P30822

PR
Gene name
CRM1 (KAP124, XPO1, YGR218W, G8514)
Protein name
Exportin-1
Names
Chromosome region maintenance protein 1, Karyopherin-124
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR218W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1034-1084 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

69 structures for P30822

Entry ID Method Resolution Chain Position Source
3M1I X-ray 200 A C 1-1084 PDB
3VYC X-ray 210 A A 1-1084 PDB
3WYF X-ray 222 A C/F 1-1084 PDB
3WYG X-ray 215 A C 1-1084 PDB
4GMX X-ray 210 A C 1-1058 PDB
4GPT X-ray 222 A C 1-1058 PDB
4HAT X-ray 178 A C 1-1058 PDB
4HAU X-ray 200 A C 1-1058 PDB
4HAV X-ray 200 A C 1-1058 PDB
4HAW X-ray 190 A C 1-1058 PDB
4HAX X-ray 228 A C 1-1058 PDB
4HAY X-ray 230 A C 1-1058 PDB
4HAZ X-ray 190 A C 1-1058 PDB
4HB0 X-ray 220 A C 1-1058 PDB
4HB2 X-ray 180 A C 1-1058 PDB
4HB3 X-ray 280 A C 1-1058 PDB
4HB4 X-ray 205 A C 1-1058 PDB
5DH9 X-ray 255 A C 1-1058 PDB
5DHA X-ray 295 A C 1-1058 PDB
5DHF X-ray 229 A C 1-1058 PDB
5DI9 X-ray 228 A C 1-1058 PDB
5DIF X-ray 209 A C 1-1058 PDB
5JLJ X-ray 250 A C 1-1058 PDB
5UWH X-ray 226 A C 1-1058 PDB
5UWI X-ray 214 A C 1-1058 PDB
5UWJ X-ray 222 A C 1-1058 PDB
5UWO X-ray 235 A C 1-1058 PDB
5UWP X-ray 205 A C 1-1058 PDB
5UWQ X-ray 228 A C 1-1058 PDB
5UWR X-ray 224 A C 1-1058 PDB
5UWS X-ray 240 A C 1-1058 PDB
5UWT X-ray 234 A C 1-1058 PDB
5UWU X-ray 224 A C 1-1058 PDB
5UWW X-ray 215 A C 1-1058 PDB
5XOJ X-ray 220 A C 1-1084 PDB
5YRO X-ray 240 A C 1-1058 PDB
5YST X-ray 204 A C 1-1052 PDB
5YSU X-ray 230 A C 1-1055 PDB
5YTB X-ray 230 A C 1-1052 PDB
5ZPU X-ray 260 A C 1-1058 PDB
6A38 X-ray 269 A C 1-1058 PDB
6A3A X-ray 230 A C 1-1058 PDB
6A3B X-ray 251 A C 1-1058 PDB
6A3C X-ray 235 A C 1-1058 PDB
6A3E X-ray 270 A C 1-1058 PDB
6CIT X-ray 203 A C 1-1058 PDB
6KFT X-ray 251 A C 1-1058 PDB
6LQ9 X-ray 250 A C 1-1058 PDB
6M60 X-ray 217 A C 1-1058 PDB
6M6X X-ray 288 A C 1-1058 PDB
6X2M X-ray 235 A C 1-1058 PDB
6X2O X-ray 255 A C 1-1058 PDB
6X2P X-ray 240 A C 1-1058 PDB
6X2R X-ray 230 A C 1-1058 PDB
6X2S X-ray 250 A C 1-1058 PDB
6X2U X-ray 220 A C 1-1058 PDB
6X2V X-ray 282 A C 1-1058 PDB
6X2W X-ray 300 A C 1-1058 PDB
6X2X X-ray 246 A C 1-1058 PDB
6X2Y X-ray 230 A C 1-1058 PDB
6XJP X-ray 280 A C 1-1058 PDB
6XJR X-ray 194 A C 1-1058 PDB
6XJS X-ray 194 A C 1-1058 PDB
6XJT X-ray 241 A C 1-1058 PDB
6XJU X-ray 219 A C 1-1058 PDB
7CND X-ray 180 A C 1-1058 PDB
7DBG X-ray 206 A C 1-1058 PDB
7L5E X-ray 194 A C 1-1058 PDB
AF-P30822-F1 Predicted AlphaFoldDB

2 variants for P30822

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-932782 80 K>R No SGRP
s07-933348 269 D>H No SGRP

No associated diseases with P30822

6 regional properties for P30822

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 34 - 100 IPR001494
domain Exportin-1/Importin-beta-like 111 - 256 IPR013598
domain Exportin-1, C-terminal 720 - 1044 IPR014877
repeat Exportin-1, repeat 3 496 - 546 IPR040485
repeat Chromosome region maintenance repeat 338 - 374 IPR041123
repeat Exportin-1, repeat 2 416 - 483 IPR041235

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, perinuclear region
  • Localized in the nucleus and at its periphery
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
spindle pole body The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.

8 GO annotations of molecular function

Name Definition
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.
U1 snRNA binding Binding to a U1 small nuclear RNA (U1 snRNA).
U2 snRNA binding Binding to a U2 small nuclear RNA (U2 snRNA).
U4 snRNA binding Binding to a U4 small nuclear RNA (U4 snRNA).
U5 snRNA binding Binding to a U5 small nuclear RNA (U5 snRNA).
U6 snRNA binding Binding to a U6 small nuclear RNA (U6 snRNA).

6 GO annotations of biological process

Name Definition
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
nuclear export The directed movement of substances out of the nucleus.
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52918 MSN5 Protein MSN5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9SMV6 XPO1 Protein EXPORTIN 1A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK ADQILQFSTN
70 80 90 100 110 120
PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS MCQDDEVFKT QKNLINKSDL
130 140 150 160 170 180
TLVQILKQEW PQNWPEFIPE LIGSSSSSVN VCENNMIVLK LLSEEVFDFS AEQMTQAKAL
190 200 210 220 230 240
HLKNSMSKEF EQIFKLCFQV LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST
250 260 270 280 290 300
KFMTSPDTRA ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
310 320 330 340 350 360
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL SKIEERELFK
370 380 390 400 410 420
TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST GSGALNPEYM KRFPLKKHIY
430 440 450 460 470 480
EEICSQLRLV IIENMVRPEE VLVVENDEGE IVREFVKESD TIQLYKSERE VLVYLTHLNV
490 500 510 520 530 540
IDTEEIMISK LARQIDGSEW SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV
550 560 570 580 590 600
KKRGKDNKAV VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
610 620 630 640 650 660
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI IISEERSVAE
670 680 690 700 710 720
RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA NIIKTNVAVC TSMGADFYPQ
730 740 750 760 770 780
LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA TKTPKVRGLR TIKKEILKLV ETYISKARNL
790 800 810 820 830 840
DDVVKVLVEP LLNAVLEDYM NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC
850 860 870 880 890 900
TLDMINKDFT EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
910 920 930 940 950 960
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS GFSKQALLLM
970 980 990 1000 1010 1020
KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS NAFPHLTSEQ IASFLSALTK
1030 1040 1050 1060 1070 1080
QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL FAEDKENALM EQNRLEREKA AKIGGLLKPS
ELDD