Q8VCN9

PR
Gene name
Tbcc
Protein name
Tubulin-specific chaperone C
Names
Paired immunoglobin-like type 2 receptor-ligand, PILR-L, Tubulin-folding cofactor C, CFC
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72726
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VCN9

Entry ID Method Resolution Chain Position Source
AF-Q8VCN9-F1 Predicted AlphaFoldDB

No variants for Q8VCN9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8VCN9

No associated diseases with Q8VCN9

5 regional properties for Q8VCN9

Type Name Position InterPro Accession
domain CARP motif 206 - 243 IPR006599-1
domain CARP motif 244 - 278 IPR006599-2
domain Tubulin binding cofactor C-like domain 199 - 316 IPR012945
domain C-CAP/cofactor C-like domain 163 - 318 IPR017901
domain Tubulin-specific chaperone C, N-terminal 26 - 134 IPR031925

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Detected predominantly in the photoreceptor connecting cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
photoreceptor connecting cilium The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.

2 GO annotations of molecular function

Name Definition
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules.

3 GO annotations of biological process

Name Definition
post-chaperonin tubulin folding pathway Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZE9 TBCC Tubulin-specific chaperone C Bos taurus (Bovine) PR
Q15814 TBCC Tubulin-specific chaperone C Homo sapiens (Human) PR
Q9SMR2 TFCC Tubulin-folding cofactor C Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEGVDCSMAL ADAAAGSPRD LSLVPERLQR REQERQIEVE RRKQKRQDQE VEEEKSGFFA
70 80 90 100 110 120
AAFARERAAV EELLRGEASA ERLEEAANRL QGLRKLLNDS VLFLAAYDLR QGQAALAQLQ
130 140 150 160 170 180
AVLTERRQEL QPKKRFAFKA RKKDAAGTAQ VDAAPVTSAA PSPPVTKEEE GAPGASWACG
190 200 210 220 230 240
FSNLESQDLE KRAEELHQRD VLLSDLTNCT VKLCGNPNTL RLAKARGCKV LCGPVTTSVF
250 260 270 280 290 300
LEDCRDCVLA VACQQLRVHT TKDTRVFLQV TSRAIVEDCS GIQFAPYTWS YPGIDKDFQD
310 320 330 340
SGLDRSKNNW DQVDDFNWLA RNVASPNWSI LPEEERDIQW D