Q8VYR9

PR
Gene name
KEA5
Protein name
K(+) efflux antiporter 5
Names
AtKEA5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G51710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VYR9

Entry ID Method Resolution Chain Position Source
AF-Q8VYR9-F1 Predicted AlphaFoldDB

23 variants for Q8VYR9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07396888 5 A>T No 1000Genomes
ENSVATH14626479 5 A>V No 1000Genomes
ENSVATH12705717 66 P>H No 1000Genomes
tmp_5_21007981_C_T 108 R>K No 1000Genomes
tmp_5_21007426_C_G 194 G>A No 1000Genomes
ENSVATH12705671 225 M>L No 1000Genomes
ENSVATH07396865 234 V>I No 1000Genomes
tmp_5_21006779_C_A 238 G>V No 1000Genomes
ENSVATH12705668 252 V>L No 1000Genomes
ENSVATH12705667 267 V>I No 1000Genomes
ENSVATH00727460 291 S>F No 1000Genomes
ENSVATH07396862 297 T>A No 1000Genomes
tmp_5_21006282_C_T 313 A>T No 1000Genomes
tmp_5_21006276_G_T 315 L>I No 1000Genomes
tmp_5_21006257_T_C 321 N>S No 1000Genomes
tmp_5_21006063_G_T 355 R>S No 1000Genomes
ENSVATH03410458 436 I>V No 1000Genomes
tmp_5_21005275_T_C 473 N>S No 1000Genomes
tmp_5_21005143_C_A 485 A>S No 1000Genomes
ENSVATH07396850 544 P>H No 1000Genomes
ENSVATH12705631 548 S>C No 1000Genomes
tmp_5_21004753_G_A 549 S>F No 1000Genomes
tmp_5_21004750_G_A 550 P>L No 1000Genomes

No associated diseases with Q8VYR9

1 regional properties for Q8VYR9

Type Name Position InterPro Accession
domain Cation/H+ exchanger 274 - 662 IPR006153

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Multi-pass membrane protein
  • Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
  • Prevacuolar compartment membrane ; Multi-pass membrane protein
  • Endomembrane system ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8BH01 Tmco3 Transmembrane and coiled-coil domain-containing protein 3 Mus musculus (Mouse) PR
P0CG16 CHX6b Cation/H(+) antiporter 6B Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAK8 CHX2 Cation/H(+) antiporter 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M007 CHX27 Cation/H(+) antiporter 27 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MARFAVIGLT FLLLLGTSLS ARSDEETRER FYGNVVNSTA PGNGEGSIAK MFDRVLEKEF
70 80 90 100 110 120
SENDSPEGSD GASFNSSVAD QQAEIETVAK VTHEKGKRND TQENNGTRPF QLQDVFSLEN
130 140 150 160 170 180
EDSDDMTLID KKNNVFVMSN KKSKYPILQV DLRLISDLVV IIVFAAIGGI VFSCLGQPVI
190 200 210 220 230 240
VGYLLAGSII GPGGLKFISE MVQVETVAQF GVVFLLFALG LEFSMTKLKV VGPVAVLGGL
250 260 270 280 290 300
LQIVLLMFLC GVTALLCGAR LSEGIFVGAF LSMSSTAVVV KFLVERNSTS SLHGQVTIGI
310 320 330 340 350 360
LIFQDCVVGL LFALLPVLGG NSGLLQGIIS MGKLLLILSI YLTVASLLTW SFVPRFLKLM
370 380 390 400 410 420
IQLSSQTNEL YQLAAVAFCL LSAWCSDKLG LSLELGSFVA GVMLSTTEFA QHTLEQVEPI
430 440 450 460 470 480
RNLFAALFLS SIGMLINVHF LWNHVDILLA SVILVIVIKT AIAAVVVKAF RYNMRISFHV
490 500 510 520 530 540
GVLLAQIGEF AFVLLSRASN LHVIEGKMYL LLLGTTALSL VTTPLLFKLI PSAMNLGVLL
550 560
RWFPSENSSP NESLQEKASL IEVHNRTK