Q9QYJ0

PR
Gene name
Dnaja2
Protein name
DnaJ homolog subfamily A member 2
Names
mDj3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:56445
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

342-412 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QYJ0

Entry ID Method Resolution Chain Position Source
AF-Q9QYJ0-F1 Predicted AlphaFoldDB

14 variants for Q9QYJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs13469334 62 K>R No EVA
rs3388997952 126 D>N No EVA
rs3413091429 227 H>Y No EVA
rs3388994905 239 Q>* No EVA
rs3388973918 243 V>M No EVA
rs3398925785 264 G>E No EVA
rs3388998481 292 R>L No EVA
rs3388995959 294 I>F No EVA
rs3388979404 300 P>L No EVA
rs3388994816 317 M>L No EVA
rs3388950629 359 P>L No EVA
rs3388991444 373 L>I No EVA
rs3388997942 409 C>Y No EVA
rs3388995961 411 H>Q No EVA

No associated diseases with Q9QYJ0

4 regional properties for Q9QYJ0

Type Name Position InterPro Accession
domain Heat shock protein DnaJ, cysteine-rich domain 130 - 214 IPR001305
domain DnaJ domain 7 - 81 IPR001623
domain Chaperone DnaJ, C-terminal 117 - 338 IPR002939
conserved_site DnaJ domain, conserved site 47 - 66 IPR018253

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
metal ion binding Binding to a metal ion.
unfolded protein binding Binding to an unfolded protein.

2 GO annotations of biological process

Name Definition
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60884 DNAJA2 DnaJ homolog subfamily A member 2 Homo sapiens (Human) PR
O35824 Dnaja2 DnaJ homolog subfamily A member 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI SFAYEVLSNP
70 80 90 100 110 120
EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM GNQSRSRNGR RRGEDMMHPL
130 140 150 160 170 180
KVSLEDLYNG KTTKLQLSKN VLCSACSGQG GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ
190 200 210 220 230 240
QMQSVCSDCN GEGEVINEKD RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA
250 260 270 280 290 300
PGVEPGDIVL LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD ARQIVVKYPP
310 320 330 340 350 360
GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE LEDLLPSRPE
370 380 390 400 410
VPNVIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS SHHGPGVQCA HQ