Q9QY01
Gene name |
Ulk2 (Kiaa0623) |
Protein name |
Serine/threonine-protein kinase ULK2 |
Names |
Serine/threonine-protein kinase Unc51.2, Unc-51-like kinase 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:29869 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
157-179 (Activation loop from InterPro)
Target domain |
9-271 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q9QY01
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QY01-F1 | Predicted | AlphaFoldDB |
24 variants for Q9QY01
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389163660 | 113 | H>Y | No | EVA | |
| rs3389135886 | 123 | H>Q | No | EVA | |
| rs3389151904 | 167 | S>I | No | EVA | |
| rs3389140128 | 205 | Y>H | No | EVA | |
| rs3401714462 | 236 | I>V | No | EVA | |
| rs3389168273 | 274 | V>I | No | EVA | |
| rs3389177469 | 356 | V>D | No | EVA | |
| rs3389163305 | 420 | T>S | No | EVA | |
| rs3389128656 | 453 | S>F | No | EVA | |
| rs26955148 | 501 | A>D | No | EVA | |
| rs3389171994 | 528 | S>N | No | EVA | |
| rs3389159212 | 569 | G>D | No | EVA | |
| rs225859317 | 629 | A>P | No | EVA | |
| rs3402365619 | 649 | Q>L | No | EVA | |
| rs3389168313 | 731 | P>S | No | EVA | |
| rs3389128672 | 734 | S>G | No | EVA | |
| rs3389166302 | 768 | V>I | No | EVA | |
| rs3389140144 | 770 | V>L | No | EVA | |
| rs3389168304 | 784 | G>VSDG* | No | EVA | |
| rs241044052 | 787 | G>A | No | EVA | |
| rs3389102655 | 788 | A>V | No | EVA | |
| rs3389140079 | 807 | I>V | No | EVA | |
| rs3389171980 | 818 | T>K | No | EVA | |
| rs263131109 | 944 | N>S | No | EVA |
No associated diseases with Q9QY01
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| phagophore assembly site membrane | A cellular membrane associated with the phagophore assembly site. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| axon extension | Long distance growth of a single axon process involved in cellular development. |
| collateral sprouting | The process in which outgrowths develop from the shafts of existing axons. |
| late nucleophagy | A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. |
| negative regulation of collateral sprouting | Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| piecemeal microautophagy of the nucleus | Degradation of a cell nucleus by lysosomal microautophagy. |
| positive regulation of autophagy | Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
| reticulophagy | The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53104 | ATG1 | Serine/threonine-protein kinase ATG1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q6PHR2 | ULK3 | Serine/threonine-protein kinase ULK3 | Homo sapiens (Human) | PR |
| Q3U3Q1 | Ulk3 | Serine/threonine-protein kinase ULK3 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVVGDFEYC | KRDLVGHGAF | AVVFRGRHRQ | KTDWEVAIKS | INKKNLSKSQ | ILLGKEIKIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KELQHENIVA | LYDVQELPNS | VFLVMEYCNG | GDLADYLQAK | GTLSEDTIRV | FLHQIAAAMR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILHSKGIIHR | DLKPQNILLS | YANRRKSNVS | GIRIKIADFG | FARYLHSNTM | AATLCGSPMY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MAPEVIMSQH | YDAKADLWSI | GTVIYQCLVG | KPPFQANSPQ | DLRMFYEKNR | SLMPSIPRET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPYLANLLLG | LLQRNQKDRM | DFEAFFSHPF | LEQVPVKKSC | PVPVPVYSGP | VPGSSCSSSP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SCRFASPPSL | PDMQHIQEEN | LSSPPLGPPN | YLQVSKDSAS | NSSKNSSCDT | DDFVLVPHNI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSDHSYDMPM | GTTARRASNE | FFMCGGQCQP | TVSPHSETAP | IPVPTQVRNY | QRIEQNLIST |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ASSGTNPHGS | PRSAVVRRSN | TSPMGFLRVG | SCSPVPGDTV | QTGGRRLSTG | SSRPYSPSPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VGTIPEQFSQ | CCCGHPQGHE | ARSRHSSGSP | VPQTQAPQSL | LLGARLQSAP | TLTDIYQNKQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLRKQHSDPV | CPSHAGAGYS | YSPQPSRPGS | LGTSPTKHTG | SSPRNSDWFF | KTPLPTIIGS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PTKTTAPFKI | PKTQASSNLL | ALVTRHGPAE | SQSKDGNDPR | ECSHCLSVQG | SERHRSEQQQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SKAVFGRSVS | TGKLSEQQVK | APLGGHQGST | DSLNTERPMD | VAPAGACGVM | LALPAGTAAS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ARAVLFTVGS | PPHSATAPTC | THMVLRTRTT | SVGSSSSGGS | LCSASGRVCV | GSPPGPGLGS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SPPGAEGAPS | LRYVPYGASP | PSLEGLITFE | APELPEETLM | EREHTDTLRH | LNMMLMFTEC |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VLDLTAVRGG | NPELCTSAVS | LYQIQESVVV | DQISQLSKDW | GRVEQLVLYM | KAAQLLAASL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HLAKAQVKSG | KLSPSMAVKQ | VVKNLNERYK | FCITMCKKLT | EKLNRFFSDK | QRFIDEINSV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TAEKLIYNCA | VEMVQSAALD | EMFQQTEDIV | YRYHKAALLL | EGLSKILQDP | TDVENVHKYK |
| 1030 | |||||
| CSIERRLSAL | CCSTATV |