AiPD: Autoinhibited Protein Database

Q8IZP7

Gene name	HS6ST3
Protein name	Heparan-sulfate 6-O-sulfotransferase 3
Names	HS6ST-3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:266722
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-148 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

5-148 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8IZP7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8IZP7-F1	Predicted				AlphaFoldDB

397 variants for Q8IZP7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1463670962 CA388678652	3	E>D		No	ClinGen gnomAD
rs767415756 CA7023341	4	R>K		No	ClinGen ExAC gnomAD
CA7023340 rs767415756	4	R>M		No	ClinGen ExAC gnomAD
CA388678665 rs1594672267	5	F>L		No	ClinGen Ensembl
rs755841123 CA7023342	6	N>D		No	ClinGen ExAC TOPMed gnomAD
CA7023343 rs766044241	9	L>P		No	ClinGen ExAC gnomAD
CA7023344 rs753305976	13	V>G		No	ClinGen ExAC gnomAD
CA388678717 rs1200124912	14	L>V		No	ClinGen TOPMed
rs1318099792 CA388678726	15	T>I		No	ClinGen TOPMed
rs1420209243 CA388678729	16	L>V		No	ClinGen TOPMed gnomAD
rs200021006 CA7023345	17	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA388678745 rs1337031941	18	F>L		No	ClinGen gnomAD
CA7023347 rs142119153	21	I>L		No	ClinGen ESP ExAC gnomAD
CA388678771 rs1395852477	22	M>I		No	ClinGen TOPMed
CA388678775 COSM1677752 rs1450259717	23	Y>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs757556487 CA7023348	25	Y>C		No	ClinGen ExAC gnomAD
CA388678801 rs1306326985	26	V>A		No	ClinGen gnomAD
rs1223167840 CA388678799	26	V>M		No	ClinGen gnomAD
CA7023350 rs746053200	27	S>F		No	ClinGen ExAC gnomAD
CA388678806 rs746053200	27	S>Y		No	ClinGen ExAC gnomAD
CA7023352 rs780450829	28	P>L		No	ClinGen ExAC
CA7023351 rs368968234	28	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA388678827 rs1466351843	31	T>A		No	ClinGen TOPMed
CA388678829 rs749310541	31	T>N		No	ClinGen ExAC gnomAD
CA7023354 rs749310541	31	T>S		No	ClinGen ExAC gnomAD
CA7023355 rs768919486	32	S>G		No	ClinGen ExAC TOPMed gnomAD
CA255152955 rs200686308	34	C>Y		No	ClinGen Ensembl
rs969304179 CA255152956	36	N>S		No	ClinGen TOPMed gnomAD
CA7023356 rs774156626	37	F>L		No	ClinGen ExAC gnomAD
rs761853786 CA7023357	38	G>R		No	ClinGen ExAC gnomAD
CA7023359 rs773012377	41	P>S		No	ClinGen ExAC gnomAD
CA388678899 rs1390905665	42	R>C		No	ClinGen gnomAD
TCGA novel	42	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1412407517 CA388678905	43	A>S		No	ClinGen gnomAD
rs375039520 CA7023361	44	G>A		No	ClinGen ExAC TOPMed gnomAD
rs375039520 CA7023362	44	G>V		No	ClinGen ExAC TOPMed gnomAD
CA7023363 rs146203986	45	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs764795172 CA7023364	46	A>V		No	ClinGen ExAC gnomAD
rs199618938 CA7023365	48	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs952506115 CA255152957	48	P>Q		No	ClinGen TOPMed gnomAD
CA7023369 rs750758063	50	A>G		No	ClinGen ExAC TOPMed gnomAD
rs781568425 CA7023367	50	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7023368 rs750758063	50	A>V		No	ClinGen ExAC TOPMed gnomAD
rs780413956 CA7023370	51	V>I		No	ClinGen ExAC TOPMed gnomAD
CA7023373 rs779101559	52	P>L		No	ClinGen ExAC gnomAD
rs768829684 CA7023372	52	P>S		No	ClinGen ExAC TOPMed gnomAD
CA388678957 rs1476812587	53	G>A		No	ClinGen TOPMed gnomAD
rs1476812587 CA388678958	53	G>V		No	ClinGen TOPMed gnomAD
rs1162677281 CA388678960	54	P>A		No	ClinGen TOPMed
TCGA novel	54	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388678961 rs1162677281	54	P>T		No	ClinGen TOPMed
CA7023375 rs772006130	55	A>S		No	ClinGen ExAC gnomAD
rs1366603219 CA388678972	56	R>C		No	ClinGen TOPMed
CA388678973 rs1409215736	56	R>L		No	ClinGen TOPMed gnomAD
CA388678979 rs1440052509	57	R>P		No	ClinGen TOPMed
rs1594672438 CA388678977	57	R>W		No	ClinGen Ensembl
CA7023376 rs773030031	58	A>G		No	ClinGen ExAC gnomAD
rs760406251 CA7023377	60	A>E		No	ClinGen ExAC gnomAD
rs1237235400 CA388679002	61	P>L		No	ClinGen TOPMed
CA7023378 rs770770230	62	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1267458299 CA388679013	63	E>A		No	ClinGen TOPMed
rs776259604 CA7023379	64	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1594672459 CA388679027	65	W>G		No	ClinGen Ensembl
TCGA novel	66	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388679034 rs1354906269	66	E>K		No	ClinGen TOPMed
rs921525067 CA255152958	67	R>Q		No	ClinGen TOPMed
CA388679046 rs1566879487	68	R>W		No	ClinGen Ensembl
rs1353429550 CA388679061	70	Q>R		No	ClinGen TOPMed
CA388679074 rs1330631202	72	P>S		No	ClinGen TOPMed gnomAD
rs1219432944 CA388679082	73	P>L		No	ClinGen TOPMed gnomAD
CA255152959 rs932883553	73	P>S		No	ClinGen TOPMed gnomAD
CA388679087 rs1434543953	74	P>R		No	ClinGen TOPMed gnomAD
CA255152960 rs1043618847	75	P>S		No	ClinGen TOPMed gnomAD
rs1420151029 CA388679095	76	R>W		No	ClinGen TOPMed
rs934765732 CA255152961	77	G>E		No	ClinGen TOPMed
rs1211171924 CA388679101	77	G>R		No	ClinGen TOPMed gnomAD
rs1217969300 CA388679107	78	P>H		No	ClinGen TOPMed
rs764629460 CA7023382	78	P>S		No	ClinGen ExAC TOPMed gnomAD
rs764629460 CA388679105	78	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1284327720 CA388679115	79	P>L		No	ClinGen TOPMed
TCGA novel	79	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1202503369 CA388679116	80	E>K		No	ClinGen TOPMed
rs1223921065 CA388679127	81	G>E		No	ClinGen gnomAD
rs1362150104 CA388679124	81	G>R		No	ClinGen TOPMed gnomAD
CA388679132 rs1449421544	82	P>R		No	ClinGen gnomAD
rs547017074 CA7023384	82	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388679137 rs1478518650	83	R>Q		No	ClinGen TOPMed gnomAD
rs1474879980 CA388679150	85	A>G		No	ClinGen TOPMed gnomAD
CA388679146 rs1242407333	85	A>T		No	ClinGen TOPMed gnomAD
rs1474879980 CA388679151	85	A>V		No	ClinGen TOPMed gnomAD
CA388679161 rs1186375363	87	A>E		No	ClinGen TOPMed gnomAD
rs1186375363 CA388679163	87	A>V		No	ClinGen TOPMed gnomAD
CA388679168 rs1566879554	88	P>R		No	ClinGen Ensembl
rs1594672536 CA388679164	88	P>T		No	ClinGen Ensembl
CA7023386 rs762396340	90	E>K		No	ClinGen ExAC gnomAD
rs1390080419 CA388679190	91	E>V		No	ClinGen gnomAD
CA255152965 rs1027268963	93	E>Q		No	ClinGen TOPMed
rs1425161456 CA388679216	95	P>S		No	ClinGen TOPMed
CA255152966 rs952537245	96	G>E		No	ClinGen TOPMed gnomAD
TCGA novel	96	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388679233 rs767998739	97	D>E		No	ClinGen ExAC TOPMed gnomAD
CA388679228 rs1320533006	97	D>H		No	ClinGen gnomAD
CA7023388 rs750904009	98	P>L		No	ClinGen ExAC gnomAD
rs750904009 CA388679239	98	P>R		No	ClinGen ExAC gnomAD
rs756546564 CA7023389	99	R>G		No	ClinGen ExAC gnomAD
rs780608215 CA7023390	99	R>Q		No	ClinGen ExAC TOPMed
CA388679250 rs1247316859	100	E>D		No	ClinGen gnomAD
CA388679244 rs1385485454	100	E>Q		No	ClinGen gnomAD
rs1594672592 CA388679284	105	E>A		No	ClinGen Ensembl
TCGA novel	105	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1446015396 CA388679298	107	E>Q		No	ClinGen gnomAD
CA388679312 rs570109434 CA388679311	108	D>E		No	ClinGen 1000Genomes TOPMed
rs1206472409 CA388679326	110	P>L		No	ClinGen gnomAD
TCGA novel	111	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1244714799 CA388679327	111	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1003943845 CA255152969	112	P>S		No	ClinGen TOPMed gnomAD
rs1268310394 COSM1368111 CA388679342	113	E>K	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	113	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748194459 CA7023394	114	A>T		No	ClinGen ExAC gnomAD
CA388679352 rs1471123689	114	A>V		No	ClinGen TOPMed gnomAD
CA255152971 rs1014953527	115	P>A		No	ClinGen Ensembl
rs758423490 CA7023395	115	P>R		No	ClinGen ExAC gnomAD
CA388679377 rs1318837136	118	G>D		No	ClinGen gnomAD
CA388679373 rs747013290	118	G>R		No	ClinGen ExAC gnomAD
CA7023397 COSM1368112 rs747013290	118	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs539388986 CA7023400	119	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7023399 rs776458825	119	S>P		No	ClinGen ExAC TOPMed gnomAD
CA388679385 rs1278564509	120	L>P		No	ClinGen gnomAD
CA7023401 rs769443893	121	P>S		No	ClinGen ExAC gnomAD
COSM3688797 CA7023402 rs775008092	122	R>G	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA388679394 rs1445017268	122	R>P		No	ClinGen gnomAD
CA388679393 rs1445017268	122	R>Q		No	ClinGen gnomAD
CA388679403 rs1174701731	123	F>L		No	ClinGen Ensembl
CA388679398 rs1464628152	123	F>V		No	ClinGen TOPMed
rs763581675 CA7023404	125	P>Q		No	ClinGen ExAC gnomAD
CA7023403 rs762464615	125	P>S		No	ClinGen ExAC gnomAD
rs1226165605 CA388679417	126	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388679429 rs1418041661	128	N>D		No	ClinGen TOPMed
TCGA novel	130	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7023407 rs202155118	132	K>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	133	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7023408 rs754216164	134	L>R		No	ClinGen ExAC TOPMed gnomAD
CA7023409 rs755302154	135	T>S		No	ClinGen ExAC TOPMed gnomAD
CA388679484 rs1472337372	136	R>H		No	ClinGen gnomAD
rs1472337372 CA388679486	136	R>L		No	ClinGen gnomAD
CA7023410 rs765443028	137	F>C		No	ClinGen ExAC gnomAD
rs1185788411 CA388679493	137	F>L		No	ClinGen TOPMed
rs185615621 CA7023411	138	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs926138268 CA255152973	139	D>G		No	ClinGen TOPMed gnomAD
CA388679508 rs1316136922	140	F>V		No	ClinGen TOPMed
rs1330205327 CA388679519	141	N>K		No	ClinGen gnomAD
rs150396139 CA7023413	141	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA388679517 rs150396139	141	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA388679531 rs1473659149	143	K>R		No	ClinGen gnomAD
rs139534660 CA255152974 COSM107781	145	R>C	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA388679544 rs1284652600	145	R>H		No	ClinGen gnomAD
CA7023421 rs577304138	157	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs753365436	158	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA388679633 rs1196287234	158	G>D		No	ClinGen gnomAD
TCGA novel	158	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1445485820 CA388679682	166	V>L		No	ClinGen TOPMed
rs1392313548 CA388679703	169	I>V		No	ClinGen gnomAD
CA7023424 rs761444493	170	R>W		No	ClinGen ExAC gnomAD
rs766926849 CA7023425	172	E>G		No	ClinGen ExAC gnomAD
TCGA novel	177	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1376261301 CA388679767	178	K>R		No	ClinGen TOPMed gnomAD
rs752931338 CA388679774	179	A>E		No	ClinGen ExAC gnomAD
CA7023428 rs142109918	179	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs752931338 CA7023429	179	A>V		No	ClinGen ExAC gnomAD
CA388679778 rs758596974	180	G>D		No	ClinGen ExAC gnomAD
CA7023430 rs758596974	180	G>V		No	ClinGen ExAC gnomAD
rs1054334972 CA255152977	181	Q>E		No	ClinGen TOPMed gnomAD
rs965100269 CA255152978	182	K>T		No	ClinGen TOPMed
CA7023431 rs546169910	185	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA388679813 rs546169910	185	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs370156586 CA7023432	187	H>R		No	ClinGen ESP ExAC gnomAD
CA388679830 rs781047206	188	R>G		No	ClinGen ExAC gnomAD
TCGA novel	188	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7023434 rs781047206	188	R>W		No	ClinGen ExAC gnomAD
TCGA novel	190	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1411212330 CA388679844	190	G>V		No	ClinGen gnomAD
CA388679846 rs1227802489	191	K>Q		No	ClinGen gnomAD
rs755909244 CA7023437	194	T>A		No	ClinGen ExAC gnomAD
CA388679879 rs1222344701	195	W>S		No	ClinGen TOPMed
TCGA novel	197	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388679921 rs1289431364	201	S>F		No	ClinGen gnomAD
CA388679925 rs1452131799	202	T>A		No	ClinGen TOPMed
CA388679924 rs1452131799	202	T>P		No	ClinGen TOPMed
rs900676719 CA255152979	203	G>S		No	ClinGen Ensembl
rs779764665 CA7023438	205	S>G		No	ClinGen ExAC gnomAD
CA7023439 rs199763203	205	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs768156865 CA388679948	205	S>R		No	ClinGen ExAC TOPMed gnomAD
CA388679960 rs1430526917	207	G>W		No	ClinGen gnomAD
TCGA novel	210	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA255152980 rs932185827	211	D>H		No	ClinGen TOPMed gnomAD
CA388679983 rs932185827	211	D>N		No	ClinGen TOPMed gnomAD
rs1448166117 CA388680030	217	N>I		No	ClinGen TOPMed gnomAD
CA388680029 rs1448166117	217	N>S		No	ClinGen TOPMed gnomAD
CA7023443 rs747605056	218	C>Y		No	ClinGen ExAC gnomAD
CA388680041 rs1457026412	219	V>L		No	ClinGen gnomAD
CA388680051 rs1291290522	220	P>L		No	ClinGen gnomAD
rs771767570 CA388680064	222	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7023445 rs777275367	223	M>R		No	ClinGen ExAC gnomAD
rs1566879802 CA388680074	224	E>K		No	ClinGen Ensembl
CA388680101 rs1319596279	227	D>G		No	ClinGen gnomAD
rs759999343 CA7023447	228	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA388680112 rs1248050793	229	P>T		No	ClinGen gnomAD
rs770170732 CA7023448	230	R>C		No	ClinGen ExAC gnomAD
rs1301808006 CA388680120	230	R>H		No	ClinGen TOPMed
CA7023449 rs145937254	232	H>P		No	ClinGen ExAC gnomAD
CA255152981 rs956242483	233	S>R		No	ClinGen TOPMed
rs563195462 CA7023450	234	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1486945799 CA388680157	235	T>I		No	ClinGen gnomAD
rs1209634121 CA388680158	236	R>G		No	ClinGen gnomAD
CA255501992 COSM949052 rs897776283	238	F>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs760818583 CA7023477	238	F>V		No	ClinGen ExAC TOPMed gnomAD
rs1225612964 CA388682472	239	Y>C		No	ClinGen gnomAD
CA255501993 rs927498549	241	I>L		No	ClinGen TOPMed gnomAD
CA7023479 rs547660939	243	M>I		No	ClinGen 1000Genomes ExAC
CA388682499 rs952199755	243	M>K		No	ClinGen TOPMed
CA255501994 rs952199755	243	M>T		No	ClinGen TOPMed
rs1312028803 CA388682497	243	M>V		No	ClinGen gnomAD
CA7023481 rs774015751	248	V>A		No	ClinGen ExAC TOPMed gnomAD
CA7023480 rs373578498	248	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA255501995 rs577710385	250	R>C		No	ClinGen Ensembl
CA255501996 rs761740630	250	R>H		No	ClinGen Ensembl
CA388682565 rs1484788053	254	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs984579124 CA255501997	259	Q>R		No	ClinGen TOPMed
rs761937904 CA255501998	263	T>I		No	ClinGen Ensembl
rs1467066285 CA388682634	264	W>R		No	ClinGen TOPMed
COSM1607283 rs1431291170 CA388682638	264	W>S	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
VAR_028159 rs9516771 CA7023489	265	K>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7023491 rs533169440	267	S>C		No	ClinGen 1000Genomes ExAC gnomAD
rs748546537 CA7023492	268	L>F		No	ClinGen ExAC TOPMed gnomAD
rs748546537 CA388682662	268	L>I		No	ClinGen ExAC TOPMed gnomAD
rs772219507 CA388682670	269	H>P		No	ClinGen ExAC gnomAD
rs772219507 CA7023493	269	H>R		No	ClinGen ExAC gnomAD
rs370498700 CA7023494	270	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA388682675 rs1406969243	270	M>V		No	ClinGen TOPMed gnomAD
TCGA novel	273	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs878918117 CA255501999	273	G>R		No	ClinGen Ensembl
CA7023496 rs766548912	274	R>S		No	ClinGen ExAC TOPMed
CA388682713 rs1367340948	275	S>I		No	ClinGen gnomAD
CA388682716 rs1217766729	275	S>R		No	ClinGen gnomAD
rs1343439499 CA388682730	278	P>A		No	ClinGen gnomAD
rs1205117891 CA388682734	278	P>L		No	ClinGen gnomAD
CA7023499 rs765286528	279	D>G		No	ClinGen ExAC
CA7023498 rs759593534	279	D>H		No	ClinGen ExAC gnomAD
TCGA novel	279	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1180606417 CA388682741	280	E>K		No	ClinGen TOPMed
rs111276045 CA255502000	281	L>M		No	ClinGen Ensembl
CA7023502 rs763591899	282	P>L		No	ClinGen ExAC gnomAD
CA388682753 rs1221834783	282	P>T		No	ClinGen gnomAD
rs558493144 CA7023503	283	T>I		No	ClinGen ExAC gnomAD
CA388682782 rs1210783544	286	P>R		No	ClinGen TOPMed
rs149905583 CA7023504	286	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs971130663 CA255502002	288	D>N		No	ClinGen TOPMed
CA388682804 rs1387836837	289	D>E		No	ClinGen gnomAD
rs1448759577 CA388682812	290	W>C		No	ClinGen gnomAD
rs1166694394 CA388682817	291	S>Y		No	ClinGen gnomAD
CA388682850 rs191316541	296	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7023508 rs191316541	296	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7023506 rs150881911	296	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7023509 rs142184149	299	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA7023510 rs772545385	300	D>G		No	ClinGen ExAC gnomAD
rs868456363 CA255502004	302	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	307	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1366428830 CA388682926	307	N>S		No	ClinGen TOPMed gnomAD
rs1054566348 CA255502006	308	N>S		No	ClinGen TOPMed gnomAD
CA255502007 rs144389562	309	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
rs763499432 CA7023511	309	R>H		No	ClinGen ExAC TOPMed gnomAD
rs763499432 CA388682940	309	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1228332409 COSM697170 CA388682947	310	Q>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA388682941 rs1360973604	310	Q>K		No	ClinGen gnomAD
rs747297518 CA7023512	312	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA388682957 COSM311860 rs770895513	312	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7023513 rs770895513	312	R>L		No	ClinGen ExAC TOPMed gnomAD
CA388682978 rs1566464558	315	A>V		No	ClinGen Ensembl
TCGA novel	317	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388683000 rs1464319337	318	S>R		No	ClinGen gnomAD
rs1244825117 CA388683047	325	L>F		No	ClinGen TOPMed gnomAD
rs1413207592 CA388683067	328	M>R		No	ClinGen gnomAD
CA7023516 rs765198671	328	M>V		No	ClinGen ExAC gnomAD
COSM3943291 CA7023520 rs751137557	330	E>G	ovary [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA7023518 rs762824439	330	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7023519 rs762824439	330	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	331	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1434918736 CA388683114	334	N>K		No	ClinGen TOPMed gnomAD
rs1200274366 CA388683111	334	N>S		No	ClinGen TOPMed
rs866128801 CA255502009	339	Q>R		No	ClinGen Ensembl
CA388683162 rs1265637589	342	K>E		No	ClinGen TOPMed
TCGA novel	342	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388683170 rs1449435488	343	N>D		No	ClinGen TOPMed gnomAD
rs1566464592 CA388683173	343	N>S		No	ClinGen Ensembl
CA388683185 rs1283127419	345	L>M		No	ClinGen gnomAD
rs761573907 CA7023521	346	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7023522 rs767109653	348	M>V		No	ClinGen ExAC gnomAD
CA388683222 rs1268298882	350	F>C		No	ClinGen gnomAD
TCGA novel	350	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA388683248 rs1435941989	354	T>A		No	ClinGen TOPMed gnomAD
CA388683249 rs1435941989	354	T>S		No	ClinGen TOPMed gnomAD
CA388683297 rs1347977104	360	T>I		No	ClinGen TOPMed
CA388683329 rs1278881977	365	E>Q		No	ClinGen TOPMed
rs753269473 CA7023526	366	R>G		No	ClinGen ExAC
rs1186699244 CA388683346	367	T>I		No	ClinGen TOPMed gnomAD
CA388683370 rs1471816229	371	K>Q		No	ClinGen gnomAD
CA7023530 rs141432230	374	S>C		No	ClinGen ESP ExAC gnomAD
rs141432230 CA255502011	374	S>F		No	ClinGen ESP ExAC gnomAD
COSM551995 CA7023531 rs368326730	375	P>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1300322142 CA388683434	380	N>D		No	ClinGen TOPMed
CA7023533 rs770052568	380	N>S		No	ClinGen ExAC gnomAD
rs1310677752 CA388683441	381	I>N		No	ClinGen gnomAD
CA7023534 rs775560930	381	I>V		No	ClinGen ExAC gnomAD
rs1417931169 CA388683450	382	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs761521237 CA7023538	383	R>Q		No	ClinGen ExAC gnomAD
rs774158340 CA7023537	383	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750137502 CA7023540	387	V>M		No	ClinGen ExAC TOPMed gnomAD
CA388683488 rs1276427992	389	I>V		No	ClinGen gnomAD
rs751925902 CA7023542 COSM3711415	391	E>K	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	392	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753181449 CA7023543	392	G>V		No	ClinGen ExAC gnomAD
CA7023545 rs778172720	394	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7023546 rs377277765	394	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs777469390 CA7023547 COSM432636	396	R>C	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs753503506 CA7023548	396	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7023549 rs746155531	397	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1012757715 CA255502014	398	E>G		No	ClinGen TOPMed
rs376423293 CA7023550	398	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7023551 rs780327968	399	D>N		No	ClinGen ExAC TOPMed gnomAD
CA388683549 rs780327968	399	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA7023552 rs749347270	402	F>Y		No	ClinGen ExAC gnomAD
CA7023553 rs768575041	403	L>V		No	ClinGen ExAC gnomAD
CA388683590 rs1428818511	405	M>K		No	ClinGen TOPMed
rs1369357269 CA388683587	405	M>L		No	ClinGen gnomAD
rs774172996 CA7023555	407	L>F		No	ClinGen ExAC TOPMed gnomAD
COSM198887 CA7023554 rs774172996	407	L>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7023557 rs368419692 COSM1514391	409	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA388683628 rs1176388967	410	Y>F		No	ClinGen TOPMed
rs1478351658 CA388683637	412	K>E		No	ClinGen TOPMed
TCGA novel	413	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7023559 rs766044434	415	F>L		No	ClinGen ExAC TOPMed gnomAD
CA7023560 rs776169163	416	Q>R		No	ClinGen ExAC gnomAD
rs758970533 CA7023561	417	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA388683682 COSM1210014 rs1482738025	418	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7023563 rs140922305	420	H>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764600252 CA7023562	420	H>Y		No	ClinGen ExAC gnomAD
CA7023565 rs757636802	425	L>V		No	ClinGen ExAC gnomAD
rs1251826397 CA388683752	428	Q>*		No	ClinGen gnomAD
CA388683761 rs1451913311	429	R>T		No	ClinGen gnomAD
CA388683771 rs1169728217	430	D>E		No	ClinGen gnomAD
CA7023566 rs374919031	431	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA388683774 rs374919031	431	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7023567 rs778619413	431	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7023571 rs755071265	434	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7023569 rs200597659	434	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7023572 rs778905293	435	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs866414186 CA255502015	435	R>W		No	ClinGen TOPMed gnomAD
rs955722946 CA255502016	436	E>G		No	ClinGen Ensembl
rs1225412009 CA388683810	437	E>G		No	ClinGen gnomAD
CA7023577 rs746839989	438	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7023576 rs772945372 COSM3376600	438	R>W	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs200033142 CA7023579	442	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
COSM1737652 CA7023580 rs562169523	442	R>Q	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs372992635 CA7023581	443	E>K		No	ClinGen ESP ExAC gnomAD
rs1466549772 CA388683849	444	H>P		No	ClinGen TOPMed
rs1166348555 CA388683852	444	H>Q		No	ClinGen gnomAD
rs1021841575 CA255502018	444	H>Y		No	ClinGen Ensembl
rs774890970 CA7023582	445	R>S		No	ClinGen ExAC gnomAD
CA388683861 rs768159623	446	D>A		No	ClinGen ExAC TOPMed gnomAD
rs1168730621 CA388683863	446	D>E		No	ClinGen TOPMed
CA388683862 rs768159623	446	D>G		No	ClinGen ExAC TOPMed gnomAD
rs762458089 CA7023583	446	D>H		No	ClinGen ExAC gnomAD
CA255502019 rs762458089	446	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	446	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768159623 CA7023584	446	D>V		No	ClinGen ExAC TOPMed gnomAD
rs202239358 CA7023585	447	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA388683874 rs1435633058	448	Q>E		No	ClinGen TOPMed gnomAD
CA7023586 rs756562993	450	P>T		No	ClinGen ExAC gnomAD
rs112912651 CA7023587	451	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778912839 CA7023590	453	D>G		No	ClinGen ExAC gnomAD
CA7023589 rs754076410	453	D>N		No	ClinGen ExAC gnomAD
CA7023588 rs754076410	453	D>Y		No	ClinGen ExAC gnomAD
CA7023591 rs748286220	454	G>E		No	ClinGen ExAC TOPMed gnomAD
CA388683914 rs1341090183	454	G>R		No	ClinGen gnomAD
CA7023592 rs758295331	455	A>T		No	ClinGen ExAC gnomAD
rs1331474154 CA388683941	458	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA388683943 rs1331474154	458	G>V		No	ClinGen gnomAD
rs200967296 CA7023593	459	T>A		No	ClinGen 1000Genomes ExAC gnomAD
COSM3384942 CA7023595 rs770768259	462	E>K	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA7023597 rs776338767	463	D>H		No	ClinGen ExAC
CA7023596 rs776338767	463	D>N		No	ClinGen ExAC
CA7023598 rs769325134	463	D>V		No	ClinGen ExAC gnomAD
CA388683968 rs776338767	463	D>Y		No	ClinGen ExAC
rs115169080 CA388684003	467	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs946154865 CA255502022	467	Q>L		No	ClinGen TOPMed gnomAD
rs907243781 CA255502023	470	R>K		No	ClinGen TOPMed gnomAD
rs1158201224 CA388684028	471	W>*		No	ClinGen TOPMed gnomAD

No associated diseases with Q8IZP7

No regional properties for Q8IZP7

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8IZP7

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name	Definition
heparan sulfate 6-O-sulfotransferase activity	Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate.

1 GO annotations of biological process

Name	Definition
heparan sulfate proteoglycan biosynthetic process, enzymatic modification	The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9QYK4	Hs6st3	Heparan-sulfate 6-O-sulfotransferase 3	Mus musculus (Mouse)	PR
Q3EDG5	TPST	Protein-tyrosine sulfotransferase	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MDERFNKWLL	TPVLTLLFVV	IMYQYVSPSC	TSSCTNFGEQ	PRAGEAGPPA	VPGPARRAQA
70	80	90	100	110	120
PPEEWERRPQ	LPPPPRGPPE	GPRGAAAPEE	EDEEPGDPRE	GEEEEEEDEP	DPEAPENGSL
130	140	150	160	170	180
PRFVPRFNFS	LKDLTRFVDF	NIKGRDVIVF	LHIQKTGGTT	FGRHLVKNIR	LEQPCSCKAG
190	200	210	220	230	240
QKKCTCHRPG	KKETWLFSRF	STGWSCGLHA	DWTELTNCVP	AIMEKKDCPR	NHSHTRNFYY
250	260	270	280	290	300
ITMLRDPVSR	YLSEWKHVQR	GATWKTSLHM	CDGRSPTPDE	LPTCYPGDDW	SGVSLREFMD
310	320	330	340	350	360
CTYNLANNRQ	VRMLADLSLV	GCYNLTFMNE	SERNTILLQS	AKNNLKNMAF	FGLTEFQRKT
370	380	390	400	410	420
QFLFERTFNL	KFISPFTQFN	ITRASNVEIN	EGARQRIEDL	NFLDMQLYEY	AKDLFQQRYH
430	440	450	460	470
HTKQLEHQRD	RQKRREERRL	QREHRDHQWP	KEDGAAEGTV	TEDYNSQVVR	W