Q8VCY6
Gene name |
Utp6 (Mhat) |
Protein name |
U3 small nucleolar RNA-associated protein 6 homolog |
Names |
Multiple hat domains protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:216987 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VCY6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VCY6-F1 | Predicted | AlphaFoldDB |
38 variants for Q8VCY6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389172216 | 92 | V>E | No | EVA | |
| rs3389186077 | 125 | H>Y | No | EVA | |
| rs3389148750 | 143 | L>V | No | EVA | |
| rs3389160200 | 144 | W>C | No | EVA | |
| rs3389160219 | 148 | A>P | No | EVA | |
| rs218451987 | 179 | Y>F | No | EVA | |
| rs3389186798 | 185 | M>T | No | EVA | |
| rs3389121248 | 292 | Q>K | No | EVA | |
| rs28247620 | 302 | E>G | No | EVA | |
| rs248621592 | 305 | R>Q | No | EVA | |
| rs3389172151 | 327 | W>* | No | EVA | |
| rs3389185037 | 328 | K>R* | No | EVA | |
| rs3389154916 | 330 | Y>F | No | EVA | |
| rs3389172139 | 331 | I>V | No | EVA | |
| rs3402488225 | 338 | F>L | No | EVA | |
| rs3389194329 | 351 | R>S | No | EVA | |
| rs3389182051 | 367 | L>P | No | EVA | |
| rs3389121193 | 375 | Q>L | No | EVA | |
| rs3389194392 | 382 | R>P | No | EVA | |
| rs3389179447 | 391 | Q>* | No | EVA | |
| rs3389121215 | 397 | T>N | No | EVA | |
| rs3389154976 | 398 | E>* | No | EVA | |
| rs3389181985 | 399 | L>V | No | EVA | |
| rs3389194303 | 418 | K>N | No | EVA | |
| rs264975793 | 420 | P>L | No | EVA | |
| rs254459310 | 452 | A>T | No | EVA | |
| rs3389185015 | 465 | A>V | No | EVA | |
| rs3389198985 | 481 | Y>N | No | EVA | |
| rs3389160278 | 488 | S>I | No | EVA | |
| rs3389188858 | 499 | K>N | No | EVA | |
| rs3389154972 | 503 | E>G | No | EVA | |
| rs3389186737 | 511 | F>L | No | EVA | |
| rs3412852253 | 543 | T>I | No | EVA | |
| rs257451597 | 543 | T>S | No | EVA | |
| rs3389186753 | 551 | D>E | No | EVA | |
| rs3389186811 | 576 | K>E | No | EVA | |
| rs3402648920 | 596 | G>C | No | EVA | |
| rs3401266047 | 598 | H>W | No | EVA |
No associated diseases with Q8VCY6
6 regional properties for Q8VCY6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 87 - 119 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 121 - 153 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 156 - 188 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 305 - 336 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 489 - 521 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 525 - 558 | IPR003107-6 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| Pwp2p-containing subcomplex of 90S preribosome | A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| snoRNA binding | Binding to a small nucleolar RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEIIQERIE | DRIPELEQLE | RIGLFSHAEI | KAIIKKASDL | EYKIHRRTLL | KEDFINYVQY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EINLLELIQR | RRARIKYSFK | KDEIEYSMVH | RVQGVFGRAS | AKWKDDVQLW | LSYIVFCKKW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTKTHLSKIF | SAMLAIHSNK | PALWIMAAKW | EMEDRLSSES | ARQLFLRALR | FHPECPKLYQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EYFRMELMHA | EKLRKEKQEF | EKAAMDMGDF | DHPEEILKGE | LARIIYKNSI | SKIKGAEFHV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLLAIAQLFD | FAKDLQKEIY | DDLQALHTDD | PLTWDYVARR | ELEIESQPGE | EQPVSKQAKA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEMGRREERC | CAVYEEAVKA | LPTEAMWKCY | ITFCLERFSK | KTSSVPLRGQ | RLERTMLAFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KAHELKLLSE | VQYKQWIDLL | LRQDLFKEAL | QVAEAGTELF | KDSVTMWQTK | LQVLIDSKSP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DVEMRFEEAF | AHLKPQVCLP | LWISWAEWSE | SAKSQEDTEA | IFKKAIIAVT | GASSVTLKEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YLDWAYRSGG | YKKARAVFKS | LQESRPFSVE | FFRKMMQFEK | EQEPCKMVNL | REYYERALRE |
| 550 | 560 | 570 | 580 | 590 | |
| FGTSDSDLWM | DYIKEELNHP | FGKPENCGQI | YWRAMKMLQG | QSAELFVAKH | AMHQAGH |