AiPD: Autoinhibited Protein Database

O60884

Gene name	DNAJA2 (CPR3, HIRIP4)
Protein name	DnaJ homolog subfamily A member 2
Names	Cell cycle progression restoration gene 3 protein, Dnj3, Dj3, HIRA-interacting protein 4, Renal carcinoma antigen NY-REN-14
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10294
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

350-412 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

350-412 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O60884

Entry ID	Method	Resolution	Chain	Position	Source
7ZHS	EM	690 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d	1-412	PDB
AF-O60884-F1	Predicted				AlphaFoldDB

227 variants for O60884

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395801632 rs1172131747	3	N>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1012402589 CA280205503	4	V>M		No	ClinGen TOPMed
CA395801614 rs1308939111	5	A>T		No	ClinGen TOPMed
CA8039310 rs759599179	7	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1457625363 CA395801478	14	G>S		No	ClinGen gnomAD
CA8039309 rs776717376	16	P>L		No	ClinGen ExAC TOPMed gnomAD
CA395801444 rs1460405490	17	P>T		No	ClinGen gnomAD
CA395801424 rs1219368770	18	G>S		No	ClinGen gnomAD
rs746914835 CA8039307	23	E>K		No	ClinGen ExAC gnomAD
rs1219927557 CA395800957	33	K>R		No	ClinGen gnomAD
rs1257939668 CA395800927	37	P>S		No	ClinGen TOPMed
TCGA novel	38	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1198196112 CA395800918	38	D>V		No	ClinGen gnomAD
rs1276373730 CA395800904	40	N>T		No	ClinGen gnomAD
TCGA novel	41	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202243022 CA8039280	42	N>D		No	ClinGen ExAC gnomAD
rs1233470053 CA395800877	44	G>E		No	ClinGen TOPMed
CA395800862 rs1456624777	46	K>R		No	ClinGen gnomAD
rs1238328042 CA395800796	50	I>K		No	ClinGen gnomAD
rs1238328042 CA395800794	50	I>T		No	ClinGen gnomAD
rs1274515946 CA395800801	50	I>V		No	ClinGen TOPMed
rs1403160739 CA395800785	51	S>G		No	ClinGen gnomAD
TCGA novel	52	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8039233 rs762799663	54	Y>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	55	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775094018 CA8039232	56	V>I		No	ClinGen ExAC gnomAD
TCGA novel	59	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	60	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317285538 CA395800638	60	P>R		No	ClinGen TOPMed
rs1002952512 CA280203801	60	P>T		No	ClinGen TOPMed
rs759070854 CA8039230	61	E>G		No	ClinGen ExAC gnomAD
CA395800582 rs1251966743 COSM1250434	63	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
rs776142209 CA395800547	65	L>F		No	ClinGen ExAC gnomAD
rs1379445095 CA395800503	68	R>K		No	ClinGen TOPMed gnomAD
TCGA novel CA395800495 rs1197667183	68	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
CA395800444 rs1479645246	72	Q>R		No	ClinGen TOPMed
rs997644710 CA280203777	74	L>V		No	ClinGen gnomAD
rs559641513 CA8039226	75	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8039227 rs748720169	75	R>W		No	ClinGen ExAC gnomAD
CA622644142 rs1482979639	76	E>K		No	ClinGen gnomAD
rs1347328345 CA395800389	78	S>G		No	ClinGen gnomAD
CA8039225 COSM122648 rs768986577	79	G>S	upper_aerodigestive_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA395800376 rs1308973501	80	G>R		No	ClinGen gnomAD
rs1398677162 CA395800348	84	M>R		No	ClinGen TOPMed
CA395800352 rs1241347835	84	M>V		No	ClinGen TOPMed gnomAD
rs780236961 CA8039223	85	D>E		No	ClinGen ExAC gnomAD
CA395800328 rs1259175873	87	I>V		No	ClinGen gnomAD
CA8039222 rs756377849	88	F>L		No	ClinGen ExAC gnomAD
CA8039221 rs750648975	89	S>A		No	ClinGen ExAC gnomAD
rs781464689 CA8039220	90	H>N		No	ClinGen ExAC gnomAD
CA395800302 rs1302433690	91	I>V		No	ClinGen gnomAD
CA280203716 rs1065332	93	G>C		No	ClinGen Ensembl
rs1359505968 CA395800286	93	G>D		No	ClinGen gnomAD
CA395800260 rs1410625322	97	F>S		No	ClinGen TOPMed
CA8039219 rs757412266	98	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA395800237 rs764110614 CA8039217	100	M>I		No	ClinGen ExAC TOPMed gnomAD
CA395800215 TCGA novel rs1596659397	103	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen Ensembl
TCGA novel	105	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280203699 rs143994918	107	R>Q		No	ClinGen ESP TOPMed
rs752569660 CA8039215	111	R>G		No	ClinGen ExAC gnomAD
CA395800120 rs1567355353	113	G>R		No	ClinGen Ensembl
CA8039212 rs776259550	117	M>I		No	ClinGen ExAC gnomAD
rs1596659377 CA395800018	119	P>L		No	ClinGen Ensembl
CA8039193 rs754752738	127	L>M		No	ClinGen ExAC gnomAD
rs370257555 CA8039192	129	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs766023911 CA8039191	132	T>A		No	ClinGen ExAC gnomAD
CA8039190 rs760275799	133	T>A		No	ClinGen ExAC TOPMed gnomAD
CA8039189 rs772796824	134	K>E		No	ClinGen ExAC
TCGA novel	134	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395798349 rs1380326014	137	L>R		No	ClinGen gnomAD
rs1045650 CA280200980	138	S>I		No	ClinGen ExAC gnomAD
rs1045650 CA8039186	138	S>N		No	ClinGen ExAC gnomAD
CA395798194 COSM1377958 rs1370357490	144	S>G	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs770342885 CA8039185	144	S>N		No	ClinGen ExAC TOPMed gnomAD
CA395798100 rs1300460916	147	S>G		No	ClinGen TOPMed
rs1329061310 CA395798088	147	S>I		No	ClinGen gnomAD
rs1329562193	148	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1400288716 CA395797840	151	G>R		No	ClinGen TOPMed gnomAD
rs1172183733 CA395797826	152	K>E		No	ClinGen gnomAD
CA8039167 rs751026855 CA395797808	152	K>N		No	ClinGen ExAC gnomAD
rs1177232448 CA395797752	155	A>V		No	ClinGen gnomAD
rs765847997 CA8039165	156	V>I		No	ClinGen ExAC gnomAD
rs563442946 CA8039162	161	A>T		No	ClinGen ExAC gnomAD
CA280200252 rs975623207	161	A>V		No	ClinGen TOPMed gnomAD
CA8039159 rs772277874	164	G>A		No	ClinGen ExAC gnomAD
rs1377492187 CA395797534	165	R>G		No	ClinGen gnomAD
CA395797526 rs1195784639	165	R>Q		No	ClinGen TOPMed
rs745927844 CA280200162	167	V>G		No	ClinGen Ensembl
CA280200150 rs140371161	168	R>C		No	ClinGen ESP TOPMed gnomAD
CA8039158 rs534125595	168	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8039157 rs779007173	169	I>V		No	ClinGen ExAC gnomAD
TCGA novel	170	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8039156 rs768603261	170	M>V		No	ClinGen ExAC gnomAD
rs1419501601 CA395797444	171	I>V		No	ClinGen gnomAD
CA395797384 rs1472121887	175	A>S		No	ClinGen gnomAD
rs1236367617 CA395797371	176	P>A		No	ClinGen gnomAD
rs750150488 CA8039152	183	Q>*		No	ClinGen ExAC gnomAD
CA395797118 rs1354113089	187	S>C		No	ClinGen gnomAD
rs1226522815 CA395797042	190	N>S		No	ClinGen TOPMed gnomAD
CA8039150 rs756868978	193	G>R		No	ClinGen ExAC gnomAD
CA395795680 rs1428676109	195	V>G		No	ClinGen gnomAD
rs866713385 CA280197566	196	I>V		No	ClinGen Ensembl
rs754457151 CA8039127	197	N>D		No	ClinGen ExAC
rs200039226 CA280197548	199	K>N		No	ClinGen Ensembl
CA8039126 rs372223991	201	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1189193637 CA395795625	201	R>H		No	ClinGen TOPMed gnomAD
rs1253435557 CA395795607	204	K>E		No	ClinGen gnomAD
TCGA novel	204	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756600565 CA8039125	204	K>R		No	ClinGen ExAC gnomAD
CA395795581 rs1456431922	205	C>W		No	ClinGen gnomAD
rs1256226961 CA395795555	207	G>E		No	ClinGen gnomAD
CA395795526 rs1198090542	209	K>R		No	ClinGen gnomAD
rs750771069 CA8039124	212	K>E		No	ClinGen ExAC
CA280197491 rs766635225	213	E>D		No	ClinGen Ensembl
CA280197489 rs1017561265	217	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA395795316 rs1567353667	218	E>K		No	ClinGen Ensembl
CA8039121 rs373625818	221	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA395795228 rs1217734396	222	D>H		No	ClinGen gnomAD
rs764214828 CA8039120	225	M>V		No	ClinGen ExAC gnomAD
CA395795053 rs1304702821	228	G>E		No	ClinGen gnomAD
CA395795038 rs1198303547	229	Q>R		No	ClinGen TOPMed
CA395795011 rs1412531961	230	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	236	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8039118 rs775483729	237	A>G		No	ClinGen ExAC gnomAD
rs1596656356 CA395794884	237	A>T		No	ClinGen Ensembl
CA280197445 rs952164476	239	Q>E		No	ClinGen Ensembl
rs551335479 CA8039116	240	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA280197423 rs1027691927	243	V>M		No	ClinGen gnomAD
rs746728501 CA395794726	245	P>A		No	ClinGen ExAC gnomAD
rs746728501 CA8039113	245	P>S		No	ClinGen ExAC gnomAD
rs746728501 CA280197381	245	P>T		No	ClinGen ExAC gnomAD
rs758054922 CA8039111	247	D>N		No	ClinGen ExAC gnomAD
CA280197368 rs770291135	248	I>V		No	ClinGen TOPMed
rs1567353633 CA395794599	253	Q>R		No	ClinGen Ensembl
CA395794522 rs1429439687	257	H>D		No	ClinGen TOPMed
rs1477284730 CA395794516	257	H>R		No	ClinGen TOPMed
CA395793783 rs1258516207	259	V>A		No	ClinGen gnomAD
CA8039095 rs759436802	259	V>I		No	ClinGen ExAC gnomAD
CA280193426 rs1043138703	261	Q>K		No	ClinGen Ensembl
rs746816378 CA8039092	269	M>V		No	ClinGen ExAC gnomAD
CA395793705 rs1567352595	270	T>A		No	ClinGen Ensembl
rs773099184 CA8039091	270	T>I		No	ClinGen ExAC TOPMed gnomAD
CA8039089 rs747776623	271	Y>C		No	ClinGen ExAC gnomAD
rs771871433 CA8039090	271	Y>H		No	ClinGen ExAC gnomAD
rs1355657311 CA395793676	274	G>A		No	ClinGen TOPMed gnomAD
rs754505395 CA8039087	276	V>A		No	ClinGen ExAC gnomAD
CA8039088 rs199942539	276	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8039086 rs746419116	278	A>V		No	ClinGen ExAC gnomAD
rs1342837196 CA395793648	279	L>P		No	ClinGen gnomAD
CA280193379 rs750109124	284	F>L		No	ClinGen Ensembl
rs1366661580 CA395793585	286	F>L		No	ClinGen gnomAD
CA395793562 rs1468476162	288	H>Y		No	ClinGen TOPMed
rs1258365140 CA395793529	290	D>G		No	ClinGen gnomAD
rs758668893 CA280193362	291	G>A		No	ClinGen ExAC TOPMed gnomAD
CA8039081 rs758668893	291	G>V		No	ClinGen ExAC TOPMed gnomAD
CA8039079 rs765303923	292	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8039078 rs759651150	294	I>T		No	ClinGen ExAC gnomAD
CA280193331 rs776422953	295	V>L		No	ClinGen Ensembl
CA8039075 rs760638193 COSM1686234	300	P>L	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs766369059 CA8039076	300	P>S		No	ClinGen ExAC gnomAD
CA395793391 rs1406981810	301	G>S		No	ClinGen gnomAD
TCGA novel	301	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773186891 CA8039074	302	K>N		No	ClinGen ExAC gnomAD
rs1394258106 CA395793385	302	K>Q		No	ClinGen gnomAD
rs1034831455 CA280193324	302	K>R		No	ClinGen TOPMed gnomAD
CA8039073 rs771957552	306	P>R		No	ClinGen ExAC gnomAD
TCGA novel	307	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767478496 CA8039049	308	C>Y		No	ClinGen ExAC gnomAD
rs1257117890 CA395793250	311	V>I		No	ClinGen TOPMed
CA395793233 rs1436518027	312	V>D		No	ClinGen TOPMed gnomAD
CA395793216 rs1257961632	313	R>L		No	ClinGen TOPMed gnomAD
rs1257961632 CA395793221	313	R>Q		No	ClinGen TOPMed gnomAD
CA8039048 rs377422570	317	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8039047 rs773950249 COSM3771949	318	P>L	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1320409451 CA395793137	318	P>S		No	ClinGen gnomAD
rs1320409451 CA395793142	318	P>T		No	ClinGen gnomAD
rs768387409 CA395793119	319	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs768387409 CA8039046	319	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA395793078 rs1455043292	321	R>H		No	ClinGen TOPMed gnomAD
rs1366511695 CA622580805	322	N>*		No	ClinGen gnomAD
rs1433229914 CA395793054	323	P>T		No	ClinGen TOPMed
CA280193102 rs1049292742	326	K>R		No	ClinGen TOPMed gnomAD
CA280193097 rs369080423	330	Y>H		No	ClinGen ESP TOPMed
CA8039045 rs762465852	331	I>M		No	ClinGen ExAC gnomAD
CA395792836 rs1274857452	334	D>E		No	ClinGen TOPMed gnomAD
CA280193096 rs891852246 CA395792807	336	Q>H		No	ClinGen TOPMed gnomAD
CA8039042 rs200198931	340	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395792742 rs200198931	340	N>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780937485 CA280193085	342	W>G		No	ClinGen Ensembl
rs1330588674 CA395792674	343	I>T		No	ClinGen gnomAD
rs772512918 CA8039040	344	N>I		No	ClinGen ExAC gnomAD
rs1234760927 CA395792647	345	P>T		No	ClinGen gnomAD
CA8039039 rs748554053	347	K>R		No	ClinGen ExAC gnomAD
CA395792592 rs1307028879	348	L>F		No	ClinGen gnomAD
TCGA novel	349	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8039021 rs772601096	350	E>G		No	ClinGen ExAC gnomAD
rs774815723 CA8039019	358	R>G		No	ClinGen ExAC gnomAD
CA8039018 rs768894461	359	P>A		No	ClinGen ExAC TOPMed gnomAD
CA8039017 rs749578018	359	P>L		No	ClinGen ExAC TOPMed gnomAD
CA395791515 rs749578018	359	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1409372001 CA395791433	363	N>D		No	ClinGen TOPMed gnomAD
rs745975632 CA8039014	364	I>T		No	ClinGen ExAC gnomAD
CA8039015 rs756336225	364	I>V		No	ClinGen ExAC gnomAD
rs1416574572 CA395791362	366	G>R		No	ClinGen gnomAD
CA8039012 rs757270298	368	T>R		No	ClinGen ExAC gnomAD
TCGA novel	369	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1214828452 CA395791224	371	V>L		No	ClinGen gnomAD
CA395791170 rs908391216	372	E>D		No	ClinGen gnomAD
TCGA novel	375	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1286297259 CA395791051	376	F>L		No	ClinGen gnomAD
CA395790942 rs1179785284	380	R>G		No	ClinGen TOPMed gnomAD
CA8039011 rs751421502	380	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	381	G>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8039009 rs758118666	382	S>T		No	ClinGen ExAC gnomAD
rs200288545 CA8039007	388	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1287426031 CA395790782	389	E>K		No	ClinGen gnomAD
CA8039005 rs376667429	390	A>S		No	ClinGen ESP ExAC gnomAD
CA8039004 rs765773216	394	S>G		No	ClinGen ExAC gnomAD
CA8039003 rs762444482	395	S>C		No	ClinGen ExAC gnomAD
CA395790599 rs1293016816	400	S>G		No	ClinGen TOPMed
rs769147675 CA8039001	400	S>N		No	ClinGen ExAC gnomAD
rs1488148044 CA395790581	402	H>R		No	ClinGen TOPMed
rs1416979922 CA395790583	402	H>Y		No	ClinGen gnomAD
rs991599545 CA280191775	403	H>Q		No	ClinGen TOPMed gnomAD
CA280191776 rs915829591	403	H>R		No	ClinGen TOPMed
rs1475601525 CA395790560	405	P>R		No	ClinGen gnomAD

No associated diseases with O60884

2 regional properties for O60884

Type	Name	Position	InterPro Accession
domain	Bromodomain associated domain	31 - 108	IPR006565
domain	Transcription factor TFIID, subunit 8, C-terminal	146 - 199	IPR019473

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase activator activity	Binds to and increases the activity of an ATP hydrolysis activity.
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
metal ion binding	Binding to a metal ion.
unfolded protein binding	Binding to an unfolded protein.

3 GO annotations of biological process

Name	Definition
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
protein refolding	The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
response to heat	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9QYJ0	Dnaja2	DnaJ homolog subfamily A member 2	Mus musculus (Mouse)	PR
O35824	Dnaja2	DnaJ homolog subfamily A member 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MANVADTKLY	DILGVPPGAS	ENELKKAYRK	LAKEYHPDKN	PNAGDKFKEI	SFAYEVLSNP
70	80	90	100	110	120
EKRELYDRYG	EQGLREGSGG	GGGMDDIFSH	IFGGGLFGFM	GNQSRSRNGR	RRGEDMMHPL
130	140	150	160	170	180
KVSLEDLYNG	KTTKLQLSKN	VLCSACSGQG	GKSGAVQKCS	ACRGRGVRIM	IRQLAPGMVQ
190	200	210	220	230	240
QMQSVCSDCN	GEGEVINEKD	RCKKCEGKKV	IKEVKILEVH	VDKGMKHGQR	ITFTGEADQA
250	260	270	280	290	300
PGVEPGDIVL	LLQEKEHEVF	QRDGNDLHMT	YKIGLVEALC	GFQFTFKHLD	GRQIVVKYPP
310	320	330	340	350	360
GKVIEPGCVR	VVRGEGMPQY	RNPFEKGDLY	IKFDVQFPEN	NWINPDKLSE	LEDLLPSRPE
370	380	390	400	410
VPNIIGETEE	VELQEFDSTR	GSGGGQRREA	YNDSSDEESS	SHHGPGVQCA	HQ