Q21691

PR
Gene name
nrde-3 (R04A9.2)
Protein name
Nuclear RNAi defective-3 protein
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_R04A9.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

322-392 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q21691

Entry ID Method Resolution Chain Position Source
AF-Q21691-F1 Predicted AlphaFoldDB

No variants for Q21691

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q21691

No associated diseases with Q21691

1 regional properties for Q21691

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 44 - 324 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • siRNA binding is necessary and sufficient for distribution of nrde-3 to the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNAi effector complex Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins.

5 GO annotations of molecular function

Name Definition
endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
miRNA binding Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
RNA binding Binding to an RNA molecule or a portion thereof.
single-stranded RNA binding Binding to single-stranded RNA.
siRNA binding Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.

4 GO annotations of biological process

Name Definition
olfactory learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
post-transcriptional gene silencing by RNA A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.
regulation of post-transcriptional gene silencing by RNA Any process that modulates the frequency, rate or extent of post-transcriptional gene silencing by RNA.
RNA import into nucleus The import of RNA from the cytoplasm to the nucleus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9SHF3 AGO2 Protein argonaute 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDLLDKVMGE MGSKPGSTAK KPATSASSTP RTNVWGTAKK PSSQQQPPKP LFTTPGSQQG
70 80 90 100 110 120
SLGGRIPKRE HTDRTGPDPK RKPLGGLSVP DSFNNFGTFR VQMNAWNLDI SKMDERISRI
130 140 150 160 170 180
MFRATLVHTD GRRFELSLGV SAFSGDVNRQ QRRQAQCLLF RAWFKRNPEL FKGMTDPAIA
190 200 210 220 230 240
AYDAAETIYV GCSFFDVELT EHVCHLTEAD FSPQEWKIVS LISRRSGSTF EIRIKTNPPI
250 260 270 280 290 300
YTRGPNALTL ENRSELTRII EAITDQCLHN EKFLLYSSGT FPTKGGDIAS PDEVTLIKSG
310 320 330 340 350 360
FVKTTKIVDR DGVPDAIMTV DTTKSPFYKD TSLLKFFTAK MDQLTNSGGG PRGHNGGRER
370 380 390 400 410 420
RDGGGNSRKY DDRRSPRDGE IDYDERTVSH YQRQFQDERI SDGMLNTLKQ SLKGLDCQPI
430 440 450 460 470 480
HLKDSKANRS IMIDEIHTGT ADSVTFEQKL PDGEMKLTSI TEYYLQRYNY RLKFPHLPLV
490 500 510 520 530 540
TSKRAKCYDF YPMELMSILP GQRIKQSHMT VDIQSYMTGK MSSLPDQHIK QSKLVLTEYL
550 560 570 580 590 600
KLGDQPANRQ MDAFRVSLKS IQPIVTNAHW LSPPDMKFAN NQLYSLNPTR GVRFQTNGKF
610 620 630 640 650 660
VMPARVKSVT IINYDKEFNR NVDMFAEGLA KHCSEQGMKF DSRPNSWKKV NLGSSDRRGT
670 680 690 700 710 720
KVEIEEAIRN GVTIVFGIIA EKRPDMHDIL KYFEEKLGQQ TIQISSETAD KFMRDHGGKQ
730 740 750 760 770 780
TIDNVIRKLN PKCGGTNFLI DVPESVGHRV VCNNSAEMRA KLYAKTQFIG FEMSHTGART
790 800 810 820 830 840
RFDIQKVMFD GDPTVVGVAY SLKHSAQLGG FSYFQESRLH KLTNLQEKMQ ICLNAYEQSS
850 860 870 880 890 900
SYLPETVVVY RVGSGEGDYP QIVNEVNEMK LAARKKKHGY NPKFLVICTQ RNSHIRVFPE
910 920 930 940 950 960
HINERGKSME QNVKSGTCVD VPGASHGYEE FILCCQTPLI GTVKPTKYTI IVNDCRWSKN
970 980 990 1000 1010 1020
EIMNVTYHLA FAHQVSYAPP AIPNVSYAAQ NLAKRGHNNY KTHTKLVDMN DYSYRIKEKH
1030 1040 1050
EEIISSEEVD DILMRDFIET VSNDLNAMTI NGRNFWA