Q9QYK4
Gene name |
Hs6st3 |
Protein name |
Heparan-sulfate 6-O-sulfotransferase 3 |
Names |
HS6ST-3, mHS6ST-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:50787 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QYK4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QYK4-F1 | Predicted | AlphaFoldDB |
19 variants for Q9QYK4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389350033 | 50 | A>T | No | EVA | |
| rs52665750 | 78 | P>R | No | EVA | |
| rs3389300949 | 145 | D>H | No | EVA | |
| rs3412896505 | 163 | H>Y | No | EVA | |
| rs3405876441 | 207 | L>P | No | EVA | |
| rs3389329641 | 229 | R>H | No | EVA | |
| rs3389347633 | 252 | S>N | No | EVA | |
| rs3389337930 | 268 | H>R | No | EVA | |
| rs52011479 | 271 | D>E | No | EVA | |
| rs3389359585 | 278 | D>V | No | EVA | |
| rs3389342848 | 297 | F>L | No | EVA | |
| rs3389350165 | 346 | N>I | No | EVA | |
| rs3389350167 | 377 | Q>E | No | EVA | |
| rs3389311616 | 390 | D>V | No | EVA | |
| rs3389318009 | 393 | R>C | No | EVA | |
| rs3389311627 | 397 | E>D | No | EVA | |
| rs3389337961 | 421 | T>N | No | EVA | |
| rs3389363522 | 426 | H>Y | No | EVA | |
| rs3389350221 | 445 | A>T | No | EVA |
No associated diseases with Q9QYK4
No regional properties for Q9QYK4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9QYK4 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| heparan sulfate 6-O-sulfotransferase activity | Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| heparan sulfate proteoglycan biosynthetic process | The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. |
| heparan sulfate proteoglycan biosynthetic process, enzymatic modification | The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDERFNKWLL | TPVLTLLFVV | IMYQYVSPSC | TSSCTNFGEQ | LRSGEARPPA | VPSPARRAQA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLDEWERRPQ | LPPPPRGPPE | GSRGVAAPED | EDEDPGDPEE | EEEEEEEEPD | PEAPENGSLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RFVPRFNFTL | KDLTRFVDFN | IKGRDVIVFL | HIQKTGGTTF | GRHLVKNIRL | EQPCSCKAGQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKCTCHRPGK | KETWLFSRFS | TGWSCGLHAD | WTELTNCVPA | IMEKKDCPRN | HSHTRNFYYI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TMLRDPVSRY | LSEWKHVQRG | ATWKTSLHMC | DGRSPTPDEL | PTCYPGDDWS | GVSLREFMDC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SYNLANNRQV | RMLADLSLVG | CYNLTFMNES | ERNTILLQSA | KNNLKNMAFF | GLTEFQRKTQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLFERTFNLK | FISPFTQFNI | TRASNVDIND | GARQHIEELN | FLDMQLYEYA | KDLFQQRYHH |
| 430 | 440 | 450 | 460 | ||
| TKQLEHQRDR | QKRREERRLQ | REHRAHRWPK | EDRAMEGTVT | EDYNSQVVRW |