Q9SHF3
PR
Gene name |
AGO2 (At1g31280, T19E23.7) |
Protein name |
Protein argonaute 2 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G31280 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9SHF3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4G0M | X-ray | 231 A | A/B | 579-727 | PDB |
| AF-Q9SHF3-F1 | Predicted | AlphaFoldDB |
165 variants for Q9SHF3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12501878 | 3 | R>G | No | 1000Genomes | |
| ENSVATH12501879 | 3 | R>I | No | 1000Genomes | |
| ENSVATH12501880 | 7 | R>Q | No | 1000Genomes | |
| ENSVATH01138974 | 13 | G>V | No | 1000Genomes | |
| tmp_1_11181820_G_T | 15 | G>V | No | 1000Genomes | |
| ENSVATH04687568 | 18 | G>D | No | 1000Genomes | |
| ENSVATH01138976 | 18 | G>S | No | 1000Genomes | |
| ENSVATH09313102 | 25 | G>R | No | 1000Genomes | |
| ENSVATH04687570 | 27 | G>E | No | 1000Genomes | |
| ENSVATH12501923 | 28 | G>E | No | 1000Genomes | |
| ENSVATH01138978 | 33 | D>G | No | 1000Genomes | |
| ENSVATH04687571 | 34 | R>C | No | 1000Genomes | |
| tmp_1_11181886_G_A | 37 | G>D | No | 1000Genomes | |
| tmp_1_11181885_G_A | 37 | G>S | No | 1000Genomes | |
| ENSVATH01138979 | 43 | R>L | No | 1000Genomes | |
| ENSVATH12501999 | 47 | S>P | No | 1000Genomes | |
| ENSVATH04687573 | 52 | G>E | No | 1000Genomes | |
| tmp_1_11181943_A_T | 56 | Q>L | No | 1000Genomes | |
| ENSVATH14024546 | 67 | Q>K | No | 1000Genomes | |
| ENSVATH04687575 | 70 | R>W | No | 1000Genomes | |
| tmp_1_11181991_C_T | 72 | P>L | No | 1000Genomes | |
| tmp_1_11182002_C_T | 76 | H>Y | No | 1000Genomes | |
| tmp_1_11182029_C_G | 85 | Q>E | No | 1000Genomes | |
| ENSVATH12502001 | 87 | P>S | No | 1000Genomes | |
| ENSVATH04687578 | 89 | P>T | No | 1000Genomes | |
| tmp_1_11182046_G_T | 90 | Q>H | No | 1000Genomes | |
| ENSVATH04687580 | 92 | A>T | No | 1000Genomes | |
| ENSVATH04687581 | 93 | P>L | No | 1000Genomes | |
| tmp_1_11182074_G_T | 100 | A>S | No | 1000Genomes | |
| tmp_1_11182075_C_T | 100 | A>V | No | 1000Genomes | |
| tmp_1_11182078_G_T | 101 | S>I | No | 1000Genomes | |
| tmp_1_11182077_A_C | 101 | S>R | No | 1000Genomes | |
| tmp_1_11182096_G_A | 107 | G>E | No | 1000Genomes | |
| tmp_1_11182099_G_A | 108 | G>E | No | 1000Genomes | |
| ENSVATH01138982 | 110 | A>D | No | 1000Genomes | |
| tmp_1_11182107_G_A | 111 | G>S | No | 1000Genomes | |
| tmp_1_11182111_G_A | 112 | R>K | No | 1000Genomes | |
| ENSVATH04687582 | 114 | A>V | No | 1000Genomes | |
| tmp_1_11182125_C_T | 117 | R>C | No | 1000Genomes | |
| ENSVATH01138983 | 120 | Q>H | No | 1000Genomes | |
| tmp_1_11182135_A_T | 120 | Q>L | No | 1000Genomes | |
| ENSVATH04687583 | 121 | V>F | No | 1000Genomes | |
| tmp_1_11182141_C_T | 122 | P>L | No | 1000Genomes | |
| ENSVATH04687584 | 126 | A>P | No | 1000Genomes | |
| ENSVATH04687584 | 126 | A>T | No | 1000Genomes | |
| tmp_1_11182155_T_A | 127 | S>T | No | 1000Genomes | |
| ENSVATH01138984 | 128 | P>L | No | 1000Genomes | |
| ENSVATH01138985 | 131 | S>T | No | 1000Genomes | |
| ENSVATH00054343 | 132 | T>I | No | 1000Genomes | |
| tmp_1_11182182_T_C | 136 | S>P | No | 1000Genomes | |
| tmp_1_11182185_G_A | 137 | E>K | No | 1000Genomes | |
| ENSVATH04687586 | 138 | P>A | No | 1000Genomes | |
| ENSVATH14024551 | 143 | E>K | No | 1000Genomes | |
| tmp_1_11182475_C_T | 165 | P>S | No | 1000Genomes | |
| tmp_1_11182502_C_T | 174 | R>W | No | 1000Genomes | |
| ENSVATH04687594 | 183 | Y>F | No | 1000Genomes | |
| tmp_1_11182534_A_T | 184 | K>N | No | 1000Genomes | |
| tmp_1_11182596_C_T | 205 | P>L | No | 1000Genomes | |
| ENSVATH04687595 | 209 | V>I | No | 1000Genomes | |
| ENSVATH04687597 | 221 | V>M | No | 1000Genomes | |
| ENSVATH04687598 | 233 | M>R | No | 1000Genomes | |
| ENSVATH00054348 | 246 | V>A | No | 1000Genomes | |
| ENSVATH04687600 | 247 | E>K | No | 1000Genomes | |
| ENSVATH04687601 | 247 | E>V | No | 1000Genomes | |
| ENSVATH00054350 | 257 | Y>F | No | 1000Genomes | |
| tmp_1_11182755_C_T | 258 | P>L | No | 1000Genomes | |
| ENSVATH04687603 | 266 | R>Q | No | 1000Genomes | |
| ENSVATH00054351 | 271 | T>S | No | 1000Genomes | |
| ENSVATH12502054 | 277 | V>A | No | 1000Genomes | |
| tmp_1_11182823_G_A | 281 | G>S | No | 1000Genomes | |
| tmp_1_11182833_A_T | 284 | K>I | No | 1000Genomes | |
| tmp_1_11182844_A_G | 288 | T>A | No | 1000Genomes | |
| tmp_1_11182848_G_A | 289 | G>E | No | 1000Genomes | |
| tmp_1_11182869_G_T | 296 | R>L | No | 1000Genomes | |
| ENSVATH00054354 | 312 | K>R | No | 1000Genomes | |
| ENSVATH14024554 | 327 | E>D | No | 1000Genomes | |
| ENSVATH12502136 | 337 | I>V | No | 1000Genomes | |
| ENSVATH04687606 | 360 | S>L | No | 1000Genomes | |
| tmp_1_11183082_C_A | 367 | A>E | No | 1000Genomes | |
| tmp_1_11183088_C_T | 369 | S>L | No | 1000Genomes | |
| tmp_1_11183148_G_A | 389 | R>H | No | 1000Genomes | |
| tmp_1_11183153_G_T | 391 | V>L | No | 1000Genomes | |
| tmp_1_11183163_A_T | 394 | E>V | No | 1000Genomes | |
| tmp_1_11183184_C_G | 401 | T>S | No | 1000Genomes | |
| ENSVATH12502138 | 412 | T>P | No | 1000Genomes | |
| tmp_1_11183256_A_G | 425 | K>R | No | 1000Genomes | |
| ENSVATH01138992 | 430 | D>E | No | 1000Genomes | |
| ENSVATH04687608 | 432 | E>D | No | 1000Genomes | |
| ENSVATH04687609 | 433 | G>R | No | 1000Genomes | |
| ENSVATH04687610 | 435 | E>K | No | 1000Genomes | |
| tmp_1_11183330_T_C | 450 | Y>H | No | 1000Genomes | |
| ENSVATH00054357 | 453 | H>D | No | 1000Genomes | |
| ENSVATH04687611 | 453 | H>Q | No | 1000Genomes | |
| tmp_1_11183370_A_G | 463 | D>G | No | 1000Genomes | |
| ENSVATH12502140 | 489 | D>E | No | 1000Genomes | |
| ENSVATH04687612 | 504 | L>V | No | 1000Genomes | |
| tmp_1_11183515_G_T | 511 | Q>H | No | 1000Genomes | |
| tmp_1_11183516_A_G | 512 | R>G | No | 1000Genomes | |
| tmp_1_11183517_G_T | 512 | R>M | No | 1000Genomes | |
| tmp_1_11183525_G_A | 515 | D>N | No | 1000Genomes | |
| tmp_1_11183544_G_A | 521 | R>H | No | 1000Genomes | |
| tmp_1_11183557_C_A | 525 | S>R | No | 1000Genomes | |
| tmp_1_11183659_G_C | 531 | G>A | No | 1000Genomes | |
| ENSVATH14024586 | 533 | F>Y | No | 1000Genomes | |
| tmp_1_11183685_A_G | 540 | N>D | No | 1000Genomes | |
| ENSVATH01139002 | 543 | P>L | No | 1000Genomes | |
| tmp_1_11183694_C_A | 543 | P>T | No | 1000Genomes | |
| ENSVATH04687618 | 559 | R>K | No | 1000Genomes | |
| ENSVATH00054362 | 562 | V>A | No | 1000Genomes | |
| ENSVATH04687620 | 562 | V>F | No | 1000Genomes | |
| ENSVATH04687621 | 569 | P>L | No | 1000Genomes | |
| tmp_1_11183804_G_C | 579 | K>N | No | 1000Genomes | |
| ENSVATH01139006 | 588 | V>I | No | 1000Genomes | |
| ENSVATH04687622 | 589 | K>Q | No | 1000Genomes | |
| ENSVATH04687623 | 592 | A>V | No | 1000Genomes | |
| ENSVATH01139010 | 623 | Q>K | No | 1000Genomes | |
| ENSVATH01139012 | 640 | N>K | No | 1000Genomes | |
| ENSVATH01139014 | 644 | I>L | No | 1000Genomes | |
| ENSVATH01139016 | 661 | G>E | No | 1000Genomes | |
| tmp_1_11184084_C_T | 673 | R>W | No | 1000Genomes | |
| ENSVATH01139017 | 674 | K>Q | No | 1000Genomes | |
| ENSVATH04687626 | 681 | L>M | No | 1000Genomes | |
| tmp_1_11184118_T_A | 684 | I>K | No | 1000Genomes | |
| ENSVATH04687627 | 702 | T>I | No | 1000Genomes | |
| ENSVATH04687629 | 709 | R>L | No | 1000Genomes | |
| ENSVATH04687628 | 709 | R>W | No | 1000Genomes | |
| tmp_1_11184252_G_A | 729 | D>N | No | 1000Genomes | |
| ENSVATH04687632 | 738 | D>N | No | 1000Genomes | |
| tmp_1_11184324_C_T | 753 | R>W | No | 1000Genomes | |
| tmp_1_11184333_A_G | 756 | M>V | No | 1000Genomes | |
| tmp_1_11184339_C_T | 758 | P>S | No | 1000Genomes | |
| tmp_1_11184354_G_A | 763 | V>I | No | 1000Genomes | |
| ENSVATH01139021 | 764 | V>M | No | 1000Genomes | |
| ENSVATH04687634 | 774 | R>C | No | 1000Genomes | |
| tmp_1_11184417_C_T | 784 | H>Y | No | 1000Genomes | |
| tmp_1_11184460_A_T | 798 | E>V | No | 1000Genomes | |
| ENSVATH00054365 | 805 | Q>H | No | 1000Genomes | |
| tmp_1_11184538_C_G | 824 | A>G | No | 1000Genomes | |
| ENSVATH12502144 | 831 | N>K | No | 1000Genomes | |
| tmp_1_11184576_G_A | 837 | V>I | No | 1000Genomes | |
| tmp_1_11184601_G_A | 845 | G>D | No | 1000Genomes | |
| ENSVATH12502355 | 845 | G>R | No | 1000Genomes | |
| ENSVATH04687635 | 847 | N>S | No | 1000Genomes | |
| ENSVATH14024589 | 851 | T>M | No | 1000Genomes | |
| ENSVATH12502356 | 863 | F>L | No | 1000Genomes | |
| ENSVATH01139023 | 901 | H>P | No | 1000Genomes | |
| ENSVATH14024590 | 906 | T>A | No | 1000Genomes | |
| ENSVATH12502359 | 914 | T>I | No | 1000Genomes | |
| tmp_1_11184815_G_C | 916 | W>C | No | 1000Genomes | |
| tmp_1_11184821_A_T | 918 | E>D | No | 1000Genomes | |
| ENSVATH14024592 | 926 | V>L | No | 1000Genomes | |
| ENSVATH04687636 | 955 | M>V | No | 1000Genomes | |
| tmp_1_11184955_A_C | 963 | Y>S | No | 1000Genomes | |
| ENSVATH04687637 | 964 | H>Y | No | 1000Genomes | |
| ENSVATH01139025 | 968 | S>F | No | 1000Genomes | |
| tmp_1_11184969_T_C | 968 | S>P | No | 1000Genomes | |
| tmp_1_11184986_T_A | 973 | F>L | No | 1000Genomes | |
| ENSVATH12502360 | 974 | K>R | No | 1000Genomes | |
| ENSVATH14024593 | 976 | P>L | No | 1000Genomes | |
| ENSVATH00054371 | 977 | R>Q | No | 1000Genomes | |
| ENSVATH04687638 | 977 | R>W | No | 1000Genomes | |
| ENSVATH04687639 | 980 | S>* | No | 1000Genomes | |
| ENSVATH00054372 | 983 | A>P | No | 1000Genomes | |
| ENSVATH12502362 | 987 | A>T | No | 1000Genomes | |
| ENSVATH04687640 | 1007 | L>I | No | 1000Genomes |
No associated diseases with Q9SHF3
6 regional properties for Q9SHF3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PAZ domain | 368 - 505 | IPR003100 |
| domain | Piwi domain | 666 - 965 | IPR003165 |
| domain | Argonaute, linker 1 domain | 315 - 367 | IPR014811 |
| domain | Argonaute linker 2 domain | 509 - 555 | IPR032472 |
| domain | Protein argonaute, N-terminal | 174 - 306 | IPR032474 |
| domain | Argonaute-like, PIWI domain | 528 - 963 | IPR045246 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| endoribonuclease activity | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| siRNA binding | Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| modulation by virus of host process | The process in which a virus effects a change in the structure or processes of its host organism. |
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERGGYRGGR | GDGRGRGGRG | YGGGGGGGEQ | GRDRGYGGGE | QGRGRGSERG | GGNRGQGRGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QQDFRSQSQR | GPPPGHGGRG | TTQFQQPRPQ | VAPQPSQAPA | SYAGSVGGVA | GRGAWGRKPQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPSDSASPST | STTVVSEPVR | VAEVMNLKPS | VQVATSDRKE | PMKRPDRGGV | VAVRRVNLYV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NHYKVNFNPE | SVIRHYDVEI | KGEIPTKKVS | RFELAMVRDK | VFTDNPDEFP | LAMTAYDGQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NIFSAVELPT | GSYKVEYPKT | EEMRGRSYTF | TIKQVNVLKL | GDLKEYMTGR | SSFNPRDVLQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GMDVVMKEHP | SKCMITVGKS | FFTRETEPDE | DFRFGVIAAK | GYRHTLKPTA | QGLSLCLDYS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLAFRKAMSV | IEYLKLYFNW | SDMRQFRRRD | VEEELIGLKV | TVNHRKNKQK | LTIVGLSMQN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TKDIKFDLID | QEGNEPPRKT | SIVEYFRIKY | GRHIVHKDIP | CLDLGKNGRQ | NFVPMEFCDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VEGQIYPKDN | LDKDSALWLK | KLSLVNPQQR | QRNIDKMIKA | RNGPSGGEII | GNFGLKVDTN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MTPVEGRVLK | APSLKLAERG | RVVREEPNPR | QNNQWNLMKK | GVTRGSIVKH | WAVLDFTASE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RFNKMPNDFV | DNLIDRCWRL | GMQMEAPIVY | KTSRMETLSN | GNAIEELLRS | VIDEASRKHG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GARPTLVLCA | MSRKDDGYKT | LKWIAETKLG | LVTQCFLTGP | ATKGGDQYRA | NLALKMNAKV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GGSNVELMDT | FSFFKKEDEV | MFIGADVNHP | AARDKMSPSI | VAVVGTLNWP | EANRYAARVI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AQPHRKEEIQ | GFGDACLELV | KAHVQATGKR | PNKIVIFRDG | VSDAQFDMVL | NVELLDVKLT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FEKNGYNPKI | TVIVAQKRHQ | TRFFPATNND | GSDKGNVPSG | TVVDTKVIHP | YEYDFYLCSH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HGGIGTSKPT | HYYTLWDELG | FTSDQVQKLI | FEMCFTFTRC | TKPVSLVPPV | YYADMVAFRG |
| 970 | 980 | 990 | 1000 | 1010 | |
| RMYHEASSRE | KNFKQPRGAS | TSAASLASSL | SSLTIEDKAI | FKLHAELENV | MFFV |