Q9SLC6
PR
Gene name |
STIPL2 (At2g42330) |
Protein name |
Septin and tuftelin-interacting protein 1 homolog 2 |
Names |
Protein SPLICEOSOMAL TIMEKEEPER LOCUS 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G42330 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SLC6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SLC6-F1 | Predicted | AlphaFoldDB |
106 variants for Q9SLC6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13617332 | 6 | K>N | No | 1000Genomes | |
| ENSVATH05702889 | 8 | E>K | No | 1000Genomes | |
| ENSVATH05702888 | 11 | R>K | No | 1000Genomes | |
| ENSVATH01980543 | 26 | D>G | No | 1000Genomes | |
| ENSVATH05702887 | 41 | R>H | No | 1000Genomes | |
| ENSVATH05702886 | 58 | L>P | No | 1000Genomes | |
| ENSVATH13617331 | 62 | R>G | No | 1000Genomes | |
| ENSVATH00270970 | 65 | C>S | No | 1000Genomes | |
| tmp_2_17633873_T_C | 73 | T>A | No | 1000Genomes | |
| tmp_2_17633836_T_C | 85 | D>G | No | 1000Genomes | |
| tmp_2_17633832_C_A | 86 | K>N | No | 1000Genomes | |
| ENSVATH05702885 | 93 | N>K | No | 1000Genomes | |
| tmp_2_17633809_T_C | 94 | N>S | No | 1000Genomes | |
| ENSVATH05702884 | 95 | K>N | No | 1000Genomes | |
| ENSVATH05702883 | 96 | K>E | No | 1000Genomes | |
| ENSVATH05702882 | 98 | N>H | No | 1000Genomes | |
| tmp_2_17633796_G_C | 98 | N>K | No | 1000Genomes | |
| tmp_2_17633779_C_A,T | 104 | G>E | No | 1000Genomes | |
| tmp_2_17633779_C_A,T | 104 | G>V | No | 1000Genomes | |
| ENSVATH05702881 | 112 | E>K | No | 1000Genomes | |
| tmp_2_17633739_T_G | 117 | K>N | No | 1000Genomes | |
| ENSVATH05702880 | 118 | G>E | No | 1000Genomes | |
| ENSVATH05702879 | 119 | R>G | No | 1000Genomes | |
| ENSVATH00270969 | 130 | A>S | No | 1000Genomes | |
| ENSVATH05702876 | 152 | N>S | No | 1000Genomes | |
| ENSVATH05702875 | 156 | F>L | No | 1000Genomes | |
| ENSVATH05702874 | 158 | C>G | No | 1000Genomes | |
| tmp_2_17633608_T_G | 161 | K>T | No | 1000Genomes | |
| ENSVATH05702873 | 162 | V>F | No | 1000Genomes | |
| ENSVATH05702872 | 165 | K>E | No | 1000Genomes | |
| tmp_2_17633588_T_C | 168 | S>G | No | 1000Genomes | |
| ENSVATH01980542 | 173 | V>F | No | 1000Genomes | |
| ENSVATH01980542 | 173 | V>L | No | 1000Genomes | |
| tmp_2_17633569_C_T | 174 | S>N | No | 1000Genomes | |
| ENSVATH00270966 | 178 | G>C | No | 1000Genomes | |
| ENSVATH05702871 | 183 | D>N | No | 1000Genomes | |
| tmp_2_17633534_T_C | 186 | K>E | No | 1000Genomes | |
| ENSVATH05702869 | 193 | E>D | No | 1000Genomes | |
| ENSVATH05702868 | 194 | V>F | No | 1000Genomes | |
| ENSVATH05702867 | 195 | Y>S | No | 1000Genomes | |
| ENSVATH05702866 | 202 | L>V | No | 1000Genomes | |
| ENSVATH05702863 | 215 | L>I | No | 1000Genomes | |
| ENSVATH05702862 | 215 | L>P | No | 1000Genomes | |
| ENSVATH00270965 | 228 | N>K | No | 1000Genomes | |
| ENSVATH05702860 | 243 | N>K | No | 1000Genomes | |
| ENSVATH00270964 | 245 | Q>P | No | 1000Genomes | |
| tmp_2_17633312_G_A | 260 | L>F | No | 1000Genomes | |
| tmp_2_17633266_T_G | 275 | K>T | No | 1000Genomes | |
| tmp_2_17633238_C_A | 284 | E>D | No | 1000Genomes | |
| ENSVATH05702858 | 291 | G>R | No | 1000Genomes | |
| ENSVATH05702857 | 292 | V>E | No | 1000Genomes | |
| ENSVATH05702856 | 296 | K>T | No | 1000Genomes | |
| ENSVATH05702855 | 305 | V>I | No | 1000Genomes | |
| tmp_2_17633162_C_T | 310 | D>N | No | 1000Genomes | |
| ENSVATH14608322 | 310 | D>V | No | 1000Genomes | |
| ENSVATH00270963 | 317 | A>V | No | 1000Genomes | |
| ENSVATH05702854 | 322 | T>S | No | 1000Genomes | |
| ENSVATH13617330 | 328 | N>D | No | 1000Genomes | |
| ENSVATH13617329 | 340 | D>Y | No | 1000Genomes | |
| tmp_2_17633025_C_A | 355 | L>F | No | 1000Genomes | |
| ENSVATH05702853 | 357 | L>I | No | 1000Genomes | |
| ENSVATH14608321 | 358 | F>Y | No | 1000Genomes | |
| tmp_2_17633000_C_T | 364 | G>S | No | 1000Genomes | |
| tmp_2_17632912_A_G | 393 | I>T | No | 1000Genomes | |
| tmp_2_17632894_T_G | 399 | Q>P | No | 1000Genomes | |
| ENSVATH05702851 | 406 | L>V | No | 1000Genomes | |
| ENSVATH00270962 | 413 | G>C | No | 1000Genomes | |
| tmp_2_17632757_A_T | 445 | L>M | No | 1000Genomes | |
| ENSVATH00270960 | 455 | I>T | No | 1000Genomes | |
| ENSVATH00270959 | 463 | R>C | No | 1000Genomes | |
| ENSVATH00270958 | 463 | R>H | No | 1000Genomes | |
| ENSVATH05702848 | 471 | F>V | No | 1000Genomes | |
| tmp_2_17632666_G_T | 475 | P>Q | No | 1000Genomes | |
| tmp_2_17632654_A_T | 479 | V>E | No | 1000Genomes | |
| ENSVATH05702846 | 479 | V>I | No | 1000Genomes | |
| tmp_2_17632638_C_A | 484 | L>F | No | 1000Genomes | |
| ENSVATH05702844 | 488 | Y>S | No | 1000Genomes | |
| ENSVATH05702843 | 489 | Q>E | No | 1000Genomes | |
| tmp_2_17632616_G_A | 492 | R>* | No | 1000Genomes | |
| ENSVATH05702842 | 492 | R>Q | No | 1000Genomes | |
| ENSVATH00270955 | 501 | A>S | No | 1000Genomes | |
| ENSVATH00270955 | 501 | A>T | No | 1000Genomes | |
| ENSVATH05702839 | 531 | R>S | No | 1000Genomes | |
| ENSVATH14608319 | 534 | V>I | No | 1000Genomes | |
| ENSVATH14608318 | 535 | P>L | No | 1000Genomes | |
| ENSVATH00270954 | 539 | V>L | No | 1000Genomes | |
| ENSVATH00270952 | 544 | F>I | No | 1000Genomes | |
| ENSVATH05702837 | 555 | E>Q | No | 1000Genomes | |
| ENSVATH01980540 | 561 | G>E | No | 1000Genomes | |
| tmp_2_17632404_C_T | 562 | W>* | No | 1000Genomes | |
| ENSVATH14608317 | 586 | V>I | No | 1000Genomes | |
| ENSVATH00270950 | 622 | E>G | No | 1000Genomes | |
| tmp_2_17632201_T_C | 630 | D>G | No | 1000Genomes | |
| tmp_2_17632177_C_T | 638 | R>Q | No | 1000Genomes | |
| tmp_2_17632163_G_T | 643 | Q>K | No | 1000Genomes | |
| tmp_2_17632100_G_C | 664 | R>G | No | 1000Genomes | |
| ENSVATH05702833 | 667 | V>A | No | 1000Genomes | |
| ENSVATH05702832 | 673 | D>G | No | 1000Genomes | |
| ENSVATH14608316 | 697 | K>* | No | 1000Genomes | |
| ENSVATH13617302 | 699 | H>N | No | 1000Genomes | |
| tmp_2_17631973_T_C | 706 | Q>R | No | 1000Genomes | |
| ENSVATH13617301 | 709 | R>T | No | 1000Genomes | |
| tmp_2_17631960_G_C,A | 710 | F>L | No | 1000Genomes | |
| ENSVATH00270946 | 729 | E>A | No | 1000Genomes | |
| ENSVATH00270945 | 749 | T>A | No | 1000Genomes | |
| tmp_2_17631841_C_A | 750 | G>V | No | 1000Genomes |
No associated diseases with Q9SLC6
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| U2-type post-mRNA release spliceosomal complex | A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of auxin biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. |
| spliceosomal complex disassembly | Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06411 | SPP382 | Pre-mRNA-splicing factor SPP382 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9UBB9 | TFIP11 | Tuftelin-interacting protein 11 | Homo sapiens (Human) | PR |
| Q9ERA6 | Tfip11 | Tuftelin-interacting protein 11 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDEGKKEKR | RQTKEDAVYG | FVFESDSNSD | DSGGSRRKKR | RKTKPVKFSS | AGNIDQVLKQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRGNCKIDEN | DDTILPIALG | KKIADKAHVR | EKNNKKENFE | KFSGGIGMKL | LEKMGYKGRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LGKNQQGIVA | PIEVQLRPKN | MGMGYNDFKE | KNAPLFPCLN | KVEEKKKSVV | VTVSENHGDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RRDLWKKKNV | RKEVYITAEE | FLGKKQEEGF | GCDQLIIDKR | GPQDRVVNSL | RNLYAEEKAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DANVQQPELQ | HNLRFIVKSL | EHGILKTDKD | LRNEKGLALS | LQQEKEKFKM | GVKKQKTLFD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLGYVAEEID | RIEVEIASGN | LTLDSLANRF | KDLRSSYPDD | YKCCNLSCIA | SSLALPLFIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MFQGWDPLSD | AEHGIEAISS | WKMLLEVEDN | QSISTPYSQL | VSEVILPAVR | VSGINTWEPR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPEPMLRLLE | TWEKMLPSLI | FETILTTVVL | PKLSIAIESW | EPRLETVPIH | FWVHPWLPVL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GQKLESAYQI | IRMKFGNLLD | AWHPSDVSVH | TILSPWKTVF | DAASWEQLMR | RYIVPKLQVA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LQEFQINPAD | QNLDEFNLVM | GWVSSVPIHL | MTDLMERFFF | PKWLDVLYHW | LCSEPKFDEI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MKWFLGWKGT | FPQELSANRR | IEIQFKRGLD | MAREAVERME | MSQPGARENI | SYHKAQEQRQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SEGRAKVQAQ | VDDPEELSFK | EAVELFAQEK | ELLLKPKPHR | MHNGLQIYRF | GNVSVLLDSA |
| 730 | 740 | 750 | |||
| NSKLLAQEEG | RWFPVDLDSL | LKMHYSAVTG | KQ |