Q3SZE9

PR
Gene name
TBCC
Protein name
Tubulin-specific chaperone C
Names
Tubulin-folding cofactor C, CFC
Species
Bos taurus (Bovine)
KEGG Pathway
bta:515354
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SZE9

Entry ID Method Resolution Chain Position Source
AF-Q3SZE9-F1 Predicted AlphaFoldDB

140 variants for Q3SZE9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs800854300 4 G>S No EVA
rs136393526 11 L>P No EVA
rs462376188 15 D>N No EVA
rs442284110 25 V>G No EVA
rs476909673 27 E>A No EVA
rs463278806 33 E>* No EVA
rs439545809 36 R>L No EVA
rs470852850 39 E>A No EVA
rs470852850 39 E>G No EVA
rs454068602 40 V>G No EVA
rs440499998 44 K>Q No EVA
rs474588963 46 K>N No EVA
rs469215811 48 Q>E No EVA
rs452385089 50 Q>K No EVA
rs431945773 51 E>V No EVA
rs466608592 52 V>E No EVA
rs466608592 52 V>G No EVA
rs481140937 53 E>D No EVA
rs446540039 53 E>G No EVA
rs467511685 55 E>G No EVA
rs448548231 57 S>R No EVA
rs483248370 58 D>H No EVA
rs463213471 59 F>L No EVA
rs439904388 60 F>L No EVA
rs439904388 60 F>V No EVA
rs477194672 62 A>P No EVA
rs440389151 63 A>G No EVA
rs460405987 63 A>T No EVA
rs474877333 64 F>L No EVA
rs455031405 65 A>S No EVA
rs444147894 66 R>W No EVA
rs475694570 67 E>Q No EVA
rs452306478 67 E>V No EVA
rs466545315 70 A>D No EVA
rs435989318 71 V>A No EVA
rs450567931 72 E>D No EVA
rs483260517 73 E>* No EVA
rs469636215 73 E>D No EVA
rs446281936 74 L>F No EVA
rs477478894 77 S>C No EVA
rs460699674 79 E>A No EVA
rs460699674 79 E>V No EVA
rs440324144 80 S>P No EVA
rs461407157 85 E>G No EVA
rs461407157 85 E>V No EVA
rs444563908 86 E>G No EVA
rs475589629 87 A>G No EVA
rs473258499 88 A>D No EVA
rs473258499 88 A>G No EVA
rs438638398 88 A>P No EVA
rs438638398 88 A>S No EVA
rs453235777 89 A>V No EVA
rs473869919 90 R>L No EVA
rs456962012 91 L>V No EVA
rs465047178 92 Q>H No EVA
rs436918975 92 Q>P No EVA
rs436918975 92 Q>R No EVA
rs432561879 94 L>P No EVA
rs467057549 95 Q>P No EVA
rs467057549 95 Q>R No EVA
rs447152167 96 K>N No EVA
rs481465984 101 S>A No EVA
rs481465984 101 S>P No EVA
rs450871704 102 V>D No EVA
rs482340424 104 F>S No EVA
rs482340424 104 F>Y No EVA
rs459048291 106 A>D No EVA
rs459048291 106 A>V No EVA
rs438575090 112 Q>P No EVA
rs473197203 113 A>E No EVA
rs442747023 115 E>D No EVA
rs473781139 116 V>G No EVA
rs456893287 118 A>P No EVA
rs436795935 120 L>P No EVA
rs471465065 121 Q>E No EVA
rs451303525 121 Q>P No EVA
rs432551451 127 R>G No EVA
rs447084690 132 Q>E No EVA
rs468066144 139 F>L No EVA
rs450833757 141 T>P No EVA
rs465418002 143 K>Q No EVA
rs445405734 144 K>Q No EVA
rs479591892 150 T>M No EVA
rs442615739 157 D>N No EVA
rs471258632 162 E>A No EVA
rs451292954 162 E>D No EVA
rs473380111 163 G>A No EVA
rs440898996 163 G>C No EVA
rs453450324 164 S>I No EVA
rs436595582 166 T>A No EVA
rs457567134 169 P>A No EVA
rs437184880 170 P>R No EVA
rs465404127 172 K>* No EVA
rs445336173 172 K>R No EVA
rs479882096 173 E>G No EVA
rs449031368 174 E>A No EVA
rs466283607 174 E>Q No EVA
rs480479503 176 D>G No EVA
rs443541235 177 F>L No EVA
rs477593333 178 D>G No EVA
rs440786353 179 S>F No EVA
rs457602964 179 S>P No EVA
rs472066947 184 G>R No EVA
rs433062812 186 S>F No EVA
rs474459670 187 N>S No EVA
rs457630883 188 L>M No EVA
rs437519752 189 Q>E No EVA
rs465687759 191 Q>R No EVA
rs434782435 194 E>V No EVA
rs449343144 200 L>R No EVA
rs435368010 205 V>L No EVA
rs470005134 206 L>I No EVA
rs449942223 207 L>S No EVA
rs477877192 210 L>P No EVA
rs447160383 211 R>T No EVA
rs478413067 212 N>I No EVA
rs461852158 214 T>A No EVA
rs441732867 214 T>K No EVA
rs463895730 216 K>T No EVA
rs472048136 217 L>I No EVA
rs434771736 218 Y>* No EVA
rs452029732 218 Y>S No EVA
rs455806201 219 G>D No EVA
rs472621930 219 G>R No EVA
rs472621930 219 G>S No EVA
rs455806201 219 G>V No EVA
rs470316770 221 P>R No EVA
rs449755523 223 T>P No EVA
rs432954646 224 L>V No EVA
rs447543389 227 T>P No EVA
rs478402502 228 K>Q No EVA
rs482752527 241 T>P No EVA
rs482752527 241 T>S No EVA
rs443797636 243 V>M No EVA
rs472037463 249 S>C No EVA
rs458422087 250 D>V No EVA
rs472615993 257 C>G No EVA
rs435590447 269 R>L No EVA
rs476681783 274 V>E No EVA
rs456476124 329 S>Y No EVA

No associated diseases with Q3SZE9

5 regional properties for Q3SZE9

Type Name Position InterPro Accession
domain CARP motif 210 - 247 IPR006599-1
domain CARP motif 248 - 282 IPR006599-2
domain Tubulin binding cofactor C-like domain 203 - 320 IPR012945
domain C-CAP/cofactor C-like domain 170 - 322 IPR017901
domain Tubulin-specific chaperone C, N-terminal 27 - 135 IPR031925

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Detected predominantly in the photoreceptor connecting cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
photoreceptor connecting cilium The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.

2 GO annotations of molecular function

Name Definition
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules.

3 GO annotations of biological process

Name Definition
post-chaperonin tubulin folding pathway Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15814 TBCC Tubulin-specific chaperone C Homo sapiens (Human) PR
Q8VCN9 Tbcc Tubulin-specific chaperone C Mus musculus (Mouse) PR
Q9SMR2 TFCC Tubulin-folding cofactor C Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
METGGLSAAA LANGDLGSQR ERTLVPERLQ KREHERQLEV ERRKQKRQDQ EVEEEKSDFF
70 80 90 100 110 120
AAAFARERSA VEELLESGES VERLEEAAAR LQGLQKLIND SVLFLAAYDL RQAQEVLARL
130 140 150 160 170 180
QAALAKRRQE LQPKKRFAFK TRKKDAASAT QVASAPDAPA AEGSLTSPPP LKEEGDFDSS
190 200 210 220 230 240
WICGFSNLQS QVLEKRAEEL HQQDVLLTQL RNCTIKLYGN PNTLRLTKAQ GCTLLCGPVS
250 260 270 280 290 300
TSVFLEDCSD CVLAVACQQL RVHTTKDTRI FLQVTSRAIM EDCTGIQFAP YTWSYPGIDK
310 320 330 340
DFEGSGLDKN KNNWNDVDDF NWLARDVASP NWNVLPEEER RIQWD