Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

4 structures for O76922

Entry ID Method Resolution Chain Position Source
3NTH X-ray 280 A C 10-15 PDB
3NTI X-ray 280 A C 6-18 PDB
7CFD X-ray 270 A I/J/K/L/M/N/O/Z 6-18 PDB
AF-O76922-F1 Predicted AlphaFoldDB

No variants for O76922

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76922

No associated diseases with O76922

1 regional properties for O76922

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 71 - 364 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis
  • In the oocyte and later in the embryo, concentrates at the posterior pole as a component of polar granules
  • In the cytoplasm of syncytial embryos, accumulates in discrete foci
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.
precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.

3 GO annotations of molecular function

Name Definition
endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
piRNA binding Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
RNA binding Binding to an RNA molecule or a portion thereof.

25 GO annotations of biological process

Name Definition
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
dorsal appendage formation Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
global gene silencing by mRNA cleavage A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner.
heterochromatin assembly An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.
maintenance of pole plasm mRNA location The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
negative regulation of transposition Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
oocyte karyosome formation The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
P granule assembly The aggregation, arrangement and bonding together of a set of components to form a P granule.
piRNA biosynthetic process The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
pole cell development The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure.
pole cell formation Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
pole plasm protein localization Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.
positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
positive regulation of oskar mRNA translation Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.
positive regulation of post-transcriptional gene silencing by RNA Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA.
post-transcriptional gene silencing by RNA A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.
regulation of oskar mRNA translation Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.
regulation of pole plasm oskar mRNA localization Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.
segmentation The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9SHF3 AGO2 Protein argonaute 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNLPPNPVIA RGRGRGRKPN NVEANRGFAP SLGQKSDPSH SEGNQASGGN GGGGDAQVGP
70 80 90 100 110 120
SIEKSSLSAV QMHKSEGDPR GSVRGRRLIT DLVYSRPPGM TSKKGVVGTH ITVQANYFKV
130 140 150 160 170 180
LKRPNWTIYQ YRVDFTPDVE ATRLRRSFLY EHKGILGGYI FDGTNMFCIN QFKAVQDSPY
190 200 210 220 230 240
VLELVTKSRA GENIEIKIKA VGSVQSTDAE QFQVLNLILR RAMEGLDLKL VSRYYYDPQA
250 260 270 280 290 300
KINLENFRMQ LWPGYQTSIR QHENDILLCS EICHKVMRTE TLYNILSDAI RDSDDYQSTF
310 320 330 340 350 360
KRAVMGMVIL TDYNNKTYRI DDVDFQSTPL CKFKTNDGEI SYVDYYKKRY NIIIRDLKQP
370 380 390 400 410 420
LVMSRPTDKN IRGGNDQAIM IIPELARATG MTDAMRADFR TLRAMSEHTR LNPDRRIERL
430 440 450 460 470 480
RMFNKRLKSC KQSVETLKSW NIELDSALVE IPARVLPPEK ILFGNQKIFV CDARADWTNE
490 500 510 520 530 540
FRTCSMFKNV HINRWYVITP SRNLRETQEF VQMCIRTASS MKMNICNPIY EEIPDDRNGT
550 560 570 580 590 600
YSQAIDNAAA NDPQIVMVVM RSPNEEKYSC IKKRTCVDRP VPSQVVTLKV IAPRQQKPTG
610 620 630 640 650 660
LMSIATKVVI QMNAKLMGAP WQVVIPLHGL MTVGFDVCHS PKNKNKSYGA FVATMDQKES
670 680 690 700 710 720
FRYFSTVNEH IKGQELSEQM SVNMACALRS YQEQHRSLPE RILFFRDGVG DGQLYQVVNS
730 740 750 760 770 780
EVNTLKDRLD EIYKSAGKQE GCRMTFIIVS KRINSRYFTG HRNPVPGTVV DDVITLPERY
790 800 810 820 830 840
DFFLVSQAVR IGTVSPTSYN VISDNMGLNA DKLQMLSYKM THMYYNYSGT IRVPAVCHYA
850 860
HKLAFLVAES INRAPSAGLQ NQLYFL