Q9SAK8
PR
Gene name |
CHX2 (CHX02, At1g79400, T8K14.18) |
Protein name |
Cation/H(+) antiporter 2 |
Names |
Protein CATION/H+ EXCHANGER 2, AtCHX2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G79400 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SAK8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SAK8-F1 | Predicted | AlphaFoldDB |
55 variants for Q9SAK8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05173990 | 5 | L>S | No | 1000Genomes | |
| tmp_1_29865010_C_T | 7 | L>F | No | 1000Genomes | |
| ENSVATH05173992 | 38 | L>I | No | 1000Genomes | |
| ENSVATH01559553 | 41 | K>Q | No | 1000Genomes | |
| tmp_1_29865269_G_C | 59 | S>T | No | 1000Genomes | |
| ENSVATH05173994 | 85 | F>L | No | 1000Genomes | |
| ENSVATH05173996 | 111 | K>M | No | 1000Genomes | |
| ENSVATH05173997 | 114 | A>T | No | 1000Genomes | |
| ENSVATH05173998 | 146 | F>S | No | 1000Genomes | |
| ENSVATH13839602 | 148 | F>L | No | 1000Genomes | |
| ENSVATH14494135 | 150 | L>S | No | 1000Genomes | |
| ENSVATH14494136 | 169 | A>V | No | 1000Genomes | |
| tmp_1_29865683_A_G | 197 | Y>C | No | 1000Genomes | |
| ENSVATH14494137 | 200 | I>T | No | 1000Genomes | |
| ENSVATH14494138 | 218 | A>T | No | 1000Genomes | |
| ENSVATH05174000 | 223 | I>V | No | 1000Genomes | |
| tmp_1_29865853_T_G | 254 | F>V | No | 1000Genomes | |
| tmp_1_29865878_T_C | 262 | I>T | No | 1000Genomes | |
| ENSVATH13839604 | 288 | R>K | No | 1000Genomes | |
| tmp_1_29865968_A_G | 292 | Q>R | No | 1000Genomes | |
| tmp_1_29865996_T_A | 301 | F>L | No | 1000Genomes | |
| tmp_1_29865997_G_C | 302 | V>L | No | 1000Genomes | |
| ENSVATH05174005 | 369 | V>I | No | 1000Genomes | |
| ENSVATH13839606 | 403 | S>N | No | 1000Genomes | |
| ENSVATH01559557 | 416 | K>N | No | 1000Genomes | |
| tmp_1_29866603_C_A | 429 | N>K | No | 1000Genomes | |
| ENSVATH14494143 | 433 | E>K | No | 1000Genomes | |
| tmp_1_29866620_G_T | 435 | R>L | No | 1000Genomes | |
| tmp_1_29866662_C_T | 449 | A>V | No | 1000Genomes | |
| tmp_1_29866670_C_A | 452 | L>I | No | 1000Genomes | |
| ENSVATH05174007 | 464 | D>A | No | 1000Genomes | |
| tmp_1_29866739_C_A | 475 | P>T | No | 1000Genomes | |
| ENSVATH14494144 | 485 | M>L | No | 1000Genomes | |
| tmp_1_29866827_C_A | 504 | T>N | No | 1000Genomes | |
| tmp_1_29866897_A_T | 527 | Q>H | No | 1000Genomes | |
| tmp_1_29866924_T_A | 536 | N>K | No | 1000Genomes | |
| ENSVATH13839608 | 536 | N>Y | No | 1000Genomes | |
| ENSVATH01559558 | 555 | L>V | No | 1000Genomes | |
| tmp_1_29867054_A_G | 580 | N>D | No | 1000Genomes | |
| tmp_1_29867060_C_G | 582 | L>V | No | 1000Genomes | |
| tmp_1_29867066_C_G | 584 | H>D | No | 1000Genomes | |
| ENSVATH13839609 | 584 | H>Q | No | 1000Genomes | |
| tmp_1_29867073_C_T | 586 | P>L | No | 1000Genomes | |
| ENSVATH13839611 | 607 | D>N | No | 1000Genomes | |
| tmp_1_29867147_C_T | 611 | H>Y | No | 1000Genomes | |
| tmp_1_29867168_G_A | 618 | G>S | No | 1000Genomes | |
| ENSVATH05174010 | 620 | P>L | No | 1000Genomes | |
| tmp_1_29867190_C_G | 625 | A>G | No | 1000Genomes | |
| ENSVATH05174011 | 652 | A>V | No | 1000Genomes | |
| ENSVATH05174012 | 658 | N>I | No | 1000Genomes | |
| ENSVATH05174014 | 702 | I>M | No | 1000Genomes | |
| ENSVATH01559562 | 703 | E>D | No | 1000Genomes | |
| ENSVATH13839615 | 737 | M>T | No | 1000Genomes | |
| ENSVATH14494147 | 776 | S>* | No | 1000Genomes | |
| ENSVATH05174015 | 781 | I>L | No | 1000Genomes |
No associated diseases with Q9SAK8
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| solute:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8BH01 | Tmco3 | Transmembrane and coiled-coil domain-containing protein 3 | Mus musculus (Mouse) | PR |
| Q8VYR9 | KEA5 | K(+) efflux antiporter 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0CG16 | CHX6b | Cation/H(+) antiporter 6B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M007 | CHX27 | Cation/H(+) antiporter 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPKLLLCLP | QGDELFNPLN | TMFIQMACIL | VFSQLFYLLL | KPCGQAGPVA | QILAGIVLSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLLSRIPKVK | EFFLQKNAAD | YYSFFSFALR | TSFMFLIGLE | VDLHFMRRNF | KKAAVITLSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FVVSGLLSFA | SLMLFIPLFG | IKEDYFTFFL | VLLVTLSNTA | SPVVVRSIAD | WKLNTCEIGR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTISCALFIE | LTNVVLYTII | MAFISGTIIL | ELFLFLLATV | ALILINMVLA | PWLPKRNPKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KYLSKAETLV | FFIFLLIIGI | TIESYDVNSS | VSVFAIGIMF | PRQGKTHRTL | IQRLSYPIHE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVLPVYFGYI | GFRFSIIALT | KRFYLGIVII | VIVTIAGKFI | GVISACMYLK | IPKKYWLFLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TILSVKGHVG | LLLLDSNYSE | KKWWTTTIHD | MMVAALVITT | LVSGVLASFL | LKTREKDFAY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EKTSLESHNT | NEELRILSCA | YGVRHARGAI | SLVSALSGSR | GASDPFTPLL | MHLVPLPKKR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KSELMYHEHD | EDGGNANGDD | EFGTNEGLEI | NDSIDSFAKD | SKILIQQVKL | VTQMLNMHEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ICNATEDLRV | SIVFLPFHKH | QRIDGKTTND | GELFRQMNRN | VLRHGPCSIG | IFVDRNITGF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QQPHGFDSVQ | HVATLFFGGP | DDREALALCR | WLANNTLIHL | TVIQFVSEES | KAETPVGNAM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TRDNNEVFME | VLGRNQTEQE | TDRSFLEEFY | NRFVTTGQVG | FIEKLVSNGP | HTLTILREIG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EMYSLFVVGK | STGDCPMTVR | MKDWEECPEL | GTVGDFLASS | LDVNASVLVV | QRQRHSHDSF |
| IDD |