Q9SMR2
Gene name |
TFCC (POR, At4g39920, T5J17.90) |
Protein name |
Tubulin-folding cofactor C |
Names |
AtTFCC, TFC C, Protein PORCINO |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G39920 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SMR2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SMR2-F1 | Predicted | AlphaFoldDB |
29 variants for Q9SMR2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02982404 | 6 | Q>K | No | 1000Genomes | |
| tmp_4_18515913_A_G | 11 | E>G | No | 1000Genomes | |
| tmp_4_18515975_C_T | 32 | H>Y | No | 1000Genomes | |
| ENSVATH06856374 | 63 | S>L | No | 1000Genomes | |
| ENSVATH06856375 | 68 | E>D | No | 1000Genomes | |
| tmp_4_18516086_T_A | 69 | S>T | No | 1000Genomes | |
| ENSVATH12514347 | 72 | A>S | No | 1000Genomes | |
| ENSVATH12514347 | 72 | A>T | No | 1000Genomes | |
| ENSVATH12514348 | 98 | D>E | No | 1000Genomes | |
| ENSVATH06856378 | 122 | I>N | No | 1000Genomes | |
| tmp_4_18516275_A_T | 132 | I>F | No | 1000Genomes | |
| tmp_4_18516278_C_G | 133 | L>V | No | 1000Genomes | |
| tmp_4_18516288_A_T | 136 | E>V | No | 1000Genomes | |
| ENSVATH02982407 | 163 | K>T | No | 1000Genomes | |
| tmp_4_18516381_T_A | 167 | V>D | No | 1000Genomes | |
| ENSVATH12514360 | 172 | L>F | No | 1000Genomes | |
| tmp_4_18516399_T_G | 173 | V>G | No | 1000Genomes | |
| ENSVATH06856382 | 194 | E>K | No | 1000Genomes | |
| tmp_4_18516501_A_C | 207 | D>A | No | 1000Genomes | |
| tmp_4_18516536_G_A | 219 | A>T | No | 1000Genomes | |
| ENSVATH06856384 | 229 | S>R | No | 1000Genomes | |
| tmp_4_18516600_T_G | 240 | L>R | No | 1000Genomes | |
| ENSVATH12514362 | 250 | V>I | No | 1000Genomes | |
| ENSVATH12514363 | 263 | K>M | No | 1000Genomes | |
| tmp_4_18516793_G_T | 304 | E>D | No | 1000Genomes | |
| ENSVATH06856385 | 322 | V>A | No | 1000Genomes | |
| tmp_4_18516866_C_T | 329 | L>F | No | 1000Genomes | |
| tmp_4_18516867_T_G | 329 | L>R | No | 1000Genomes | |
| ENSVATH02982408 | 343 | G>E | No | 1000Genomes |
No associated diseases with Q9SMR2
5 regional properties for Q9SMR2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CARP motif | 206 - 243 | IPR006599-1 |
| domain | CARP motif | 244 - 278 | IPR006599-2 |
| domain | Tubulin binding cofactor C-like domain | 200 - 316 | IPR012945 |
| domain | C-CAP/cofactor C-like domain | 169 - 318 | IPR017901 |
| domain | Tubulin-specific chaperone C, N-terminal | 26 - 141 | IPR031925 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| tubulin binding | Binding to monomeric or multimeric forms of tubulin, including microtubules. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| post-chaperonin tubulin folding pathway | Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| tubulin complex assembly | The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDDGQSSVA | ETLDPALQKK | HHDMLERLSA | RHQARKSDSP | DSSSSSSSTL | ESTSSFLAKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDSKRSIESR | IAESRLASSS | TDSSKLKSDL | AEISVAIDNL | EKLLAENSYF | LPSYEVRSSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KIVSDLKQSL | DILSGELVPK | KKFSFKSKST | TKKPESKLPE | IQKPDVVLPP | KLVPVRDSPG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRNKHGETLV | KSFEGSSIGE | FTLSDLDSCQ | VKLTGTVNAL | FLHRLKKCSV | YTGPVIGSIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IDDVEDCVLV | LASHQIRIHC | ARKSDFYLRV | RSRPIIEDSN | GVRFAPYCLD | YKGIDEDLKT |
| 310 | 320 | 330 | 340 | ||
| AGLEEETNNW | ANVDDFRWLR | AVQSPNWSLL | PEEERVSLLT | ISGDS |