Q9SL67

PR
Gene name
RPT2B
Protein name
26S proteasome regulatory subunit 4 homolog B
Names
26S proteasome AAA-ATPase subunit RPT2b, 26S proteasome subunit 4 homolog B, Regulatory particle triple-A ATPase subunit 2b
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G20140
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SL67

Entry ID Method Resolution Chain Position Source
AF-Q9SL67-F1 Predicted AlphaFoldDB

11 variants for Q9SL67

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01850142 10 N>H No 1000Genomes
ENSVATH05539446 17 P>T No 1000Genomes
tmp_2_8692809_A_G 25 K>R No 1000Genomes
ENSVATH13294660 38 R>K No 1000Genomes
tmp_2_8692922_C_G 63 L>V No 1000Genomes
tmp_2_8692946_A_G 71 I>V No 1000Genomes
ENSVATH13294661 75 L>F No 1000Genomes
ENSVATH13294662 94 K>R No 1000Genomes
tmp_2_8693369_A_T 185 E>V No 1000Genomes
ENSVATH05539449 221 P>A No 1000Genomes
tmp_2_8694549_A_C 379 E>D No 1000Genomes

No associated diseases with Q9SL67

5 regional properties for Q9SL67

Type Name Position InterPro Accession
domain AAA+ ATPase domain 221 - 360 IPR003593
domain ATPase, AAA-type, core 225 - 358 IPR003959
conserved_site ATPase, AAA-type, conserved site 328 - 346 IPR003960
domain Proteasomal ATPase OB C-terminal domain 112 - 166 IPR032501
domain AAA ATPase, AAA+ lid domain 380 - 423 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

4 GO annotations of biological process

Name Definition
female gamete generation Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
maintenance of root meristem identity The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
male gamete generation Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40327 RPT2 26S proteasome regulatory subunit 4 homolog Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P46466 TBP2 26S proteasome regulatory subunit 4 homolog Oryza sativa subsp japonica (Rice) PR
Q9SZD4 RPT2A 26S proteasome regulatory subunit 4 homolog A Arabidopsis thaliana (Mouse-ear cress) PR
Q9SEI2 RPT5A 26S proteasome regulatory subunit 6A homolog A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGQGPSGGLN RQGDRKPDGG EKKEKKFEPA APPARVGRKQ RKQKGPEAAA RLPTVTPSTK
70 80 90 100 110 120
CKLRLLKLER IKDYLLMEEE FVANQERLKP QEEKAEEDRS KVDDLRGTPM SVGNLEELID
130 140 150 160 170 180
ENHAIVSSSV GPEYYVGILS FVDKDQLEPG CSILMHNKVL SVVGILQDEV DPMVSVMKVE
190 200 210 220 230 240
KAPLESYADI GGLEAQIQEI KEAVELPLTH PELYEDIGIK PPKGVILYGE PGTGKTLLAK
250 260 270 280 290 300
AVANSTSATF LRVVGSELIQ KYLGDGPKLV RELFRVADDL SPSIVFIDEI DAVGTKRYDA
310 320 330 340 350 360
NSGGEREIQR TMLELLNQLD GFDSRGDVKV ILATNRIESL DPALLRPGRI DRKIEFPLPD
370 380 390 400 410 420
IKTRRRIFQI HTSKMTLAED VNLEEFVMTK DEFSGADIKA ICTEAGLLAL RERRMKVTHV
430 440
DFKKAKEKVM FKKKEGVPEG LYM