-beta-like 103 - 277 IPR013598

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Shuttles between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

1 GO annotations of biological process

Name Definition
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96QU8 XPO6 Exportin-6 Homo sapiens (Human) PR
Q9SMV6 XPO1 Protein EXPORTIN 1A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QVGAWRFCLY FLSSTRNDYV
70 80 90 100 110 120
MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK TLPYFIRNKL CKVIVDIGRQ
130 140 150 160 170 180
DWPMFYHDFF TNILQLIQSP VTTPLGLIML KTTSEELACP REDLSVARKE ELRKLLLDQV
190 200 210 220 230 240
QTVLGLLTGI LETVWDKHSV TAATPPPSPT SGESGDLLSN LLQSPSSAKL LHQPIPILDV
250 260 270 280 290 300
ESEYVCSLAL ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDTRARKMA SVNGSSQNCV
310 320 330 340 350 360
LGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD NNAHTVKSRL
370 380 390 400 410 420
EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL LFKYTFHQPT HEGYFSCLDI
430 440 450 460 470 480
WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL VLLLTEVLNR IQFRYNQAQL EELDDETLDD
490 500 510 520 530 540
DQQTEWQRYL RQSLEVVAKV MELLPTHAFS TLFPVLQDNL EVYLGLQQFV VTSGSGHRLN
550 560 570 580 590 600
ITAENDCRRL HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
610 620 630 640 650 660
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCG EAHRQNTQQF VTLISTTMDA
670 680 690 700 710 720
ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ KVFNSIIDAS AQRLTDKAQV
730 740 750 760 770 780
LVCRALSNTL LLPWPNLPES EQQWPLRSIN HASLISALSR DYHSLKPSAT APQRKVPLGD
790 800 810 820 830 840
TKVIIHQTLS VLEDIVENIS GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS
850 860 870 880 890 900
FFLTLFRGLR VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
910 920 930 940 950 960
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW RYFFKSTVLA
970 980 990 1000 1010 1020
SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL FYLETLNTKQ KLYHKKIFRT
1030 1040 1050 1060 1070 1080
TMLFQFVNVL LQVLVHKSHD LLQEEIGIAI YNMASVDFDG FFAAFLPEFL TSCDGVDANQ
1090 1100 1110 1120
KNVLGRNFKM DRDLPSFTQN VHRLVNDLRY YRLCNDSLPP GTVKL