Q8BH01

PR
Gene name
Tmco3
Protein name
Transmembrane and coiled-coil domain-containing protein 3
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:234076
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

135-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BH01

Entry ID Method Resolution Chain Position Source
AF-Q8BH01-F1 Predicted AlphaFoldDB

28 variants for Q8BH01

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3398566642 44 T>S No EVA
rs214376258 80 K>R No EVA
rs231232742 82 T>A No EVA
rs3388968574 169 N>K No EVA
rs3388974962 172 H>Q No EVA
rs3388968586 183 I>N No EVA
rs3388967262 215 E>V No EVA
rs3388975022 302 C>S No EVA
rs3388975012 333 F>L No EVA
rs3388948587 424 M>I No EVA
rs240530848 445 G>S No EVA
rs3398458491 540 M>R No EVA
rs3398944729 541 V>I No EVA
rs3398458382 542 T>S No EVA
rs3398738217 543 E>* No EVA
rs3398738227 543 E>A No EVA
rs3398288110 544 E>V No EVA
rs3398567663 545 I>T No EVA
rs6286457 547 T>A No EVA
rs3398788972 548 Y>C No EVA
rs3413124480 550 E>K No EVA
rs3388948635 554 D>V No EVA
rs3388974395 555 F>I No EVA
rs3388974377 562 A>E No EVA
rs3388972268 565 G>W No EVA
rs3388959317 576 E>K No EVA
rs3388968692 631 R>* No EVA
rs3388923653 655 L>I No EVA

No associated diseases with Q8BH01

1 regional properties for Q8BH01

Type Name Position InterPro Accession
domain Cation/H+ exchanger 274 - 662 IPR006153

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P0CG16 CHX6b Cation/H(+) antiporter 6B Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAK8 CHX2 Cation/H(+) antiporter 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M007 CHX27 Cation/H(+) antiporter 27 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYR9 KEA5 K(+) efflux antiporter 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKVLDQSLLW MLLPFFHLIA SAAEHEEVAK HAIKLHRGKG ATATQRKQWA LDSCRRLTGL
70 80 90 100 110 120
LRQKNVVLNK LKNAIRAVEK DTSLSGEEKL FQVHTFEIFQ KELNESENSI FQAIYGLQRA
130 140 150 160 170 180
LQGDYRDVVN MKESSKQRLE ALREAAIKEE TEYVELLAAE KHQVEALKNM QHQNKSLSML
190 200 210 220 230 240
DEILEDVRKA ADRLEEEIEE HAFDDNKSVK GVNFEAVLRV EEEEASSKQN MTKREVEDGL
250 260 270 280 290 300
GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI
310 320 330 340 350 360
ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWRI SLQGPCYMTL
370 380 390 400 410 420
LMIAFGLWWG HLLRIRPTQS VFISTCLSLS STPLVSRFLV GSARGDKEAG DIDYSTVLLG
430 440 450 460 470 480
MLVMQDVQLG LFIAVMPTLI QAGAGASSSV VMEVLRILFL IGQILFSLAA VFLLCLVMKT
490 500 510 520 530 540
YLIGPYYRKL HLESKGNKEI LVLGVSAFTF LMLTVTELLD VSMELGCFLA GALVSSQGHM
550 560 570 580 590 600
VTEEIMTYIE PIRDFLAIIF FASIGLHVFP TFVIYELTVL VFLTLSVVIM KFVLAVLVLS
610 620 630 640 650 660
LILPRSSQYI KWIVSAGLAQ VSEFSFVLGS RARRAGILSR EVYLLILSVT TLSLLLAPVL
670
WKAAITKCVP RPERRSSL