AiPD: Autoinhibited Protein Database

Q9NYH9

Gene name	UTP6 (C17orf40, HCA66, MHAT)
Protein name	U3 small nucleolar RNA-associated protein 6 homolog
Names	Hepatocellular carcinoma-associated antigen 66, Multiple hat domains protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55813
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

162-237 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

162-237 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9NYH9

Entry ID	Method	Resolution	Chain	Position	Source
7MQ8	EM	360 A	LP	1-597	PDB
7MQ9	EM	387 A	LP	1-597	PDB
7MQA	EM	270 A	LP	1-597	PDB
AF-Q9NYH9-F1	Predicted				AlphaFoldDB

480 variants for Q9NYH9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs765670263 CA8489429	6	Q>E		No	ClinGen ExAC gnomAD
CA8489428 rs759333649	8	R>C		No	ClinGen ExAC gnomAD
rs1364565354 CA399024218	9	I>M		No	ClinGen TOPMed
CA289396224 rs541116440	9	I>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489425 rs541116440	9	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489426 rs766002275	9	I>V		No	ClinGen ExAC gnomAD
rs1164104731 CA399024215	10	E>Q		No	ClinGen gnomAD
CA8489424 rs772739532	11	D>Y		No	ClinGen ExAC gnomAD
rs771926093 CA399024165	14	P>L		No	ClinGen ExAC gnomAD
rs771926093 CA8489423	14	P>R		No	ClinGen ExAC gnomAD
CA399024166 rs1263172853	14	P>S		No	ClinGen gnomAD
rs1157058614 CA399024126	17	E>D		No	ClinGen TOPMed
rs1228561173 CA399024139	17	E>K		No	ClinGen gnomAD
rs1339207643 CA399024075	21	R>C		No	ClinGen TOPMed
CA399024071 rs1401672977	21	R>H		No	ClinGen TOPMed gnomAD
CA399024068 rs1401672977	21	R>L		No	ClinGen TOPMed gnomAD
CA8489421 rs199526310	22	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1340887520 CA399024062	22	I>V		No	ClinGen gnomAD
rs746145090 CA8489419	23	G>R		No	ClinGen ExAC TOPMed gnomAD
rs113076339 CA289396197	24	L>P		No	ClinGen Ensembl
CA289396200 rs953817706	24	L>V		No	ClinGen TOPMed
CA8489418 COSM1197377 rs555281395	25	F>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs771116748 CA8489417	27	H>D		No	ClinGen ExAC TOPMed gnomAD
CA399024004 rs1411829153	27	H>L		No	ClinGen gnomAD
CA8489416 rs747087699	27	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA8489415 rs542176758	28	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489414 rs758874849	29	E>Q		No	ClinGen ExAC gnomAD
rs1490971920 CA399023981	30	I>L		No	ClinGen gnomAD
CA8489392 rs76761783	32	A>S		No	ClinGen ExAC gnomAD
rs969747057 CA289394646	33	I>F		No	ClinGen TOPMed
rs1437692905 CA399023406	34	I>L		No	ClinGen TOPMed
rs755763826 CA8489391	34	I>M		No	ClinGen ExAC TOPMed gnomAD
CA399023389 rs1324353190	35	K>E		No	ClinGen TOPMed
VAR_031222 RCV000966508 rs16967042 CA8489390	35	K>R		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA399023383 rs16967042	35	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1265526094 CA399023376	36	K>E		No	ClinGen TOPMed
rs769100071 CA289394627	37	A>G		No	ClinGen gnomAD
CA289394624 rs267604798	38	S>F		No	ClinGen Ensembl
CA8489386 rs1555577717	39	D>N		No	ClinGen Ensembl
rs1598123966 CA399023327	40	L>V		No	ClinGen Ensembl
CA8489385 rs751002439	41	E>G		No	ClinGen ExAC gnomAD
rs1598123956 CA399023288	43	K>R		No	ClinGen Ensembl
CA399023268 rs1567796190	44	I>M		No	ClinGen Ensembl
CA399023250 rs1272442613	46	R>G		No	ClinGen TOPMed
CA399023231 rs1465221378	47	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA289394619 rs111969582	48	T>A		No	ClinGen Ensembl
CA8489383 rs146195806	49	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs146195806 CA8489384	49	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs377073088 CA8489382	51	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8489381 rs377073088	51	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA289394566 rs932115686	51	K>R		No	ClinGen Ensembl
rs760868998 CA8489380	52	E>G		No	ClinGen ExAC TOPMed gnomAD
CA289394556 rs903314050	52	E>K		No	ClinGen TOPMed
CA289394533 rs535101116	54	F>L		No	ClinGen TOPMed
CA289394529 rs1037644709	55	I>N		No	ClinGen Ensembl
CA8489360 rs759383567	62	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8489358 rs576422881	66	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8489357 rs762106393	69	Q>*		No	ClinGen ExAC gnomAD
rs768852358 CA8489355	69	Q>H		No	ClinGen ExAC gnomAD
rs3760454 CA399022122	69	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs3760454 CA399022123	69	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_026668 rs3760454 CA8489356	69	Q>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA289391028 rs113806075	70	R>G		No	ClinGen Ensembl
TCGA novel	70	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763429393 CA8489354	72	R>T		No	ClinGen ExAC gnomAD
CA399022061 rs1168154867	73	T>I		No	ClinGen TOPMed
CA8489339 rs201848137	74	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM977537 rs762194464 CA8489338	74	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA399022000 rs201848137	74	R>S		No	ClinGen ExAC TOPMed gnomAD
CA289390905 rs536396320	75	I>T		No	ClinGen Ensembl
rs751818861 CA8489337	75	I>V		No	ClinGen ExAC TOPMed gnomAD
CA289390899 rs994443622	77	Y>S		No	ClinGen gnomAD
rs1243313170 CA399021918	78	S>*		No	ClinGen TOPMed
CA8489335 rs763098162	78	S>P		No	ClinGen ExAC gnomAD
CA399021910 rs1278749239	79	F>L		No	ClinGen gnomAD
rs1171039167 CA399021829	82	D>E		No	ClinGen TOPMed gnomAD
rs1402227779 CA399021842	82	D>Y		No	ClinGen gnomAD
TCGA novel	83	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8489331 rs202236562	88	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs531652947 CA8489330	88	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489332 rs202236562	88	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8489329 rs771277196	89	V>L		No	ClinGen ExAC gnomAD
CA399021649 rs1459228968	90	H>Q		No	ClinGen gnomAD
CA399021663 rs1212081040	90	H>Y		No	ClinGen gnomAD
rs775119896 CA399021641	91	R>L		No	ClinGen ExAC TOPMed gnomAD
rs775119896 CA8489327	91	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8489328 rs746719051	91	R>W		No	ClinGen ExAC gnomAD
CA8489326 rs771588562	92	V>L		No	ClinGen ExAC gnomAD
rs1234574561 CA399021510	97	Q>H		No	ClinGen gnomAD
CA399021503 rs1331197576	98	R>C		No	ClinGen gnomAD
rs1299938494 CA399021494	98	R>H		No	ClinGen TOPMed gnomAD
COSM223867 rs747717916 CA8489324	99	A>T	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1378580837 CA399021479	99	A>V		No	ClinGen gnomAD
rs1337638253 CA399021464	100	S>L		No	ClinGen TOPMed
CA399021453 rs1331597316	101	A>E		No	ClinGen gnomAD
rs1394034886 CA399021414	103	W>C		No	ClinGen gnomAD
rs778267043 CA8489323	103	W>G		No	ClinGen ExAC gnomAD
rs1309588184 COSM1382254 CA399020784	106	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs777105019 CA8489311	110	W>R		No	ClinGen ExAC gnomAD
CA289389434 rs374174017	113	Y>C		No	ClinGen ESP gnomAD
rs374174017 CA399020585	113	Y>F		No	ClinGen ESP gnomAD
rs1401340374 CA399020611	113	Y>N		No	ClinGen TOPMed gnomAD
CA399020553 rs1380972169	115	A>V		No	ClinGen gnomAD
CA399020523 rs1158293002	117	C>S		No	ClinGen gnomAD
rs566763795 CA8489308	120	W>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399020423 rs566763795	120	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771809602 CA8489307	120	W>S		No	ClinGen ExAC gnomAD
rs1000788390 CA289389081	121	A>G		No	ClinGen TOPMed gnomAD
CA399020323 rs1000788390	121	A>V		No	ClinGen TOPMed gnomAD
CA8489290 rs773668903	122	T>N		No	ClinGen ExAC gnomAD
rs761150467 CA8489291	122	T>S		No	ClinGen ExAC gnomAD
rs767769935 CA8489288	124	T>N		No	ClinGen ExAC
CA399020255 rs1598116347	125	R>*		No	ClinGen Ensembl
rs149514713 CA399020234	125	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs149514713 CA8489287	125	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8489286 rs773891073	126	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA399020185 rs1598116326	129	V>G		No	ClinGen Ensembl
rs768289161 CA8489285	130	F>S		No	ClinGen ExAC gnomAD
CA8489284 rs748837752	132	A>T		No	ClinGen ExAC gnomAD
CA8489283 rs775090242	133	M>I		No	ClinGen ExAC TOPMed gnomAD
VAR_049322 rs34859443 CA8489281	134	L>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs781104096 CA8489280	134	L>W		No	ClinGen ExAC TOPMed gnomAD
CA8489279 rs756984797 COSM977536	135	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1324514348 CA399020045	139	N>S		No	ClinGen TOPMed gnomAD
rs1404937381 CA399020016	141	P>L		No	ClinGen gnomAD
rs749511728 CA399019981	142	A>D		No	ClinGen ExAC TOPMed gnomAD
CA8489277 rs201757154	142	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs749511728 CA8489255	142	A>V		No	ClinGen ExAC TOPMed gnomAD
CA399019977 rs1250822828	143	L>*		No	ClinGen gnomAD
rs201254967 CA8489254	144	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1458086705 CA399019959	145	I>T		No	ClinGen gnomAD
CA289386950 rs756200648	146	M>L		No	ClinGen ExAC gnomAD
CA8489253 rs756200648	146	M>V		No	ClinGen ExAC gnomAD
CA8489252 rs750452979	148	A>G		No	ClinGen ExAC TOPMed gnomAD
CA289386931 rs368540886	148	A>T		No	ClinGen ESP TOPMed
CA399019941 rs750452979	148	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	150	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195318890 CA399019919	151	E>G		No	ClinGen TOPMed
CA399019912 rs1279443362	152	M>K		No	ClinGen gnomAD
rs1313817039 CA399019914	152	M>V		No	ClinGen gnomAD
rs139868836 CA8489251	155	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8489250 rs139868836	155	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs922137873 CA289386925	155	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs751917028 CA8489249	157	S>F		No	ClinGen ExAC gnomAD
CA8489248 rs764522075	159	E>Q		No	ClinGen ExAC gnomAD
CA8489246 rs188357533	161	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758970653 CA8489244	162	R>G		No	ClinGen ExAC TOPMed gnomAD
rs776164884 CA8489243	163	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA8489242 rs770826025	163	Q>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	164	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141480679 CA8489238	167	R>C		No	ClinGen ESP ExAC gnomAD
rs780260167 CA8489237	167	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs199527189 CA8489235	168	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489233 rs199527189	168	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489234 rs199527189 COSM977535	168	A>T	Variant assessed as Somatic; 4.635e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs747546566 CA8489232	168	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8489231 rs138291704	170	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8489230 rs200732643	170	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753040642 CA8489229	171	F>C		No	ClinGen ExAC gnomAD
rs1241148967 CA399019803	171	F>L		No	ClinGen gnomAD
rs765010529 CA8489228	173	P>L		No	ClinGen ExAC gnomAD
rs754607083 CA8489227	174	E>*		No	ClinGen ExAC
rs1403627483 CA399019773	175	C>Y		No	ClinGen gnomAD
rs1261686753 CA399019766	176	P>L		No	ClinGen TOPMed
rs1567789869 CA399019759	177	K>R		No	ClinGen Ensembl
rs1230451939 CA399019749	179	Y>H		No	ClinGen gnomAD
CA8489213 rs147043256	182	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399019707 rs1453931585	183	F>L		No	ClinGen TOPMed
TCGA novel	184	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399019686 rs1450060522	185	M>I		No	ClinGen TOPMed
CA399019692 rs1380982417	185	M>V		No	ClinGen TOPMed
CA289385083 rs201293446	188	M>V		No	ClinGen 1000Genomes
rs569017892 CA8489210	189	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399019661 rs1286810506	189	H>R		No	ClinGen TOPMed gnomAD
rs569017892 CA8489211	189	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489207 rs753520031	194	R>T		No	ClinGen ExAC
CA8489206 rs765893871	195	K>R		No	ClinGen ExAC gnomAD
rs755655166 CA8489205	197	K>E		No	ClinGen ExAC
CA8489201 rs142388164 CA8489202	197	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8489203 rs151277876	197	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200394185 CA289385017	198	E>A		No	ClinGen 1000Genomes
CA8489199 rs774169826	203	A>G		No	ClinGen ExAC gnomAD
rs763943203 CA8489198	204	S>G		No	ClinGen ExAC gnomAD
rs1193177000 CA399019559 COSM4151578	204	S>N	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA399019558 rs1193177000	204	S>T		No	ClinGen TOPMed gnomAD
CA289385013 rs916073352	205	M>I		No	ClinGen TOPMed
rs1183285584 CA399019549	205	M>R		No	ClinGen TOPMed
rs759734872 CA8489197	206	D>N		No	ClinGen ExAC gnomAD
rs1378874449	208	E>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs972855138 CA289384288	209	N>Y		No	ClinGen TOPMed
CA8489179 rs763880502	210	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8489178 rs762808353	212	Y>D		No	ClinGen ExAC gnomAD
rs752391329 CA8489177	214	E>G		No	ClinGen ExAC gnomAD
TCGA novel	215	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8489176 rs536034624	215	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA8489175 rs536034624	215	E>V		No	ClinGen 1000Genomes ExAC gnomAD
rs773495912 CA8489174	218	K>E		No	ClinGen ExAC TOPMed gnomAD
CA399019441 rs113683685	220	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000966507 CA8489171 rs113683685	220	E>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs113683685 CA289384224	220	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399019426 rs1364749050	222	A>T		No	ClinGen gnomAD
CA399019414 rs1423571216	223	W>C		No	ClinGen TOPMed
CA399019395 rs1353347641	226	Y>C		No	ClinGen TOPMed gnomAD
rs780261219 CA8489168	229	S>F		No	ClinGen ExAC gnomAD
rs769478212 CA8489167	231	S>N		No	ClinGen ExAC TOPMed gnomAD
rs375397400 CA8489166	232	I>L		No	ClinGen ESP ExAC gnomAD
rs780736639 CA8489165	232	I>M		No	ClinGen ExAC gnomAD
rs1373303263 CA399019355	232	I>T		No	ClinGen TOPMed
rs375397400 CA399019356	232	I>V		No	ClinGen ESP ExAC gnomAD
rs1238146960 CA399019336	235	G>C		No	ClinGen gnomAD
CA8489148 rs775987500	235	G>V		No	ClinGen ExAC gnomAD
rs372541961 CA289383226	236	A>T		No	ClinGen ESP TOPMed gnomAD
rs770128832 CA399019291	239	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA399019288 rs1458362319	240	V>E		No	ClinGen gnomAD
CA8489146 rs746173324	240	V>M		No	ClinGen ExAC TOPMed gnomAD
rs776269928 CA8489145	241	S>L		No	ClinGen ExAC gnomAD
rs146623373 CA8489144	244	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs146623373 CA399019265	244	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs539855524 CA289383202	246	A>P		No	ClinGen Ensembl
rs1346507958 CA399019247	247	Q>R		No	ClinGen TOPMed
CA8489142 rs777121935	248	L>V		No	ClinGen ExAC gnomAD
TCGA novel	249	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs903674967 CA289383200	253	K>R		No	ClinGen Ensembl
CA8489141 rs758399480	254	D>G		No	ClinGen ExAC gnomAD
CA289383193 rs1043551907	254	D>N		No	ClinGen Ensembl
CA8489140 rs748025691	255	L>V		No	ClinGen ExAC gnomAD
rs1598109131 CA399019184	257	K>E		No	ClinGen Ensembl
CA289383162 rs201823042	257	K>R		No	ClinGen 1000Genomes
CA399019174 rs1274644870	258	E>A		No	ClinGen gnomAD
rs1350105759 CA399018945	263	L>P		No	ClinGen gnomAD
rs1304509988 CA399018940	264	Q>R		No	ClinGen gnomAD
rs1233784797 CA399018932	265	A>D		No	ClinGen TOPMed gnomAD
rs771498680 CA8489122	266	L>V		No	ClinGen ExAC gnomAD
rs371147186 CA8489121	267	H>P		No	ClinGen ESP ExAC gnomAD
TCGA novel	274	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754915003 CA8489119	276	Y>F		No	ClinGen ExAC gnomAD
CA8489117 rs779965805	280	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs865807343 CA289431741	280	R>L		No	ClinGen Ensembl
CA399018831 rs1396308013	281	E>K		No	ClinGen gnomAD
rs147328342 CA8489116	282	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA8489115 rs751716191	283	E>A		No	ClinGen ExAC TOPMed gnomAD
rs764318037 CA8489114	283	E>D		No	ClinGen ExAC gnomAD
CA399018818 rs1393051453	283	E>K		No	ClinGen gnomAD
CA8489113 rs200620009	287	Q>R		No	ClinGen ExAC gnomAD
CA8489112 rs752733689	288	T>A		No	ClinGen ExAC gnomAD
CA399018741 rs1486708647	291	Q>*		No	ClinGen gnomAD
CA399018743 rs1486708647	291	Q>K		No	ClinGen gnomAD
rs1281082485 CA399018733	292	P>A		No	ClinGen gnomAD
rs976553577 CA289431712	292	P>L		No	ClinGen TOPMed gnomAD
rs765751480 CA8489111	294	T>A		No	ClinGen ExAC gnomAD
CA399018706 rs963904092	294	T>M		No	ClinGen TOPMed gnomAD
CA289431701 rs963904092	294	T>R		No	ClinGen TOPMed gnomAD
rs1373019655 CA399018660	296	Q>H		No	ClinGen gnomAD
CA8489110 rs201014530	297	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1261722034 CA399018647	297	A>V		No	ClinGen TOPMed
rs777017028 CA8489109	299	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1018187555 CA289431693	300	V>M		No	ClinGen TOPMed
rs1005508284 CA289431686	301	E>V		No	ClinGen TOPMed
CA8489107 rs761044698	303	G>S		No	ClinGen ExAC TOPMed gnomAD
CA399018537 rs201792460	304	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8489105 rs201792460	304	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8489106 rs772746694	304	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1406916928 CA399018495	306	E>V		No	ClinGen gnomAD
rs139786553 CA289431638	307	E>D		No	ClinGen ESP
CA289431640 rs1008206497	307	E>G		No	ClinGen TOPMed gnomAD
CA8489104 rs761255705	309	C>G		No	ClinGen ExAC gnomAD
CA8489103 rs146176883	312	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA728072134 rs1251478204	313	Y>*		No	ClinGen Ensembl
rs780055608 CA8489100	317	V>G		No	ClinGen ExAC TOPMed gnomAD
CA8489099 rs769487517	318	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1316727219 CA399018282	319	T>A		No	ClinGen gnomAD
CA289431577 rs1046142079	321	P>A		No	ClinGen TOPMed
rs929454315 CA289431569	321	P>L		No	ClinGen Ensembl
CA8489097 rs542178063	323	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs762580181 CA8489067	325	M>I		No	ClinGen ExAC gnomAD
rs763771062 CA8489068	325	M>T		No	ClinGen ExAC TOPMed gnomAD
rs751272765 CA8489069	325	M>V		No	ClinGen ExAC gnomAD
TCGA novel rs1306386331 CA625489029	326	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA8489065 rs765132074	328	C>R		No	ClinGen ExAC gnomAD
CA8489063 rs536439152	329	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA8489064 rs369955695	329	Y>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA399017888 rs1487114302	330	I>M		No	ClinGen TOPMed
CA8489062 rs573703555	331	T>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	333	C>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399017847 rs1247434677	333	C>S		No	ClinGen TOPMed
CA399017832 rs1461832438	334	L>S		No	ClinGen TOPMed
rs1185574638 CA399017810	335	E>G		No	ClinGen TOPMed
rs1598103934 CA399017770	337	F>C		No	ClinGen Ensembl
rs185388825 CA8489060	338	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs185388825 CA8489061	338	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA399017745 rs1383607841	339	K>E		No	ClinGen TOPMed
CA8489058 rs749419856	342	N>D		No	ClinGen ExAC gnomAD
rs1388349837 CA399017681	342	N>S		No	ClinGen gnomAD
CA289430333 rs892177591	344	G>V		No	ClinGen TOPMed
rs1454824456 CA399017627	345	F>L		No	ClinGen gnomAD
CA8489056 rs756651290	346	L>F		No	ClinGen ExAC gnomAD
CA8489055 rs79809527	348	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1421249928 CA399017577	349	K>E		No	ClinGen gnomAD
rs1421249928 CA399017575	349	K>Q		No	ClinGen gnomAD
rs769933589 CA8489036	353	R>K		No	ClinGen ExAC gnomAD
CA399017392 rs1349789085	354	T>I		No	ClinGen TOPMed
rs1349789085 CA399017396	354	T>N		No	ClinGen TOPMed
rs745871937 CA8489035	357	V>I		No	ClinGen ExAC gnomAD
rs781737053 CA8489034	358	F>C		No	ClinGen ExAC gnomAD
rs188945229 CA8489033	359	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747423519 CA8489032	359	R>S		No	ClinGen ExAC gnomAD
CA399017345 rs1290669213	360	K>N		No	ClinGen TOPMed
rs995816638 CA289430011	362	H>Q		No	ClinGen TOPMed
rs758191630 CA8489030	362	H>R		No	ClinGen ExAC gnomAD
rs1354883403 CA399017308	366	L>F		No	ClinGen gnomAD
COSM293104 rs1598103405 CA399017294	368	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	369	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	374	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753239778 CA8489026	374	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs760575975 CA8489024 CA8489025	375	L>F		No	ClinGen ExAC gnomAD
CA399016630 rs1037522835	377	V>F		No	ClinGen TOPMed gnomAD
rs1037522835 CA289428452	377	V>I		No	ClinGen TOPMed gnomAD
rs569963907 CA8489010	378	S>A		No	ClinGen 1000Genomes ExAC gnomAD
rs754565341 CA289428445 COSM3421399	378	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs569963907 CA8489011	378	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs754565341 CA8489009	378	S>W		No	ClinGen ExAC gnomAD
CA8489006 rs756106648	381	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA399016599 rs1214273836	382	Y>*		No	ClinGen TOPMed gnomAD
rs556567297 CA8489005	383	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA8489004 rs745939949	385	L>P		No	ClinGen ExAC gnomAD
rs751261814 CA8489002	388	A>D		No	ClinGen ExAC gnomAD
CA399016559 rs751261814	388	A>V		No	ClinGen ExAC gnomAD
CA399016547 rs1359425221	390	E>D		No	ClinGen gnomAD
CA399016542 rs1297160070	391	V>E		No	ClinGen gnomAD
CA399016531 rs1226375280	393	V>L		No	ClinGen gnomAD
CA8489001 rs765541561	399	F>L		No	ClinGen ExAC gnomAD
rs1304563541 CA399016482	400	R>S		No	ClinGen gnomAD
rs1372052514 CA399016453	405	M>V		No	ClinGen TOPMed
CA289428403 rs1047144544	406	W>C		No	ClinGen gnomAD
rs199600351 CA8488998	407	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA399016427 rs1167570263	408	L>P		No	ClinGen gnomAD
CA289428398 rs957247100	411	Q>E		No	ClinGen TOPMed gnomAD
CA289428395 rs77929397	412	V>G		No	ClinGen TOPMed
CA399016404 rs773858183 CA8488996	412	V>L		No	ClinGen ExAC gnomAD
CA8488995 rs748597148	414	I>M		No	ClinGen ExAC TOPMed gnomAD
CA8488993 rs779117339	415	E>K		No	ClinGen ExAC gnomAD
CA8488992 rs768421985	416	S>P		No	ClinGen ExAC gnomAD
TCGA novel	417	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1438471044 CA399016377	417	K>E		No	ClinGen gnomAD
CA399016371 rs1273960973	417	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA289428377 rs779627678 CA8488991	421	I>L		No	ClinGen ExAC TOPMed gnomAD
CA8488990 rs779627678	421	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA399016342 rs1350384318	422	A>S		No	ClinGen TOPMed gnomAD
rs755629932 CA8488989	422	A>V		No	ClinGen ExAC gnomAD
CA8488988 rs745344623	423	M>R		No	ClinGen ExAC gnomAD
rs150542174 CA8488985	428	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150542174 CA8488984	428	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1281791845 CA399016299	428	A>S		No	ClinGen TOPMed gnomAD
rs150542174 CA8488986	428	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA289428335 rs982757388	429	F>S		No	ClinGen Ensembl
rs367871436 CA289428305	431	H>R		No	ClinGen Ensembl
CA8488982 rs755284760	432	L>P		No	ClinGen ExAC TOPMed gnomAD
CA399016273 rs1176320299	433	K>Q		No	ClinGen gnomAD
CA8488981 rs754126186	434	P>L		No	ClinGen ExAC gnomAD
CA8488957 rs761895113	439	P>L		No	ClinGen ExAC gnomAD
TCGA novel	441	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs267604797 CA289427481	443	S>F		No	ClinGen gnomAD
CA8488956 rs774728283	447	W>G		No	ClinGen ExAC gnomAD
rs763332420 CA8488954	449	E>K		No	ClinGen ExAC gnomAD
rs374155003 CA8488953	450	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1235611713 CA399016143	450	G>S		No	ClinGen TOPMed gnomAD
rs374155003 CA399016139	450	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs866607239 CA289427462	451	A>S		No	ClinGen gnomAD
rs866607239 CA399016138	451	A>T		No	ClinGen gnomAD
CA289427458 rs866112234	451	A>V		No	ClinGen gnomAD
rs1376568429 CA399016125	453	S>G		No	ClinGen gnomAD
CA399016114 rs1425850603	454	Q>R		No	ClinGen TOPMed
rs769474059 CA8488952	456	D>G		No	ClinGen ExAC gnomAD
rs538312192 CA289427443	457	T>A		No	ClinGen 1000Genomes
CA399016090 rs1567780112	458	E>K		No	ClinGen Ensembl
CA399016080 rs1435615949	459	A>S		No	ClinGen gnomAD
rs776259103 CA8488950	460	V>I		No	ClinGen ExAC gnomAD
rs748087505 CA8488926	464	A>T		No	ClinGen ExAC TOPMed gnomAD
CA289427310 rs911119333	464	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1048335945 CA399016006	469	I>L		No	ClinGen TOPMed gnomAD
CA8488924 rs768576449	469	I>M		No	ClinGen ExAC TOPMed gnomAD
rs375793542 CA8488925	469	I>T		No	ClinGen ESP ExAC TOPMed
rs1048335945 CA289427307	469	I>V		No	ClinGen TOPMed gnomAD
rs1340054753 CA399015962	476	L>Q		No	ClinGen TOPMed
TCGA novel	477	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1245779772 CA399015942	479	K>E		No	ClinGen TOPMed
rs371673397 CA8488919	482	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs371673397 CA399015922	482	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1369017913 CA399015908	483	W>C		No	ClinGen gnomAD
CA399015901 rs1207892874	484	A>V		No	ClinGen TOPMed
rs773706341 CA8488918 COSM977532	486	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773706341 CA289427275	486	R>G		No	ClinGen ExAC TOPMed gnomAD
rs765665411 CA8488916	486	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM184320 CA8488917 rs765665411	486	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA399015888 rs1197408528	487	S>N		No	ClinGen gnomAD
rs759849700 CA8488915	489	G>A		No	ClinGen ExAC TOPMed gnomAD
CA399015876 rs1598098928	489	G>S		No	ClinGen Ensembl
rs754180295 CA8488914	491	K>R		No	ClinGen ExAC gnomAD
rs765995552 CA8488913	492	K>Q		No	ClinGen ExAC gnomAD
CA399015844 rs1243490265	494	R>G		No	ClinGen Ensembl
rs1187779732 CA399015834	495	A>G		No	ClinGen TOPMed
rs367840485 CA8488912	496	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA289424095 rs1038913456	500	L>S		No	ClinGen Ensembl
rs541168861 CA8488887	502	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572461469 CA8488885 COSM3387787	504	R>*	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs572461469 CA289424090	504	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA8488884 rs141710819	504	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs772231800 CA8488883	506	F>L		No	ClinGen ExAC gnomAD
CA8488882 rs748276640	508	V>A		No	ClinGen ExAC gnomAD
TCGA novel	509	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	512	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	512	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8488881 rs778932634	515	I>N		No	ClinGen ExAC gnomAD
CA399015368 rs1322484075	516	Q>H		No	ClinGen gnomAD
rs984989394 CA289424067	517	F>S		No	ClinGen TOPMed
rs555519103 CA8488880	520	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs539111208 CA399015343	520	E>K		No	ClinGen TOPMed gnomAD
rs539111208 CA289424063	520	E>Q		No	ClinGen TOPMed gnomAD
TCGA novel	521	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399015287 rs1304013408	525	N>S		No	ClinGen TOPMed
CA8488866 rs759347495	526	M>L		No	ClinGen ExAC gnomAD
CA399015278 rs1226726149	526	M>T		No	ClinGen gnomAD
CA8488865 rs776386716	527	A>V		No	ClinGen ExAC TOPMed gnomAD
rs762017108 CA8488863	529	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1330024986 CA399015234	530	R>G		No	ClinGen gnomAD
CA8488862 rs774500050	530	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1431066932 CA399015225	530	R>S		No	ClinGen gnomAD
TCGA novel	531	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8488860 rs749289159	533	Y>H		No	ClinGen ExAC gnomAD
rs780634050 CA8488859	535	R>T		No	ClinGen ExAC TOPMed gnomAD
CA399015162 rs1567774576	536	A>T		No	ClinGen Ensembl
CA8488858 rs770182274	536	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8488857 rs746276896	538	R>G		No	ClinGen ExAC
CA8488854 rs757031414	543	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8488853 rs147417068	544	D>G		No	ClinGen ESP ExAC
TCGA novel	544	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399014824 rs1286820711	546	D>E		No	ClinGen gnomAD
rs1299115631 CA399014827	546	D>G		No	ClinGen TOPMed
CA399014823 rs1180319359	547	L>F		No	ClinGen gnomAD
rs1180319359 CA399014821	547	L>V		No	ClinGen gnomAD
CA399014812 rs1399180852	548	W>*		No	ClinGen TOPMed
CA399014797 rs1408574494	550	D>N		No	ClinGen TOPMed
rs747335374 CA8488828	552	M>T		No	ClinGen ExAC gnomAD
rs771422115 CA8488829	552	M>V		No	ClinGen ExAC gnomAD
rs777500047 CA8488827	553	K>E		No	ClinGen ExAC TOPMed gnomAD
rs752289742 CA8488825	558	H>Q		No	ClinGen ExAC gnomAD
rs1270588091 CA399014736	558	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA399014728 rs1329267763	559	P>L		No	ClinGen gnomAD
TCGA novel	559	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778282945 CA8488824	561	G>R		No	ClinGen ExAC TOPMed gnomAD
rs200802612 CA289420646	562	R>K		No	ClinGen 1000Genomes
CA289420639 rs943253628	563	P>T		No	ClinGen TOPMed gnomAD
rs753780409 CA8488821	566	C>W		No	ClinGen ExAC gnomAD
CA8488822 rs201762567	566	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1322500996 CA399014678	567	G>V		No	ClinGen gnomAD
rs924815751 CA289420614	568	Q>H		No	ClinGen TOPMed
rs766265317 CA8488820	569	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8488819 rs199655991	572	R>*		No	ClinGen 1000Genomes ExAC gnomAD
CA399014644 rs909046283	572	R>P		No	ClinGen TOPMed gnomAD
CA289420600 rs909046283	572	R>Q		No	ClinGen TOPMed gnomAD
rs750165197 CA399014639	573	A>G		No	ClinGen ExAC TOPMed gnomAD
rs750165197 COSM977531 CA8488818	573	A>V	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1250237694 CA399014577	581	S>L		No	ClinGen gnomAD
TCGA novel	582	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763083700 CA8488816	583	E>G		No	ClinGen ExAC gnomAD
rs1464876415 CA399014559	584	A>G		No	ClinGen TOPMed gnomAD
rs1464876415 CA399014560	584	A>V		No	ClinGen TOPMed gnomAD
rs1598089523 CA399014553	585	F>S		No	ClinGen Ensembl
TCGA novel	586	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8488815 rs536356581	587	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA399014519 rs1312995319	590	A>G		No	ClinGen TOPMed gnomAD
CA8488813 rs759619796	590	A>T		No	ClinGen ExAC TOPMed
CA399014518 rs1312995319	590	A>V		No	ClinGen TOPMed gnomAD
CA399014512 rs1380334913	591	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8488811 rs142869504	591	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs771513885 CA8488810	592	H>N		No	ClinGen ExAC gnomAD
rs567410999 CA8488809	592	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA399014490 rs1168478878	594	T>I		No	ClinGen TOPMed
CA289420505 rs1022754946	595	G>S		No	ClinGen TOPMed
rs771824075 CA8488807	598	L>G		No	ClinGen ExAC gnomAD

No associated diseases with Q9NYH9

7 regional properties for Q9NYH9

Type	Name	Position	InterPro Accession
repeat	HAT (Half-A-TPR) repeat	87 - 119	IPR003107-1
repeat	HAT (Half-A-TPR) repeat	121 - 153	IPR003107-2
repeat	HAT (Half-A-TPR) repeat	156 - 188	IPR003107-3
repeat	HAT (Half-A-TPR) repeat	304 - 335	IPR003107-4
repeat	HAT (Half-A-TPR) repeat	452 - 486	IPR003107-5
repeat	HAT (Half-A-TPR) repeat	488 - 520	IPR003107-6
repeat	HAT (Half-A-TPR) repeat	524 - 557	IPR003107-7

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
Pwp2p-containing subcomplex of 90S preribosome	A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.
small-subunit processome	A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name	Definition
snoRNA binding	Binding to a small nucleolar RNA.

1 GO annotations of biological process

Name	Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02354	UTP6	U3 small nucleolar RNA-associated protein 6	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8VCY6	Utp6	U3 small nucleolar RNA-associated protein 6 homolog	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAEIIQERIE	DRLPELEQLE	RIGLFSHAEI	KAIIKKASDL	EYKIQRRTLF	KEDFINYVQY
70	80	90	100	110	120
EINLLELIQR	RRTRIGYSFK	KDEIENSIVH	RVQGVFQRAS	AKWKDDVQLW	LSYVAFCKKW
130	140	150	160	170	180
ATKTRLSKVF	SAMLAIHSNK	PALWIMAAKW	EMEDRLSSES	ARQLFLRALR	FHPECPKLYK
190	200	210	220	230	240
EYFRMELMHA	EKLRKEKEEF	EKASMDVENP	DYSEEILKGE	LAWIIYKNSV	SIIKGAEFHV
250	260	270	280	290	300
SLLSIAQLFD	FAKDLQKEIY	DDLQALHTDD	PLTWDYVARR	ELEIESQTEE	QPTTKQAKAV
310	320	330	340	350	360
EVGRKEERCC	AVYEEAVKTL	PTEAMWKCYI	TFCLERFTKK	SNSGFLRGKR	LERTMTVFRK
370	380	390	400	410	420
AHELKLLSEC	QYKQLSVSLL	CYNFLREALE	VAVAGTELFR	DSGTMWQLKL	QVLIESKSPD
430	440	450	460	470	480
IAMLFEEAFV	HLKPQVCLPL	WISWAEWSEG	AKSQEDTEAV	FKKALLAVIG	ADSVTLKNKY
490	500	510	520	530	540
LDWAYRSGGY	KKARAVFKSL	QESRPFSVDF	FRKMIQFEKE	QESCNMANIR	EYYERALREF
550	560	570	580	590
GSADSDLWMD	YMKEELNHPL	GRPENCGQIY	WRAMKMLQGE	SAEAFVAKHA	MHQTGHL