Q02354
PR
Gene name |
UTP6 (YDR449C, D9461.34) |
Protein name |
U3 small nucleolar RNA-associated protein 6 |
Names |
U3 snoRNA-associated protein 6, U three protein 6 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR449C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
22 structures for Q02354
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5WLC | EM | 380 A | LP | 1-326 | PDB |
| 6KE6 | EM | 340 A | B6 | 1-440 | PDB |
| 6LQP | EM | 320 A | B6 | 1-440 | PDB |
| 6LQQ | EM | 410 A | B6 | 1-440 | PDB |
| 6LQR | EM | 860 A | B6 | 1-440 | PDB |
| 6LQS | EM | 380 A | B6 | 1-440 | PDB |
| 6LQT | EM | 490 A | B6 | 1-440 | PDB |
| 6LQU | EM | 370 A | B6 | 1-440 | PDB |
| 6LQV | EM | 480 A | B6 | 1-440 | PDB |
| 6ND4 | EM | 430 A | P | 1-326 | PDB |
| 6ZQA | EM | 440 A | UF | 1-440 | PDB |
| 6ZQB | EM | 390 A | UF | 1-440 | PDB |
| 6ZQC | EM | 380 A | UF | 1-440 | PDB |
| 6ZQD | EM | 380 A | UF | 1-440 | PDB |
| 7AJT | EM | 460 A | UF | 1-440 | PDB |
| 7AJU | EM | 380 A | UF | 1-440 | PDB |
| 7D4I | EM | 400 A | B6 | 1-440 | PDB |
| 7D5S | EM | 460 A | B6 | 1-440 | PDB |
| 7D5T | EM | 600 A | B6 | 1-440 | PDB |
| 7D63 | EM | 1230 A | B6 | 1-440 | PDB |
| 7SUK | EM | 399 A | LP | 2-326 | PDB |
| AF-Q02354-F1 | Predicted | AlphaFoldDB |
6 variants for Q02354
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1358073 | 274 | F>L | No | SGRP | |
| s04-1357796 | 367 | I>V | No | SGRP | |
| s04-1357737 | 386 | L>F | No | SGRP | |
| s04-1357694 | 401 | A>T | No | SGRP | |
| s04-1357608 | 429 | R>S | No | SGRP | |
| s04-1357586 | 437 | I>F | No | SGRP |
No associated diseases with Q02354
3 regional properties for Q02354
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 87 - 119 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 124 - 156 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 159 - 191 | IPR003107-3 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| 90S preribosome | A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| Pwp2p-containing subcomplex of 90S preribosome | A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| snoRNA binding | Binding to a small nucleolar RNA. |
| U3 snoRNA binding | Binding to a U3 small nucleolar RNA. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKTRYYLEQ | CIPEMDDLVE | KGLFTKNEVS | LIMKKRTDFE | HRLNSRGSSI | NDYIKYINYE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SNVNKLRAKR | CKRILQVKKT | NSLSDWSIQQ | RIGFIYQRGT | NKFPQDLKFW | AMYLNYMKAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GNQTSYKKIH | NIYNQLLKLH | PTNVDIWISC | AKYEYEVHAN | FKSCRNIFQN | GLRFNPDVPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LWYEYVKFEL | NFITKLINRR | KVMGLINERE | QELDMQNEQK | NNQAPDEEKS | HLQVPSTGDS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MKDKLNELPE | ADISVLGNAE | TNPALRGDIA | LTIFDVCMKT | LGKHYINKHK | GYYAISDSKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NIELNKETLN | YLFSESLRYI | KLFDEFLDLE | RDYLINHVLQ | FWKNDMYDLS | LRKDLPELYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTVMIDITLN | IRYMPVEKLD | IDQLQLSVKK | YFAYISKLDS | ASVKSLKNEY | RSYLQDNYLK |
| 430 | |||||
| KMNAEDDPRY | KILDLIISKL |