P52918
Gene name |
MSN5 (YDR335W, D9651.5) |
Protein name |
Protein MSN5 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR335W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52918
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52918-F1 | Predicted | AlphaFoldDB |
10 variants for P52918
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1141277 | 39 | C>S | No | SGRP | |
| s04-1141364 | 68 | D>G | No | SGRP | |
| s04-1141421 | 87 | R>T | No | SGRP | |
| s04-1142108 | 316 | D>G | No | SGRP | |
| s04-1142761 | 534 | K>E | No | SGRP | |
| s04-1143571 | 804 | P>T | No | SGRP | |
| s04-1143722 | 854 | A>D | No | SGRP | |
| s04-1143937 | 926 | I>L | No | SGRP | |
| s04-1144478 | 1106 | A>V | No | SGRP | |
| s04-1144558 | 1133 | N>H | No | SGRP |
No associated diseases with P52918
1 regional properties for P52918
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exportin-5, C-terminal domain | 332 - 1186 | IPR045478 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA nuclear export complex | A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear export signal receptor activity | Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein export from nucleus | The directed movement of a protein from the nucleus into the cytoplasm. |
| RNA export from nucleus | The directed movement of RNA from the nucleus to the cytoplasm. |
| tRNA re-export from nucleus | The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30822 | CRM1 | Exportin-1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSTGASQIV | SALDVIYSPK | SNNSQRQEAQ | KFLDEVKLCS | ESPFWGYEIA | LQNPTNSILK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YFGLGLLDHA | VKKNWNDYDE | GKRVALRKWV | MELNFGVQDY | DTRYIKEKLA | TLWVEVAKRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WGEALKQTNP | TEEQLLTSWV | DMDNNLFELW | NINQSSRELA | LIIFRILFED | VFLLDDLIVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRMTVIQPLC | VMIVCPIEVF | AIKYKFSDKW | TKFKANEEGW | FSVWIPELNN | ALQQNNSEYI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IRLLETLKTC | LNWPLTEVIV | RNDVLSSLLT | CLSSNIPRAQ | SMALDSIHIL | LTRPYSNESH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YQMTIDRVFD | NMDLLDSVYE | SLLFDPTDDI | DETKYPIIKK | FVDMISCLYV | CVPKIKETNG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QIQKYFKLVL | KTTYNPSLIV | SGLTLDLWCT | CLRNDEYLPK | LEKYVIPDLL | QFAADALVYY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EQIDGHISKK | FAEIDFQSKS | EFQTFCSTYR | KRIRDIIRLI | SCVELDLTYD | WLNNRLNNYF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSPFGQQVLS | STFLDHKLEP | YLGALSQYMI | VECFINGCIR | WKIWYPTGDD | YDEKLDSILQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLEILSNQLI | ALNLREPLLL | KKQIQNFALF | LTMLKDNVLF | TLLEKIITSA | TMDYPEINLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ERGAESDAVR | DLRYACGIEL | NRMALLMPES | LKKIYPDLES | VIARIMPNLS | YHEKISFKSF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLIIVLKSSL | DMKEERFAAI | VDPELLAWSD | KTTVVGLSDL | HWFMERLGIV | QIAEYFQRRD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IDENSDLLSI | PIDDEGKELK | SELTKRWQSL | FPVRATRMFI | HYSMQSIKTD | EEFKMLQDLW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RPRIVPILPY | ITRLLYQLQS | YHDPDNWKGL | PTVVQSFVKY | STIERFWEAG | ASNKSKDEFI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DEHMKAMQTL | RDFADSVGHI | IRYTREYTLL | VLSAISSLGS | VFYLLDESPD | LLLNSIAIFK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PGSNEISPGV | STHGWKHIMN | IAIRPILKGC | PKDCLGKFMP | AFLPKLFEIL | DLLLCQKWSS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| HMNDMDMNPV | PTDDDQMTEE | ILEENLLRQL | TTVVVRIVID | CVGQGNANPN | SAKSRLNNHQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| MEMRKIIFND | LNTLAPFLKL | LNHLISFKDT | KCSFNSILVM | KCCLTSVLNQ | NNTVDEYFTF |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EVMKNLLLNV | LCNSAFKDSF | HEALYAFTVI | FLTLCKEYPS | ARAFLFEISN | GYNIDELYRN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LRSVDEYKTQ | RALMIDFIDW | VKSTSGKEDG | NVDHAGDERK | RQEKREAILK | KANERLIKKN |
| 1210 | 1220 | ||||
| KENGDMLDDP | NIEDGAVGNL | FDDN |